DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pu and cat-4

DIOPT Version :9

Sequence 1:	NP_726038.1	Gene:	Pu / 37415	FlyBaseID:	FBgn0003162	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_505710.1	Gene:	cat-4 / 179472	WormBaseID:	WBGene00000298	Length:	223	Species:	Caenorhabditis elegans

Alignment Length:	234	Identity:	146/234 - (62%)
Similarity:	175/234 - (74%)	Gaps:	21/234 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 LKTNGSSPDSDGTQPKTPLTPRTSTTPGHEKCTFHHDLELDHKPPTREALLPDMARSYRLLLGGL 155
            |.::.:|..|:  ..|..:..|..|.|           :.||        |..|..:|:.::..:
Worm    11 LSSDAASVGSE--DDKVEMKKRNGTIP-----------KEDH--------LKSMCNAYQSIIQHV 54

  Fly   156 GENPDRQGLIKTPERAAKAMLYFTKGYDQSLEDVLNGAVFDEDHDEMVVVKDIEMFSMCEHHLVP 220
            ||:.:||||:||||||||||:.||||||..|:::||.|||||||||||:||||||||:|||||||
Worm    55 GEDINRQGLLKTPERAAKAMMAFTKGYDDQLDELLNEAVFDEDHDEMVIVKDIEMFSLCEHHLVP 119

  Fly   221 FYGKVSIGYLPCNKILGLSKLARIVEIFSRRLQVQERLTKQIAVAVTQAVQPAGVAVVVEGVHMC 285
            |.|||.|||:|..|:|||||||||||:||||||||||||||||.|:.|||||:|||||:|..|||
Worm   120 FMGKVHIGYIPNKKVLGLSKLARIVEMFSRRLQVQERLTKQIATAMVQAVQPSGVAVVIEASHMC 184

  Fly   286 MVMRGVQKINSKTVTSTMLGVFRDDPKTREEFLNLVNSK 324
            ||||||||||:.|.||.||||||||||||||||||:|.:
Worm   185 MVMRGVQKINASTTTSCMLGVFRDDPKTREEFLNLINKR 223

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pu	NP_726038.1	GTP_cyclohydro1	141..323	CDD:238349	136/181 (75%)
cat-4	NP_505710.1	GTP_cyclohydro1	38..222	CDD:238349	138/191 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159654
Domainoid	1	1.000	276	1.000	Domainoid score	I927
eggNOG	1	0.900	-	-		E1_COG0302
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H132
Inparanoid	1	1.050	283	1.000	Inparanoid score	I1738
Isobase	1	0.950	-	0	Normalized mean entropy	S627
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D529046at33208
OrthoFinder	1	1.000	-	-		FOG0002669
OrthoInspector	1	1.000	-	-		oto17230
orthoMCL	1	0.900	-	-		OOG6_101153
Panther	1	1.100	-	-	LDO	PTHR11109
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R477
SonicParanoid	1	1.000	-	-		X2044
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740