Protein Alignment tud and tdrd6

DIOPT Version :10

• Sequence 1: NP_476773.1
• Gene: tud / 37417
• FlyBaseID: FBgn0003891
• Length: 2515
• Species: Drosophila melanogaster
• Sequence 2: XP_031758870.1
• Gene: tdrd6 / 105948404
• XenbaseID: XB-GENE-5969988
• Length: 2499
• Species: Xenopus tropicalis
• Alignment Length: 2572
• Identity: 475/2572 - (18%)
• Similarity: 845/2572 - (32%)
• Gaps: 924/2572 - (35%)

  Fly   327 AQPYVPKANPRSQY-TYYNVRMNKPINAMPPPAGPHVPIQHFNQQANNVSLSYVPARFTPPPTPS 390
            |:|: |.|:.||.. ||:              ||.|...|.....:...|....|.....|....
 Frog   206 AKPF-PAASFRSLIDTYF--------------AGGHSSAQTKTFPSVQPSAQSNPMAQVNPRRAW 255

  Fly   391 IAQHQIPIPAFRTTSLTVGLTYDVVISYVENGPYLFWVHLKSSDHDLSTMMGQI----------- 444
            :..:..|       ...||:...|:::.|.| |:..:..|:|..|::..:...:
 Frog   256 VLDYFYP-------QFQVGVIEPVLVTEVSN-PHRIFCQLRSLSHEVQRLSDSMHHFYELQSGCG 312

  Fly   445 ERTKLKALAQAPELGTACVARFSEDGHLYRAMVCAVYAQR--YRVVYVDYGNSELLS-------A 500
            ||..::.|..    |..|..|.| |||.||:::...|..:  ..|::||:|..:::|       |
 Frog   313 ERNYIQPLIP----GQPCACRGS-DGHWYRSLLQEYYPDKKLAMVIHVDWGRKDIVSMNCLRTLA 372

  Fly   501 SDLFQIPPELLEIKPFAFRFALAGTKE----IEP-IDDSMKRIFK------KSAIYRNFE----L 550
            :|.|::|       ...|..:|.|..:    .:| |...::.:|:      |...|.::|    :
 Frog   373 ADYFRMP-------VVTFPCSLYGVSDGGVAWDPAIIMELRNMFQGKQFSAKIDFYNSYEHMYVV 430

  Fly   551 TVQAPESVGSMQTCHLNQN---GTN---------MLELLRQLKNSRQSYKKAEQ----------- 592
            |:...:.|        |.|   ||.         ...|.:.|..|::..|...|
 Frog   431 TLYGDDGV--------NLNCVFGTRAQSFSFSQAQKPLSQDLGESQEDVKSLPQTPPEAFYVPTV 487

  Fly   593 ------LENDDAVEIRFIDSPSNFYVQKVANIGKFEQLMDEMFSYYNANQRVPDQL---ILGAPC 648
                  :.....|.:.|:..||||:::...|..|:.::|:::.:.|:...::...:   :.|..|
 Frog   488 PVAELNISTFYDVLVEFVADPSNFWIRTGENATKYSEMMEQIAALYSKASKLDGIMTTPMAGQLC 552

  Fly   649 IVKC-DQEWYRAEILRVDDSVI-VRHVDFGYEQNVKRHLIGHIAEKHLEMPRQAIKCCLKGFENS 711
            ..|. |..:|||||:.:...:: |..:|.|..:.|..:.:..:..:..|||..||.|
 Frog   553 CTKFKDDRFYRAEIVAIKGKMVEVYFIDHGNTELVDWYNVKKLPAELGEMPGLAIYC-------- 609

  Fly   712 ELSEDKITDQFEMLAEESNIRRRTFSVRIFRIEPDGLNVVNLLAKNLNVMKK---LYKLSMPFEQ 773
                 .:.|.:.:                    .|..:...:||..:.|:.|   :|.||....:
 Frog   610 -----SVADTYPL--------------------GDSWSPEAILAFKMAVVDKRLVIYVLSKEHNK 649

  Fly   774 YLSLEKGQFNANNTRAESVISSELNKSHILNSTSIGETENRLQEQEKEQQQKKVDVRQQQLAVEI 838
            |: :|.    .:|:|.|              ..|:|:..:.:...:.|:
 Frog   650 YI-IEV----LDNSRIE--------------QRSVGKILSAVGHAKYEE---------------- 679

