Protein Alignment tud and TDRD5

DIOPT Version :10

• Sequence 1: NP_476773.1
• Gene: tud / 37417
• FlyBaseID: FBgn0003891
• Length: 2515
• Species: Drosophila melanogaster
• Sequence 2: NP_001186014.1
• Gene: TDRD5 / 163589
• HGNCID: 20614
• Length: 1035
• Species: Homo sapiens
• Alignment Length: 1043
• Identity: 208/1043 - (19%)
• Similarity: 354/1043 - (33%)
• Gaps: 288/1043 - (27%)

  Fly  1252 VKSNPNLARRFKEFYEGKSFALNVKNVCENNIVHLRPVMPLFME-DRRSFICPYPVVLSSFQALV 1315
            :.|.|...||..  |.|:                :.|::|..:: :.:..:...||:||.|:...
Human   111 IYSGPRSHRRVP--YRGR----------------VAPILPAVVKSELKDLLALSPVLLSDFEKAF 157

  Fly  1316 VYTAKPYRVYVQPQAIVPSMQTLLDNMYEHYKAKGD--SLKKFDVGQICAVRSSDGNWYRARISG 1378
               ||.:....|      .||....:|:|...|..|  |:::...|.:..::.|       ....
Human   158 ---AKRFGRSFQ------YMQYGFLSMFEVLNAASDVISVEQTRAGSLLMLKKS-------VTEE 206

  Fly  1379 KDSNAACFEVFYIDYGNTEEIKRDDIKALDAKFYEHASGFAVEINLPIGRP--SNDTKLKARISE 1441
            |.......::|      |:..:        .|...:::||      |:.:|  |..|.......:
Human   207 KPRGCPAGKIF------TQPFR--------MKQGSYSTGF------PVAKPCFSQPTSNMEPPKQ 251

  Fly  1442 ILE-EKVVTIKSIEVRR-SHLIADVILENN-QSVI-----------DLLKAEKLVPGK------- 1485
            |:. ||...:..:|..| :|......|||. :|||           :|....|.|..|
Human   252 IMSMEKTSKLNVVETSRLNHTEKLNQLENTFKSVIAQIGPGGTISSELKHKIKFVVSKFPEGLFI 316

  Fly  1486 -----DLDYMRKQMEKGKSRTY----EYIETVDLTLDEEEDKGRKETVSKSGSANASPKKKQHND 1541
                 :.:.:.|:....|...:    |.:..:...|..|..||.::.:  ...|:..|.....:|
Human   317 SKLLGEYEVIFKEQLSPKKLGFLNVTELVGALSDILHVEFRKGHQDLL--VFDADKKPLPPVQSD 379

  Fly  1542 KDREPK---KSKPAEPARTVAPQPVALKTPSPVPAEPAP--VPKPATPVPEVVEVPEINPTVREA 1601
            |..|.|   .|.|.....|.|.:......||....||..  ..||...|..:....|.|.:....
Human   380 KKIEAKACVSSPPRNSLSTAAVKETVWNCPSKKQKEPQQKICKKPNLVVKPLQLQVETNKSELNL 444

  Fly  1602 AAESKQAPAQEDPYKDLDC------------VVLSHCDNPAQFYVHPI---------DQLSKLNQ 1645
            |..:...|....|.|.| |            |.:.:..:|:|||:...         |.:.::.:
Human   445 AMANHDIPPDAVPNKKL-CRLPPLDTSSLIGVFVEYIISPSQFYIRIYSRDSSELLEDMMIEMRR 508

  Fly  1646 LHENLQIVSPS--LPQLMNVVNGADCVSMYSVDKCWYRA---KIIDAELMVLLFIDYGNTDCVSD 1705
            .:.| |:||..  :|:.. :..|..|....|.||.|||.   ::::.:.:.:.:.|:||...|.
Human   509 CYSN-QLVSDRYVMPECF-IQPGHLCCVRISEDKWWYRVIIHRVLEKQEVEVFYPDFGNIGIVQ- 570

