DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Xpd and CHL1

DIOPT Version :9

Sequence 1:	NP_726036.2	Gene:	Xpd / 37414	FlyBaseID:	FBgn0261850	Length:	769	Species:	Drosophila melanogaster
Sequence 2:	NP_015317.1	Gene:	CHL1 / 856099	SGDID:	S000005929	Length:	861	Species:	Saccharomyces cerevisiae

Alignment Length:	717	Identity:	176/717 - (24%)
Similarity:	308/717 - (42%)	Gaps:	161/717 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 KLIYCSRTVPEIEKVIAELQNLMVYYERHCPN-PPPFTG---------LVLSSRKNMCIHPEVSK 123
            |:.|.|||..::.:..::|:         .|: |..|..         |.|:|:|.:||:|:|.|
Yeast   232 KIYYASRTYSQLGQFTSQLR---------LPSFPSSFRDKVPDEKVKYLPLASKKQLCINPKVMK 287

  Fly   124 EREGKAVDGKCYGLTASYIRERHEMDTETPICQYFEGFSLEGKE--STLPV------GVYSIDDL 180
            .:..:|::..|..|       ||..:.    |.:::..: |.:.  .||.:      .:..|:||
Yeast   288 WKTLEAINDACADL-------RHSKEG----CIFYQNTN-EWRHCPDTLALRDMIFSEIQDIEDL 340

  Fly   181 KEYGRSRNWCPYFLARYAIAHAHIVVYSYHYLLDPKIAQVVSKEMSRE-SCVVFDEAHNIDNVCI 244
            ...|:|...|||:.:|.|:..|.:|...|.|||......  |.:::.| |.|:.|||||:    |
Yeast   341 VPLGKSLGICPYYASREALPIAEVVTLPYQYLLSESTRS--SLQINLENSIVIIDEAHNL----I 399

  Fly   245 DSM-SVKINRRTVERSTNA----LNHLTKLVQDIREEDTNRLN---------EEYQRMVQGLKDA 295
            ::: |:..::.::|...|.    :.:..|...  |....||:|         ...|.:|:..|..
Yeast   400 ETINSIYSSQISLEDLKNCHKGIVTYFNKFKS--RLNPGNRVNLLKLNSLLMTLIQFIVKNFKKI 462

  Fly   296 SVQRDTDMILANPVLPNDVLTEVVPGNIRNADHFLSFLRRFIEYIKTRLRVHHVVQESPAGFLKD 360
            ..:.|          |||:.|   ..||...:     :.:.:.|||.....:.:...:.|  ||:
Yeast   463 GQEID----------PNDMFT---GSNIDTLN-----IHKLLRYIKVSKIAYKIDTYNQA--LKE 507

  Fly   361 ISS-----------KICIERKPLRFCAERLSSLLRTLEISDLTEYGALTLITHFATLVSTYTKGF 414
            ..|           |..:..:||.|   ::|..|..|  ::||..|..
Yeast   508 EESSKNENPIKETHKKSVSSQPLLF---KVSQFLYCL--TNLTSEGQF----------------- 550

  Fly   415 TIIIEPFDDKTPTVSNPILHFSCLDSSIAMAPVFSRFQTVVITSGTLSPMDMYPKILDFDPVVMS 479
                  |.:|     |..:.:..|:.|.....:.::.:.||:..||:.||..:  :.:..|.|.|
Yeast   551 ------FFEK-----NYSIKYMLLEPSKPFESILNQAKCVVLAGGTMEPMSEF--LSNLLPEVPS 602

  Fly   480 SFTMTLARPCLLPMIVSKGNDQVTISSK------FETREDTAVIRNY-GQLLVEVAKTVP--DGI 535
            ....||:...::|    |.|.|..|:::      ||.|...:::.|: .|..|:::|.||  .||
Yeast   603 EDITTLSCNHVIP----KENLQTYITNQPELEFTFEKRMSPSLVNNHLFQFFVDLSKAVPKKGGI 663

  Fly   536 VCFFTSYLYLESVVASWYDQGIVDTLLRYKLLFIETQDNAETSYALMNYVKACDCGRGAVLLAVA 600
            |.||.||.||..|:..|.......||...:.:|.|.:|..:   .|..|..:...|||::|||:.
Yeast   664 VAFFPSYQYLAHVIQCWKQNDRFATLNNVRKIFYEAKDGDD---ILSGYSDSVAEGRGSLLLAIV 725

  Fly   601 RGKVSEGVDFDHHYGRAVLMFGIPY--VYTQSRILKARLDYL----------RDQFQIRENDFLT 653
            .||:|||::|.....|||:|.|:|:  :::...|:|.:  :|          .::......:|:.
Yeast   726 GGKLSEGINFQDDLCRAVVMVGLPFPNIFSGELIVKRK--HLAAKIMKSGGTEEEASRATKEFME 788

  Fly   654 FDAMRHAAQCVGRALRGKTDYGIMIFADKRFSRHDKRSRLPKWIQEHLVDSFCNLSTEEAVQLAR 718
            ...|:...|.||||:|...||..:...|.|::|.:.|.:|.:|:|:.:....   :|.:.:...|
Yeast   789 NICMKAVNQSVGRAIRHANDYANIYLLDVRYNRPNFRKKLSRWVQDSINSEH---TTHQVISSTR 850

  Fly   719 RW 720
            ::
Yeast   851 KF 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Xpd	NP_726036.2	rad3	7..717	CDD:273169	175/712 (25%)
		DEXDc2	8..280	CDD:214693	58/234 (25%)
		HBB	270..413	CDD:284245	31/162 (19%)
		HELICc2	542..686	CDD:214694	45/155 (29%)
CHL1	NP_015317.1	PRK08074	<13..>50	CDD:236148
		DEAD-like_helicase_N	36..>60	CDD:421690
		rad3	136..849	CDD:273169	175/712 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1199
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810