  Fly   839 PQAVKSVSGSKNSTDWDKRSSTSAGSKDSKRQQQQQIQRIDRHLDFSCETQSTGSYSSGMSSPRK 903
               |:.|:....:|            .|..|:.|||.                    ||
 Frog   680 ---VEPVAQHPGTT------------SDIDRKMQQQF--------------------SG------ 703

  Fly   904 GNRQQNGRTPIQSPRHNEKQEAKKNARFSNSESPRRSRDGQQGNQRSQNAPQGYAQKPQRQKSTL 968
                           |..|..:...|                                 |||
 Frog   704 ---------------HLNKDISLLKA---------------------------------RQK--- 717

  Fly   969 DGNISSKRSSGVGSDIASSSSESVAAAKPEKYVSLDKPYALQEMKTPSKEAASLSWWLSPFQFYI 1033
                          ::..|..|:    |.|.|    .|:..|..:..:.....:|..::|..|:.
 Frog   718 --------------EVVCSVQEN----KSEPY----SPFEDQFFEPGTTIEVVVSCIINPSLFWC 760

  Fly  1034 VPKSVSAKYDNIMRDMREFYRQKQHQPLQLKVGST-------VVVRQRKDNAILRATV------- 1084
            .....|||.:.:|..:         |.:.|..|.:       .:.:...|....||.:
 Frog   761 QNALHSAKLEKLMAKI---------QDICLNAGCSYERGACACLAKSSCDGRWYRAFIVNEMPAG 816

  Fly  1085 -TACNHMMRKYRVFCVDTGSLITVTSEDIWQLEQRFADPPCMAHRCSFHSVVT-------NYDPL 1141
             .:.:|:    .|..||.|...||:.:|:..:|.........|.:||.::::.       .:|.:
 Frog   817 KASSDHV----EVLFVDYGIRETVSLKDLRCMESELFGLKAQAFKCSLYNIIAPDGENPFEWDAI 877

  Fly  1142 YIVDRMETFVPVNAKVDCEFVSKEKSNQGSNTSSTCSY------TVNIFVNGASLRDMLVKAEFL 1200
                   |.:..|..||.  .||:.:.......:|.|:      .|::|...||:..:||:....
 Frog   878 -------TTLSFNRFVDS--FSKKTTEFKCTFFATASFKKELFNVVDVFTPFASICKLLVEQGHA 933

  Fly  1201 TEVAPEIRVNLLAGQQIRGKFTSIRDMTSFKVQFDYGNNVNFLCTYDDAKFVKSNPNLARRFKEF 1265
            .:::..   .|:...|::..:.|..|:   |:    |.......||.::..            ||
 Frog   934 KQLSHR---TLVPSVQLQTYYYSTHDI---KI----GGEEEVYITYVNSSL------------EF 976

  Fly  1266 YEGKSFALNVKNVCENNIVHLRPVMPLFMEDRRSFICPYPVVLSSFQALVVYTAKPYRVYVQPQA 1330
            |            |:                           ||.              ..:...
 Frog   977 Y------------CQ---------------------------LSR--------------NTETMD 988

  Fly  1331 IVPSMQTLLDNMYEHYKAKGDSLKKFDV--GQICAVRSSDGNWYRARISGKDSNAACF------- 1386
            ::.|..|.:.|          .:|||.:  |.:|..:.||..|||           ||
 Frog   989 MIASATTRVCN----------EVKKFQLSPGSLCLAKFSDQQWYR-----------CFTNFNKNS 1032

  Fly  1387 -EVFYIDYGNTEEIKRDDIKALDAKFYE--HASGFAVEI------------------NLPIGRP- 1429
             :||::||||||::.::::..:.:..||  |....|::.                  ||.:.:|
 Frog  1033 TDVFFVDYGNTEKLTKEELLPIPSDAYELLHFPMQAIKCSLSDIPDTIPREVVLWFENLILDKPL 1097

  Fly  1430 -------SNDTKLKARISEILEEKVVTIKSIEVR----------------RSHLIADV------- 1464
                   ..|.||   |.|:.:.......||:.:                :.|.:.|:
 Frog  1098 KALIVAKETDGKL---IVELYDGSQQINSSIKAKLGLKNPRTEGYFGNAEKRHQLNDLDKGGRPD 1159

  Fly  1465 --------------ILEN-NQSVIDLLKAEKLVPGKDLDYMRKQMEKGKSRTYEYIETVDLTLDE 1514
                          .|:| :|:.....|:...| .|:.|...::.....||.|         :.:
 Frog  1160 SAFKLYNQGSKFSSDLDNHSQNGFTHQKSASFV-AKERDQFEQKPNLRTSRPY---------IQD 1214

