DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tud and Tdrd6

DIOPT Version :9

Sequence 1:NP_476773.1 Gene:tud / 37417 FlyBaseID:FBgn0003891 Length:2515 Species:Drosophila melanogaster
Sequence 2:NP_001154838.1 Gene:Tdrd6 / 210510 MGIID:2679727 Length:2135 Species:Mus musculus


Alignment Length:2377 Identity:465/2377 - (19%)
Similarity:803/2377 - (33%) Gaps:825/2377 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   406 LTVGLTYDVVISYVENGPYLFWVHLKSSD---HDLSTMMGQIERTKL------------KALAQA 455
            |.:|:|..||::.|.: |:.....|:|..   |.||..|.|:.|..:            :...::
Mouse   245 LQLGVTEPVVVTQVCH-PHRIHCQLRSLSQEIHRLSESMAQVYRAPVGTDDEDSGSATWEEREES 308

  Fly   456 PEL-GTACVARFSEDGHLYRAMVCAVY-AQR-YRVVYVDYGNSELLSASDLFQIPPELLEIKPFA 517
            |:. |:.| |....||..|||::...: .|| .:|::||||..||:|.|.|..:.||...:....
Mouse   309 PDKPGSPC-ASCGLDGQWYRALLLETFRPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVT 372

  Fly   518 FRFALAGTKEI------EPIDDSMKRIFKKSAI------YRNFE----LTVQAPESVG-----SM 561
            :..||.|..:.      ..:.| :|.:....|:      |.:||    :|:...:.:.     .:
Mouse   373 YPCALYGLWDCGRGWSRSQVGD-LKALILGQAVNAKIEFYCSFEHMYYVTLYGEDGINLNSAFGV 436

  Fly   562 QTC-----HLNQNGTNMLEL--LRQLKNSRQSYKKAEQLEND-----------------DAVEIR 602
            |:|     .|...|....|.  ..:::.:.||...||::|.:                 || ::.
Mouse   437 QSCCLADWFLQSQGIEEEEEEDEDEVEAAFQSQSPAEEMEAEVSLPSLRSIRLKMNTFYDA-QVE 500

  Fly   603 FIDSPSNFYVQKVANIGKFEQLMDEMFSYYNANQRV--------PDQLILGAPCIVKCDQE-WYR 658
            |:.|||.|:::...:...|.:|...|.|:|::..::        ||.|     |.||..:. :||
Mouse   501 FVKSPSEFWIRLRKHKNTFSKLTKRMCSFYSSASKLDGVILRPEPDDL-----CCVKWKENGYYR 560

  Fly   659 AEILRVDD-SVIVRHVDFGYEQNVKRHLIGHIAEKHLEMPRQAIKCCLKGFENSELSEDKITDQF 722
            |.:.|:|. ||.|..||.|..:||....:..:..:..::|..|:||.|                 
Mouse   561 ATVTRLDSKSVDVFLVDRGNSENVDWCDVRMLLPQFRQLPILALKCTL----------------- 608

  Fly   723 EMLAEESNIRRRTFSVRIFRIEPDGLNVVNLLAKNLNVMKKLYKLSMPFEQYLSLEKGQFNANNT 787
                                                   ..::.|...:.|         .|.:.
Mouse   609 ---------------------------------------ADIWPLGKTWSQ---------EATSF 625

  Fly   788 RAESVISSELNKSHILNSTSIGETENRLQEQEKEQQQKKVDVRQQQLAVEIPQAVKSVSGSKNST 852
            ..::|:..|| ..|:|                        |.:..|..:||              
Mouse   626 FKKTVLHKEL-VVHVL------------------------DKQDHQYVIEI-------------- 651

  Fly   853 DWDKRSSTSAGSKDSKRQQQQQIQRIDRHLDFSCETQSTGSYSSGMSSPRKGNRQQNGRTPIQSP 917
                        .|..|..::.|.::              ...:|.:..::...::|.|....||
Mouse   652 ------------LDESRMGEENISKV--------------IAQAGFAKFQEFETKENIRLSAHSP 690

  Fly   918 RHNEKQEAKKNARFSNSESPRRSRDGQQGNQRSQNAPQGYAQKPQRQKSTLDGNISSKRSSGVGS 982
            .|       .:..|....|...|....:|:||:           ::...||  ::|...:..|..
Mouse   691 GH-------VSGHFMAEPSKITSAKKAEGDQRA-----------KKDNKTL--SVSEALADTVSL 735

