DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pu and Gch1

DIOPT Version :9

Sequence 1:	NP_726038.1	Gene:	Pu / 37415	FlyBaseID:	FBgn0003162	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_077332.1	Gene:	Gch1 / 29244	RGDID:	61992	Length:	241	Species:	Rattus norvegicus

Alignment Length:	261	Identity:	155/261 - (59%)
Similarity:	184/261 - (70%)	Gaps:	34/261 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 GTPVEEVAPAPALVPLAGNQRPRLILKTNGSSPDSDGTQPKTPL---TPRTSTTPGHEKCTFHHD 127
            |.|..|: |.|.....|...||          |::.|.||....   .||:           ..|
  Rat    12 GFPEREL-PRPGASRPAEKSRP----------PEAKGAQPADAWKAGRPRS-----------EED 54

  Fly   128 LELDHKPPTREALLPDMARSYRLLLGGLGENPDRQGLIKTPERAAKAMLYFTKGYDQSLEDVLNG 192
            .||:         ||::|.:|..:|..|||:|.||||:|||.|||.||.:|||||.:::.||||.
  Rat    55 NELN---------LPNLAAAYSSILRSLGEDPQRQGLLKTPWRAATAMQFFTKGYQETISDVLND 110

  Fly   193 AVFDEDHDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPCNKILGLSKLARIVEIFSRRLQVQER 257
            |:|||||||||:||||:||||||||||||.|:|.|||||..::||||||||||||:|||||||||
  Rat   111 AIFDEDHDEMVIVKDIDMFSMCEHHLVPFVGRVHIGYLPNKQVLGLSKLARIVEIYSRRLQVQER 175

  Fly   258 LTKQIAVAVTQAVQPAGVAVVVEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFLNLVN 322
            ||||||||:|:|:|||||.||:|..|||||||||||:||||||||||||||:|||||||||.|:.
  Rat   176 LTKQIAVAITEALQPAGVGVVIEATHMCMVMRGVQKMNSKTVTSTMLGVFREDPKTREEFLTLIR 240

  Fly   323 S 323
            |
  Rat   241 S 241

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pu	NP_726038.1	GTP_cyclohydro1	141..323	CDD:238349	137/181 (76%)
Gch1	NP_077332.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58		16/67 (24%)
Gch1	NP_077332.1	GTP_cyclohydro1	57..241	CDD:238349	138/192 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341481
Domainoid	1	1.000	279	1.000	Domainoid score	I1628
eggNOG	1	0.900	-	-		E1_COG0302
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H132
Inparanoid	1	1.050	289	1.000	Inparanoid score	I2732
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D529046at33208
OrthoFinder	1	1.000	-	-		FOG0002669
OrthoInspector	1	1.000	-	-		oto98872
orthoMCL	1	0.900	-	-		OOG6_101153
Panther	1	1.100	-	-	O	PTHR11109
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2044
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760