  Fly  1515 EEDKGRKETVSKSGSANASPKKK-QHNDKDREPKKSKPAEPARTVAPQPVALKTPSPVPAEPAPV 1578
            .|....::.:|:||.|   |.|. :...||||..:.:|            .||| |.:.::...|
 Frog  1215 REVYSVRKNISQSGYA---PHKTGEFRSKDREALEQRP------------NLKT-SGMYSQGREV 1263

  Fly  1579 PKPATPVPEVVEVPEINPTVREAAAESKQAPAQEDPYKDLDCVVLSHCDNPAQFYVHPIDQLSKL 1643
                              ::.:..:.|...|.:...::..:..|..|..||..|..:  :|.||:
 Frog  1264 ------------------SMSQNGSNSGFPPKKTGGFRSKEREVSEHKQNPDAFKGY--NQESKM 1308

  Fly  1644 NQLHENLQIVSPSLPQLMNVVNGADCVSMYSVDKCWYRAKIIDAELMVLLFIDYGNTDCVSDATD 1708
            :             |||.   ||:...:.:|.:                           ||.:.
 Frog  1309 S-------------PQLR---NGSQMEASWSSE---------------------------SDRSS 1330

  Fly  1709 IKESMWSHIEPFCLPCALPIRPKGTADWVDAANGIFNESYSKVPRLEYLTQGDHYTTSYVNMYID 1773
                  .|            :|:..|.  ......|.|..| :|.|..|:
 Frog  1331 ------EH------------KPEINAS--QQRRSTFQECKS-IPPLTKLS--------------- 1359

  Fly  1774 GEDVAKKLIADGFARPLEYLASGCSCYISHVNGICDFFIQLERDSKALELIELYLRKKDTLKPLE 1838
              |:.|:.|..||.         .|.||||.|.:.||::|:.:|::...:.|:...:|   ||.:
 Frog  1360 --DLPKQNITPGFK---------SSVYISHTNTLSDFYVQIAQDTELSNISEILNNEK---KPSD 1410

  Fly  1839 GFEK-----GLIVAALFEDDELWYRAQLQKELPDSRYEVLFIDYGNTST--TSKCLMLSEEIASL 1896
            ..::     |.::.|.||||.|:|||.:.::..|. .:|.:||||||.|  .|:...|...::|.
 Frog  1411 RLDEKDVNLGDLICAFFEDDGLYYRAVITEKHSDG-LQVQYIDYGNTLTIPASQIYKLPPSLSSA 1474

  Fly  1897 PSLSKKCSL----------QLPDAYISWSPEAEAKFAELTGEGELVFTTQLLKPGQDHVTIDLLL 1951
            |.:|..|:|          .:.|..:        ||:|.||:.||  :.:.::.......: :|.
 Frog  1475 PVMSIFCALDKCTTAACEQNMDDLMV--------KFSERTGDLEL--SCEFVQCNNLKWNV-ILC 1528

  Fly  1952 DGENII--------DRLLPLCQRKEPKEASKE------------SLAVTTKAIITHVENTSRIYL 1996
            |.:..|        |.||.....:||...|::            :|....:|..:.|::....:.
 Frog  1529 DDQGCINDLFISASDPLLNPPSLEEPDVTSEQLNGVSHYVWNLPALGERVEAYASAVDSPEHFWC 1593

  Fly  1997 QF--SEKDSLMDIICE----KLNGSKLQPKTEKAAVDDMCVVQFADDLEFYRSRILEVLEDDQYK 2055
            |.  ::.|||...:.|    .::..|...:.|   |...|.|.:::|..:||:.:.:: |.||..
 Frog  1594 QLVTADVDSLAVKVQEAGERSVHDGKFSTEIE---VGSPCNVIYSEDNHWYRAAVTKI-EADQVT 1654

  Fly  2056 VILIDYGNTTV--VDKLYELPQEFTLIKPVAEICSM------------EPSAIFEKNKALTLTTF 2106
            |..:||||..:  ::::..||.:...|...|..||:            :.:..|.:|....|...
 Frog  1655 VRFVDYGNEEMLHLEQVRRLPADLATIPAQAFSCSLAGFNLSEGCWNSDANTFFYENVTEGLLVI 1719

  Fly  2107 DAL----LDSCKGVVAVEFVNKSASPPVV------------RLTTKDKRSLKIYEHLQKLVQ--- 2152
            ..|    |..||  :....||.|.:...|            .:.|....||    |.:::::
 Frog  1720 SVLHIQELGPCK--IPQASVNVSYNGENVNTKMRQFWQDSNEIPTPFLESL----HAEEIIKDNT 1778