  Fly   983 DIASSSSESVAAAKPEKYVSLD----KP--YALQEMKTPSKEAASLSWWLSPFQFYIVPKSVSAK 1041
            ...|::.::.........:.|:    ||  ....|::..|.....:|...:|..|:......:..
Mouse   736 SNLSTAQDTEKVTSDPSLLMLNFLKTKPDCCGKGELEVGSTVEVKVSHIENPGSFWCQLMRNAQG 800

  Fly  1042 YDNIMRDMREFYRQKQHQPLQLKVGSTVV--VRQRKDNAILRATVTACNHMMRKYRVFCVDTGSL 1104
            :..:|.|:.::.:..:..|.:   |.|.|  .::.......||.::.. |.:...||..||.|..
Mouse   801 FRTLMCDIEDYCKSSEPSPYE---GDTRVCLAKRTASGRWSRALISGA-HSLEHVRVVFVDYGDR 861

  Fly  1105 ITVTSEDIWQLEQRFADPPCMAHRCSFHSVVTNYDPLYIVDRMETFVPVNAKVDCEFVSKEKSNQ 1169
            ..|:::||..:...|......|.|||.::::.               |:.   :..||..||:.|
Mouse   862 DVVSTKDILSVSDVFFQVRAQAFRCSLYNLIQ---------------PMG---ENPFVWDEKAVQ 908

  Fly  1170 GSNTSSTCSYTVNIFVNGASLRDMLVKAEFLTEVAPEIRVNLLAGQQIRGKFTSIRDMTSFKVQF 1234
            ..:.          |::.|...::.:|.          .|..||.:.                :.
Mouse   909 AFSG----------FIDSARQNNLELKC----------TVFALASRH----------------EE 937

  Fly  1235 DYGNNVNFLCTYDDAKFVKSNPNLARRFKEFYEGKSFALNVKNVCENNIVHLRPVMPLFMEDRRS 1299
            ::.|.|:.|..:..|........|||..|                     |.:|:.| .::....
Mouse   938 EWFNVVDLLTPFQSACRFLVEKRLARPVK---------------------HQKPLEP-SVQLHSY 980

  Fly  1300 FICPYPVVLSSFQAL-VVYTAKPYRVYVQPQAIVPSMQTLLDNMYEHYKA----KGDSLKKFDVG 1359
            :...:.:.:.|.:.: |.:...|:..|.|.......::.|..|:.:..||    |..:|..   |
Mouse   981 YYSTHDLKIGSEELVYVTHADDPWTFYCQLARNTNVLEQLSYNIMQLSKALLNLKASTLAP---G 1042

  Fly  1360 QICAVRSSDGNWYRARISGKDSNAACFEVFYIDYGNTEEIKRDDIKALDAKFYEHASGFAVEINL 1424
            .:|..|.:||||||..|..|:.:    :||::|:|||.                    .||:..|
Mouse  1043 TLCLARYTDGNWYRGIIIEKEPS----KVFFVDFGNTY--------------------IAVDHLL 1083

  Fly  1425 PIGRPSNDT------KLKARISEILEEKVVTIKSIEVRRSHLIADVILENNQSVID-LLKAEKLV 1482
            ||.|.::|.      .||..:|:|              ..|:..:|.....::|:| .|||  ||
Mouse  1084 PIPRDAHDVLLLPMQALKCSLSDI--------------PHHIPEEVTAWFQETVLDKSLKA--LV 1132

  Fly  1483 PGKDLDYMRKQMEKGKSRTYEYIETVDLTLDEEEDKGRKETVSKSGSANASPKKKQHND------ 1541
            ..||.|        |:.....|.::|.:.....|..|      ..|..|.:.:|::.|:      
Mouse  1133 VAKDPD--------GRLIIELYDDSVQINASINEKLG------LLGYKNRTRRKEKENEIILYET 1183

  Fly  1542 KDREPKKSKPAEPARTVAPQPVALKTPSPVPAEPAPVPKPATPVPEVVEV------PEINPTVRE 1600
            |..|.||.                   |..|:....:.||.......||:      |::.|..:|
Mouse  1184 KALEDKKE-------------------SVKPSLADYLSKPGESKAHSVEIMGESCKPKMGPACKE 1229

  Fly  1601 -----AAAESKQAPAQEDPYKDLDCVVLSHCDNPAQFYVHPIDQLSKLNQLHENLQIVSPSLPQL 1660
                 .:|::...|..:|...:         .|...|   |:.:..|     |::...||     
Mouse  1230 LRYLQGSAKANLVPPYQDSVGN---------KNDGGF---PLTREKK-----EDIFASSP----- 1272