  Fly  1706 ATDIKESM------WSHIEPFCLPCALP-IRPKGTADWVDAANGIFNESYSKVPRLEYLTQGDHY 1763
                |.|:      ::.:....:||:|. :||. ...|...|...|.:.....|.:..:   |.|
Human   571 ----KSSLRFLKCCYTKLPAQAIPCSLAWVRPV-EEHWTSKAILQFQKLCGLKPLVGVV---DEY 627

  Fly  1764 TTSYVNMYI----DGEDVAKKLIADGFARPLEYLASGCSCYISHVNGICDFFIQLERDSKALELI 1824
            ....:|:::    ..|||                      |..||         |..:..|:...
Human   628 VDGILNIFLCDTSSNEDV----------------------YFHHV---------LRTEGHAIVCR 661

  Fly  1825 ELYLRKK-DTLKPL------EGFEKGLIVAALFEDDELWYRAQLQKELPDSRYEVLFI------- 1875
            |....|. ..|.||      .|..:.:::..|....:..|..:.:|..|.|:...|.|
Human   662 ENISSKGFSELNPLALYTTSSGGPEDIVLTELGYPSQQHYFNEDRKISPQSKESELRILQDINDE 726

  Fly  1876 -DYGNTSTTSKCLMLSEEIASLPSLSKKCSLQLPDAYISWS-PEAEAKFAELTGEGELVFTTQLL 1938
             ...:..:.||..:...|..||    |.|:....:. ..|| ||..    :|..|.|....|.:
Human   727 KSLSHLKSESKEPLKDSEFESL----KTCNKSFEED-PKWSNPEPN----DLKEENEDEIPTGM- 781

  Fly  1939 KPGQDHVTIDLLLDGENIID-RLLPLCQRKEPKEASKESLAVTTKAIITHVENTSRIYLQFSEKD 2002
             |..:.|||     |::|.| ..||| |.|..|..                             |
Human   782 -PCLESVTI-----GDDIWDENWLPL-QAKMGKGG-----------------------------D 810

  Fly  2003 SLMDIICEKLNGSKLQPKTEKAAVDDMCVVQFA------DD------------LEFYRSRILEVL 2049
            :...:....|.|.......::....|.|   |:      ||            :|.::..:|...
Human   811 AASHLFTASLGGKNQYSSCKEMPQKDWC---FSTPKDTWDDSWQPSGLVNGTKVEVHKPEVLGAQ 872

  Fly  2050 EDD------QYKVILIDYGNTTVVDKLYELPQEFTLIKPVAEICSMEPSAIFEKNKALTLTT--- 2105
            |.:      |.::.:....:::.:.||.|.....|..:..|:....||:....:.|.:.|:|
Human   873 EKNTGTNRTQKQLDINGSSDSSTLPKLEEFCTSLTQSEQSADGSQSEPNNSQTQPKQIQLSTAAP 937

  Fly  2106 --FDALLDSC-KGVVAVEFVNKSASPPVVR---------LTT-KDKRSLKIYEHLQKLVQAELKL 2157
              ..|:.||. |...:||     :||.:::         :|. ||||...: :.|..::..|.::
Human   938 CSTTAVDDSAEKPSGSVE-----SSPEILKNEDFSSSRAITLYKDKRQESV-DQLSLILSYECQI 996

  Fly  2158 IQK 2160
            .||
Human   997 SQK 999

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tud	NP_476773.1	TUDOR	411..524	CDD:425754
		TUDOR	595..707	CDD:425754
		TUDOR	1016..1132	CDD:425754
		TUDOR	1309..1425	CDD:425754	20/117 (17%)
		TUDOR	1620..1727	CDD:425754	28/138 (20%)
		TUDOR	1795..1906	CDD:425754	25/125 (20%)
		TUDOR	1980..2089	CDD:425754	17/132 (13%)
		TUDOR	2163..2277	CDD:425754
		TUDOR	2347..2458	CDD:425754
TDRD5	NP_001186014.1	LOTUS_1_TDRD5	4..98	CDD:193599
		LOTUS_2_TDRD5	132..201	CDD:193589	17/77 (22%)
		LOTUS_3_TDRD5	296..369	CDD:193590	11/74 (15%)
		Tudor_TDRD5	476..593	CDD:410490	26/123 (21%)