DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tud and TDRD5

DIOPT Version :9

Sequence 1:	NP_476773.1	Gene:	tud / 37417	FlyBaseID:	FBgn0003891	Length:	2515	Species:	Drosophila melanogaster
Sequence 2:	NP_001186014.1	Gene:	TDRD5 / 163589	HGNCID:	20614	Length:	1035	Species:	Homo sapiens

Alignment Length:	1043	Identity:	208/1043 - (19%)
Similarity:	354/1043 - (33%)	Gaps:	288/1043 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1252 VKSNPNLARRFKEFYEGKSFALNVKNVCENNIVHLRPVMPLFME-DRRSFICPYPVVLSSFQALV 1315
            :.|.|...||..  |.|:                :.|::|..:: :.:..:...||:||.|:...
Human   111 IYSGPRSHRRVP--YRGR----------------VAPILPAVVKSELKDLLALSPVLLSDFEKAF 157

  Fly  1316 VYTAKPYRVYVQPQAIVPSMQTLLDNMYEHYKAKGD--SLKKFDVGQICAVRSSDGNWYRARISG 1378
               ||.:....|      .||....:|:|...|..|  |:::...|.:..::.|       ....
Human   158 ---AKRFGRSFQ------YMQYGFLSMFEVLNAASDVISVEQTRAGSLLMLKKS-------VTEE 206

  Fly  1379 KDSNAACFEVFYIDYGNTEEIKRDDIKALDAKFYEHASGFAVEINLPIGRP--SNDTKLKARISE 1441
            |.......::|      |:..:        .|...:::||      |:.:|  |..|.......:
Human   207 KPRGCPAGKIF------TQPFR--------MKQGSYSTGF------PVAKPCFSQPTSNMEPPKQ 251

  Fly  1442 ILE-EKVVTIKSIEVRR-SHLIADVILENN-QSVI-----------DLLKAEKLVPGK------- 1485
            |:. ||...:..:|..| :|......|||. :|||           :|....|.|..|
Human   252 IMSMEKTSKLNVVETSRLNHTEKLNQLENTFKSVIAQIGPGGTISSELKHKIKFVVSKFPEGLFI 316

  Fly  1486 -----DLDYMRKQMEKGKSRTY----EYIETVDLTLDEEEDKGRKETVSKSGSANASPKKKQHND 1541
                 :.:.:.|:....|...:    |.:..:...|..|..||.::.:  ...|:..|.....:|
Human   317 SKLLGEYEVIFKEQLSPKKLGFLNVTELVGALSDILHVEFRKGHQDLL--VFDADKKPLPPVQSD 379

  Fly  1542 KDREPK---KSKPAEPARTVAPQPVALKTPSPVPAEPAP--VPKPATPVPEVVEVPEINPTVREA 1601
            |..|.|   .|.|.....|.|.:......||....||..  ..||...|..:....|.|.:....
Human   380 KKIEAKACVSSPPRNSLSTAAVKETVWNCPSKKQKEPQQKICKKPNLVVKPLQLQVETNKSELNL 444

  Fly  1602 AAESKQAPAQEDPYKDLDC------------VVLSHCDNPAQFYVHPI---------DQLSKLNQ 1645
            |..:...|....|.|.| |            |.:.:..:|:|||:...         |.:.::.:
Human   445 AMANHDIPPDAVPNKKL-CRLPPLDTSSLIGVFVEYIISPSQFYIRIYSRDSSELLEDMMIEMRR 508

  Fly  1646 LHENLQIVSPS--LPQLMNVVNGADCVSMYSVDKCWYRA---KIIDAELMVLLFIDYGNTDCVSD 1705
            .:.| |:||..  :|:.. :..|..|....|.||.|||.   ::::.:.:.:.:.|:||...|.
Human   509 CYSN-QLVSDRYVMPECF-IQPGHLCCVRISEDKWWYRVIIHRVLEKQEVEVFYPDFGNIGIVQ- 570

  Fly  1706 ATDIKESM------WSHIEPFCLPCALP-IRPKGTADWVDAANGIFNESYSKVPRLEYLTQGDHY 1763
                |.|:      ::.:....:||:|. :||. ...|...|...|.:.....|.:..:   |.|
Human   571 ----KSSLRFLKCCYTKLPAQAIPCSLAWVRPV-EEHWTSKAILQFQKLCGLKPLVGVV---DEY 627