  Fly  2153 ---AELKLIQKRNENSE--CIISYGNSPKSFYVQMKHNSAD---LDLIVKT-LQSLKKEKLKKLI 2208
               ..::.:..::|.||  |......:|.   |...:::||   :..|.:| |::|......:..
 Frog  1779 IPSQAVEDVADQSEQSEEPCASELTETPT---VPTMYSNADGEEVTAIDETKLEALPLSSTDEAA 1840

  Fly  2209 DPTTN------------------SNGVC----------------YSQEDAC--YYRCSIKSVLDP 2237
            :.|.|                  |:..|                .:.||.|  |...:||....
 Frog  1841 ESTENTDVDLMRTECLLPEIQKSSDLSCLELTLDEDVPGSAVTPLAPEDLCIDYDESNIKESYS- 1904

  Fly  2238 SQGFEVFLLDYGNTLVVPEV--WQLPQEIEPIPSLALHCQLSKIPMDVS-----DEKLEEAFAAL 2295
                ::..:|.|......::  |......:.|.|..:   :..:|:|..     .|..||:.|:.
 Frog  1905 ----DITAMDQGELHHTEDIDLWTPAAHDQEIASSEI---IDNVPIDKECDYSVQEPTEESSAST 1962

  Fly  2296 -LEQHFGELYEITTQPNEDETKPLIAELRINYKDFVQELVSTVT--------------------- 2338
             ||:.........|: |.|..:|..|.|:...::::....|||.
 Frog  1963 GLEEGPAPEKNAFTE-NNDGLEPEAANLQSKGEEYLVPEESTVAVCESEDFEPEVDVDLPRKENE 2026

  Fly  2339 ----------------GVQKPLEAELH---------------------NCVVVQFDGPMSFYVQM 2366
                            |:..|.||..|                     .|....||
 Frog  2027 DLPAYTYIPIPEDDGDGLGSPKEATSHEIGDAEGLGEQNQELLDHTISECTNDDFD--------- 2082

  Fly  2367 ESDVPALEQ---------------MTDKLLDAEQDLPAFSDLKEGALCVAQFPEDEVFYRAQIRK 2416
              |:|:.||               ..|...|.:.|:.|.....:..:.:.:.|..|..||:...|
 Frog  2083 --DLPSKEQEGIPLHSDADTDFAGTEDVPRDMKGDIEATGSQNKEDVTLGEDPATETEYRSYFLK 2145

  Fly  2417 VLDDGKCEVHFIDFG---NNAVTQQFRQLPEELAKPARYSRHCELDASTISKCDAALLQSFIDTR 2478
            ..|..:......||.   .|.|.:..    .::::|.......|....|::..|...|:..:|.
 Frog  2146 AEDVDRPSQEHKDFAGQEENPVAEYI----NDISEPEFADLQSEEQGDTVTYTDTPFLEGGVDD- 2205

  Fly  2479 FSETFQVEILATKGTGTHVVRLFYQSKNISEKLQECQ 2515
            |..|   |..:...|..||..   ..::::.:.||.|
 Frog  2206 FGST---EAKSRDNTYEHVTE---DVEDLNTENQESQ 2236

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tud	NP_476773.1	TUDOR	411..524	CDD:425754	31/132 (23%)
		TUDOR	595..707	CDD:425754	29/116 (25%)
		TUDOR	1016..1132	CDD:425754	25/130 (19%)
		TUDOR	1309..1425	CDD:425754	29/145 (20%)
		TUDOR	1620..1727	CDD:425754	17/106 (16%)
		TUDOR	1795..1906	CDD:425754	40/127 (31%)
		TUDOR	1980..2089	CDD:425754	28/116 (24%)
		TUDOR	2163..2277	CDD:425754	27/157 (17%)
		TUDOR	2347..2458	CDD:425754	23/149 (15%)
tdrd6	XP_031758870.1	Tudor_SF	24..153	CDD:470623
		Tudor_TDRD6_rpt2	258..389	CDD:410492	34/150 (23%)
		Tudor_SF	497..630	CDD:470623	33/165 (20%)
		Tudor_SF	734..863	CDD:470623	26/141 (18%)
		Tudor_SF	950..1073	CDD:470623	39/215 (18%)
		Tudor_SF	1371..1483	CDD:470623	39/124 (31%)
		Tudor_SF	1578..1717	CDD:470623	31/142 (22%)