Protein Alignment Xpd and BRIP1

DIOPT Version :9

• Sequence 1: NP_726036.2
• Gene: Xpd / 37414
• FlyBaseID: FBgn0261850
• Length: 769
• Species: Drosophila melanogaster
• Sequence 2: XP_011523634.1
• Gene: BRIP1 / 83990
• HGNCID: 20473
• Length: 1269
• Species: Homo sapiens
• Alignment Length: 983
• Identity: 227/983 - (23%)
• Similarity: 376/983 - (38%)
• Gaps: 303/983 - (30%)

  Fly     4 SVDGLLVYFPYEYIYPEQYAYMLELKRSLDAKGHCLLEMPSGTGKTATLLSLIVAY--------- 59
            ::.|:.:||||: .||.|.|.|..:.|.|::|.|||||.|:|:||:..||...:|:
Human     9 TIGGVKIYFPYK-AYPSQLAMMNSILRGLNSKQHCLLESPTGSGKSLALLCSALAWQQSLSGKPA 72

  Fly    60 ---MVEHPE----------------------TVRKLIYCSRTVP--------------------- 78
               :.|..|                      |.|...|.| |.|
Human    73 DEGVSEKAEVQLSCCCACHSKDFTNNDMNQGTSRHFNYPS-TPPSERNGTSSTCQDSPEKTTLAA 136

  Fly    79 ------------------EIEKV-IAELQNLMVYYERHC-------------------------- 98
                              ::||. |..|:......:|||
Human   137 KLSAKKQASIYRDENDDFQVEKKRIRPLETTQQIRKRHCFGTEVHNLDAKVDSGKTVKLNSPLEK 201

  Fly    99 -----PNPPP------------------------------------------------------- 103
                 |..||
Human   202 INSFSPQKPPGHCSRCCCSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRRT 266

  Fly   104 -FTGL---VLSSRKNMCIHPEV-----SKEREGKAVDGK----CYGLTASY-IRERHEMDTETPI 154
             ::|:   :||||.:.|:||||     ..|:..:.:|||    ||.....: |.::|.:.|...:
Human   267 AYSGVPMTILSSRDHTCVHPEVVGNFNRNEKCMELLDGKNGKSCYFYHGVHKISDQHTLQTFQGM 331

  Fly   155 CQYFEGFSLEGKESTLPVGVYSIDDLKEYGRSRNWCPYFLARYAIAHAHIVVYSYHYLLDPKIAQ 219
            |:                 .:.|::|...|:....|||:.||..|..|.|:...|:||||.:|.:
Human   332 CK-----------------AWDIEELVSLGKKLKACPYYTARELIQDADIIFCPYNYLLDAQIRE 379

  Fly   220 VVSKEMSRESCVVFDEAHNIDNVCIDSMSVKINRRTVERSTNALNHLTKLVQDIREEDTNRLNEE 284
            .:...: :|..|:.||||||::...:|.|..:....:..:.:.|:.:..  .:||::|...|...
Human   380 SMDLNL-KEQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVN--NNIRKKDHEPLRAV 441

  Fly   285 YQRMVQGLK---DASVQRDTD---MILANPVLPNDVLTEVVPGNIRNA------DHFLSFLRRFI 337
            ...::..|:   :..|:||.:   .|.:.    |::|..:....|..|      .||.:.|::..
Human   442 CCSLINWLEANAEYLVERDYESACKIWSG----NEMLLTLHKMGITTATFPILQGHFSAVLQKEE 502

  Fly   338 E----YIKTRLRVHHVVQESPAGFLKDISSKI-CIERKPLRFCAERLSSLLRT------LEISDL 391
            :    |.|...|...|:..|....||.:...: .:.|:..||..:...::.:|      ::|||
Human   503 KISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRFADDYKIAIQQTYSWTNQIDISD- 566

  Fly   392 TEYGALTLITHFATLVSTYTKGFTIIIEPFDDKTPTVSNP--ILHFSCLDSSIAMAPVFSRFQTV 454
             :.|.|.|                    |.:.|.......  :|:|.||:.::|.:.:..:.||:
Human   567 -KNGLLVL--------------------PKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTI 610

  Fly   455 VITSGTLSPMDMYPKILDF-------------DPVVMSS----FTMTLARPCLLPMIVS------ 496
            |:||||||||..:...|..             :..:|||    :.:..||...|.:.|.
Human   611 VLTSGTLSPMKSFSSELGVTFTIQLEANHIIKNSQIMSSKFIIYVVACARVSSLKVWVGTIGSGP 675

  Fly   497 KGNDQVTISSKFETREDTAVIRNYGQLLVEVAKTVPDGIVCFFTSYLYLESVVASWYDQGIVDTL 561
            ||.:   :.:.|:..|........|.||:.|.:||..||:||..||..||.:...|...|:...|
Human   676 KGRN---LCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNL 737

  Fly   562 LRYKLLFIETQDNAETS--------YALMNYVKACDCGRGAVLLAVARGKVSEGVDFDHHYGRAV 618
            ...|.:.:|.|...:|:        |..:.|....|   ||:|:||.|||||||:||.....|||
Human   738 ELVKTVIVEPQGGEKTNFDELLQVYYDAIKYKGEKD---GALLVAVCRGKVSEGLDFSDDNARAV 799

  Fly   619 LMFGIPYVYTQSRILKARLDYLRDQFQIR----ENDFLTFDAMRHAAQCVGRALRGKTDYGIMIF 679
            :..|||:...:...::.:..|.....::|    ...:....|.|...|.:||.:|.:.|:|.:|.
Human   800 ITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGRQWYEIQAYRALNQALGRCIRHRNDWGALIL 864

  Fly   680 ADKRFSRHDKR--SRLPKWIQEHLVDSFCNLSTEEAVQLARRWLRRMAQPFTREDQ--LGISLLT 740
            .|.||..:..|  |.|.||:::.:.    :.||.|:.      |..:|: |:::.|  |.:|:..
Human   865 VDDRFRNNPSRYISGLSKWVRQQIQ----HHSTFESA------LESLAE-FSKKHQKVLNVSIKD 918

  Fly   741 LAQLENME 748
            ...:::.|
Human   919 RTNIQDNE 926

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Xpd	NP_726036.2	rad3	7..717	CDD:273169	220/945 (23%)
		DEXDc2	8..280	CDD:214693	93/445 (21%)
		HBB	270..413	CDD:284245	33/165 (20%)
		HELICc2	542..686	CDD:214694	47/155 (30%)
BRIP1	XP_011523634.1	rad3	245..901	CDD:273169	178/717 (25%)
		DEAD_2	248..415	CDD:284209	47/184 (26%)
		Helicase_C_2	700..886	CDD:290046	61/188 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1199
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141017at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820