  Fly  1764 TTSYVNMYI----DGEDVAKKLIADGFARPLEYLASGCSCYISHVNGICDFFIQLERDSKALELI 1824
            ....:|:::    ..|||                      |..||         |..:..|:...
Human   628 VDGILNIFLCDTSSNEDV----------------------YFHHV---------LRTEGHAIVCR 661

  Fly  1825 ELYLRKK-DTLKPL------EGFEKGLIVAALFEDDELWYRAQLQKELPDSRYEVLFI------- 1875
            |....|. ..|.||      .|..:.:::..|....:..|..:.:|..|.|:...|.|
Human   662 ENISSKGFSELNPLALYTTSSGGPEDIVLTELGYPSQQHYFNEDRKISPQSKESELRILQDINDE 726

  Fly  1876 -DYGNTSTTSKCLMLSEEIASLPSLSKKCSLQLPDAYISWS-PEAEAKFAELTGEGELVFTTQLL 1938
             ...:..:.||..:...|..||    |.|:....:. ..|| ||..    :|..|.|....|.:
Human   727 KSLSHLKSESKEPLKDSEFESL----KTCNKSFEED-PKWSNPEPN----DLKEENEDEIPTGM- 781

  Fly  1939 KPGQDHVTIDLLLDGENIID-RLLPLCQRKEPKEASKESLAVTTKAIITHVENTSRIYLQFSEKD 2002
             |..:.|||     |::|.| ..||| |.|..|..                             |
Human   782 -PCLESVTI-----GDDIWDENWLPL-QAKMGKGG-----------------------------D 810

  Fly  2003 SLMDIICEKLNGSKLQPKTEKAAVDDMCVVQFA------DD------------LEFYRSRILEVL 2049
            :...:....|.|.......::....|.|   |:      ||            :|.::..:|...
Human   811 AASHLFTASLGGKNQYSSCKEMPQKDWC---FSTPKDTWDDSWQPSGLVNGTKVEVHKPEVLGAQ 872

  Fly  2050 EDD------QYKVILIDYGNTTVVDKLYELPQEFTLIKPVAEICSMEPSAIFEKNKALTLTT--- 2105
            |.:      |.::.:....:::.:.||.|.....|..:..|:....||:....:.|.:.|:|
Human   873 EKNTGTNRTQKQLDINGSSDSSTLPKLEEFCTSLTQSEQSADGSQSEPNNSQTQPKQIQLSTAAP 937

  Fly  2106 --FDALLDSC-KGVVAVEFVNKSASPPVVR---------LTT-KDKRSLKIYEHLQKLVQAELKL 2157
              ..|:.||. |...:||     :||.:::         :|. ||||...: :.|..::..|.::
Human   938 CSTTAVDDSAEKPSGSVE-----SSPEILKNEDFSSSRAITLYKDKRQESV-DQLSLILSYECQI 996

  Fly  2158 IQK 2160
            .||
Human   997 SQK 999

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tud	NP_476773.1	DUF1421	198..>397	CDD:284607
		TUDOR	406..524	CDD:278965
		TUDOR	454..510	CDD:197660
		TUDOR	591..707	CDD:278965
		TUDOR	644..693	CDD:197660
		TUDOR	1012..1132	CDD:278965
		TUDOR	1062..1119	CDD:197660
		TUDOR	1309..1425	CDD:278965	20/117 (17%)
		TUDOR	1354..1411	CDD:197660	5/56 (9%)
		TUDOR	1614..1727	CDD:278965	31/144 (22%)
		TUDOR	1666..1711	CDD:119391	12/47 (26%)
		TUDOR	1791..1906	CDD:278965	25/129 (19%)
		TUDOR	1843..1886	CDD:119391	8/50 (16%)
		TUDOR	1975..2089	CDD:278965	17/137 (12%)
		TUDOR	2028..2069	CDD:119391	9/64 (14%)
		TUDOR	2159..2277	CDD:278965	2/2 (100%)
		TUDOR	2210..2264	CDD:197660
		TUDOR	2345..2458	CDD:278965
		TUDOR	2396..2437	CDD:119391
TDRD5	NP_001186014.1	LOTUS_1_TDRD5	4..98	CDD:193599
		LOTUS_2_TDRD5	132..201	CDD:193589	17/77 (22%)
		LOTUS_3_TDRD5	296..369	CDD:193590	11/74 (15%)
		TUDOR	471..594	CDD:278965	27/129 (21%)
		TUDOR	529..575	CDD:119391	14/50 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900