  Fly  1661 MNVVNGADCVSMYSVDKCWYRAKIIDAELMVLLFIDYGNTDCVSDATDIKESMWSHIEPFCLPCA 1725
               ::|..                                                     |..|
Mouse  1273 ---MSGTK-----------------------------------------------------LDSA 1281

  Fly  1726 LPIRPKGTADWVDAANGIFNESYSKVPRLEYLTQGDHYTTSYVNMYIDGEDVAKKLIADGFARPL 1790
            ||.|..|.....|     ....:.:.|                          :|.||.||.   
Mouse  1282 LPERRMGEPSGRD-----LPPKFCEFP--------------------------QKTIAPGFK--- 1312

  Fly  1791 EYLASGCSCYISHVNGICDFFIQLERDSKALELIELYLRKKDT-LKPL----EGFEKGLIVAALF 1850
                  .|.|:||:|.:.||:|||..|.  .|:..|..|..|. .:|.    ..::.|.::.|:|
Mouse  1313 ------TSVYVSHINDLSDFYIQLIEDE--AEINNLSERLNDVRTRPQYHTGPQWQSGDVICAVF 1369

  Fly  1851 EDDELWYRAQLQKELPDSRYEVLFIDYGNTST--TSKCLMLSEEIASLPSLSKKCSL-------- 1905
            .:|.|||||.:.::.|:....|.||||||.|.  |::...|....|.||:|...|||        
Mouse  1370 PEDNLWYRALVMEQQPNGLLSVQFIDYGNMSVVHTNRTGRLGPVDAVLPALCLHCSLWGLSVPVC 1434

  Fly  1906 -QLPDAYISWSPEAE--AKFAELTGEGELV-------------------------FTTQLL---- 1938
             ::...:...:.||:  .:|.:..|..|::                         .|||.:    
Mouse  1435 KEMVSYFSQRTDEAQIRCEFVKFQGTWEVILADEHGVIAEDMISRFPCNGNSQAGLTTQTMKGDC 1499

  Fly  1939 -----KPGQDHVTIDLLLDGENIIDRLLPLCQRKEPKEASKESLAVTTKAIITHVENTSRIYLQF 1998
                 ||..|   ..:||:..|             ||       |...||..|.::.....:.||
Mouse  1500 LKIANKPNAD---TSVLLNWYN-------------PK-------AKLIKAYATVIDGPEYFWCQF 1541

  Fly  1999 SEKDSLMDIICE-KLNGSKLQPK---TEKAAVDDMCVVQFADDLEFYRSRILEVLEDDQYKVILI 2059
            ::.:.|..:..| :..|.:|..:   |:...:.|.|:|::.:|..:||:.|..:.:.:...|.|:
Mouse  1542 ADSEKLQYLETEVQSAGKQLSDRRSCTQCPQIGDPCIVRYREDGHYYRALITNICDGELASVRLV 1606

  Fly  2060 DYGNT-TVVD--KLYELPQEFTLIKPVA------------EICSMEPSAIFEKNKALTLTTFDAL 2109
            |:||. ..||  :|:.:|.|..|:...|            .:|..|.:..|          :|.:
Mouse  1607 DFGNAEDCVDAKELWSIPSELLLVPMQAFPCCLAGFSVSGGVCPQEGNDYF----------YDIV 1661

  Fly  2110 LDSCKGVVAVEFVNKSASPP--VVRLTTKDKRSLKIYEHLQKLVQAELK----LIQKRNENSECI 2168
            .:....:..:|......:.|  :|.|.:|.:   .|.|.::|..:..:.    ..:||....:..
Mouse  1662 TEDVLDITILEIKRDVCNIPLAIVELRSKGE---NINEKMKKYAKTGVPKNDLSSEKRGPERKGS 1723

  Fly  2169 ISYGNSP--------------KSFYVQMKHNS----ADLDLIVKTLQSLKKEKLKKLIDPTTNSN 2215
            ::   ||              |:||.:.:.:.    .:.||.::|       |..|..:.:|.| 
Mouse  1724 LA---SPDLGLKKPSHKIAQDKTFYGEARASELSERLEKDLNIET-------KTSKFYERSTRS- 1777

  Fly  2216 GVCYSQEDACYYRCSIKSV--------LDPSQGFEVFLLDYGNTLVVPEVWQLPQEIEPIPSLAL 2272
             :..:.|::|..:...:.:        :|.::....:|:...|.::...  ..|:|:..:.||  
Mouse  1778 -IFNAFENSCKGKMGSERLEGSMDYHFVDRAKFDNNYLITGFNPILAHA--SEPKELLELSSL-- 1837

  Fly  2273 HCQLSKIPMDVSDEKLEEAFAALLEQHFGELYEITTQPNEDETKPLIAELRINYKDFVQELVSTV 2337
                 ::|:...::...:.|..|      |..|:...|..:|.|              :||    
Mouse  1838 -----EVPLSADNDDECKEFLEL------ESIELQHSPVGEEEK--------------EEL---- 1873

  Fly  2338 TGVQKPLEAELHNCVVVQFDGPM-SFYVQMESDVPALEQMTDKL----LDAEQDLPAFS-----D 2392
             |:..|:......|   |....: ||.:|:..|..|.:|:..||    |..|..:...|     |
Mouse  1874 -GLGSPMAPLSPGC---QAGATLESFMMQLPLDCEAEKQLELKLPTPQLSLEDSISPLSAAVSQD 1934

  Fly  2393 LKEGALCVAQFPEDEVFYRAQIRK---------------VLDDGKCEVHFIDFGNNAVTQQFRQL 2442
            ::|     :::.|||       ||               :|..||        |.|:.....|.|
Mouse  1935 IQE-----SRYSEDE-------RKAGYMGSSDDDHSRSPLLQHGK--------GGNSPAHGGRNL 1979

  Fly  2443 PEE------------LAKP------ARYSRHCELDASTISKCDAALLQSFIDTRFSETFQV---- 2485
            .||            |..|      ||..|.|.      |...||.|||   |...:.|.|    
Mouse  1980 SEEEFPQFESRDSAALLAPLFSEEEAREGRKCG------SMVPAAQLQS---TYTLKGFSVGSKC 2035

  Fly  2486 -------------EILATKGTGTHVVRLFYQSKNISE 2509
                         |||.....||.|:.|   |..:.|
Mouse  2036 VVWSSLRNTWSKCEILELAEEGTRVLNL---SNGVEE 2069

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tudNP_476773.1 DUF1421 198..>397 CDD:284607
TUDOR 406..524 CDD:278965 40/135 (30%)
TUDOR 454..510 CDD:197660 22/58 (38%)
TUDOR 591..707 CDD:278965 38/142 (27%)
TUDOR 644..693 CDD:197660 16/50 (32%)
TUDOR 1012..1132 CDD:278965 26/121 (21%)
TUDOR 1062..1119 CDD:197660 14/58 (24%)
TUDOR 1309..1425 CDD:278965 30/120 (25%)
TUDOR 1354..1411 CDD:197660 17/56 (30%)
TUDOR 1614..1727 CDD:278965 10/112 (9%)
TUDOR 1666..1711 CDD:119391 1/44 (2%)
TUDOR 1791..1906 CDD:278965 43/130 (33%)
TUDOR 1843..1886 CDD:119391 19/44 (43%)
TUDOR 1975..2089 CDD:278965 31/132 (23%)
TUDOR 2028..2069 CDD:119391 14/43 (33%)
TUDOR 2159..2277 CDD:278965 23/143 (16%)
TUDOR 2210..2264 CDD:197660 8/61 (13%)
TUDOR 2345..2458 CDD:278965 35/155 (23%)
TUDOR 2396..2437 CDD:119391 10/55 (18%)
Tdrd6NP_001154838.1 TUDOR 10..133 CDD:278965
TUDOR 245..379 CDD:278965 40/135 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 287..315 3/27 (11%)
TUDOR 313..359 CDD:119391 19/46 (41%)
TUDOR 489..610 CDD:278965 36/182 (20%)
TUDOR 547..591 CDD:119391 17/48 (35%)
TUDOR 773..890 CDD:278965 26/120 (22%)
TUDOR 826..869 CDD:119391 10/43 (23%)
TUDOR 987..1106 CDD:278965 37/145 (26%)
TUDOR 1042..1084 CDD:119391 19/65 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1271..1296 10/90 (11%)
TUDOR 1309..1428 CDD:278965 45/129 (35%)
TUDOR 1362..1406 CDD:119391 19/43 (44%)
TUDOR 1519..1641 CDD:278965 32/128 (25%)
TUDOR 1574..1621 CDD:119391 14/46 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1699..1733 5/36 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1860..1885 7/43 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1930..1987 16/76 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167839574
Domainoid 1 1.000 69 1.000 Domainoid score I9631
eggNOG 1 0.900 - - E1_COG1525
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002918
OrthoInspector 1 1.000 - - otm43805
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR22948
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4796
SonicParanoid 1 1.000 - - X4998
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
109.870

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