DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Xpd and brip1

DIOPT Version :9

Sequence 1:	NP_726036.2	Gene:	Xpd / 37414	FlyBaseID:	FBgn0261850	Length:	769	Species:	Drosophila melanogaster
Sequence 2:	NP_001103766.2	Gene:	brip1 / 794038	ZFINID:	ZDB-GENE-081107-11	Length:	1216	Species:	Danio rerio

Alignment Length:	710	Identity:	171/710 - (24%)
Similarity:	289/710 - (40%)	Gaps:	130/710 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 GTGKTATLLSLIVAYMVEHPETVRKLIYCSRTVPEIEKVIAELQNLMVYYERHCPNPPPFTGLVL 109
            |:||                :.:.|:.:.:||..:|.::..||:..:.       :..|.|  :|
Zfish   264 GSGK----------------KKIPKIFFGTRTHKQITQIARELKRTLY-------STVPMT--IL 303

  Fly   110 SSRKNMCIHPEV-----SKEREGKAVDGKCYGLTASYIRERHEMDTETPICQYFEGFSLEGKEST 169
            |||.:.|:||||     ..||..:.::.| .|.:..|....|:|..::.: |:..|..
Zfish   304 SSRDHTCVHPEVVPHANRNERCKEFLEAK-NGRSCRYYHNVHKMRDQSTL-QWVHGLH------- 359

  Fly   170 LPVGVYSIDDLKEYGRSRNWCPYFLARYAIAHAHIVVYSYHYLLDPKIAQVVSKEMS-RESCVVF 233
               ..:.|::|...|.....|.|:.||..:..|.||...|:|||||.|.:  |.|:: :|..||.
Zfish   360 ---QAWDIEELVRLGGKLRSCAYYAARELMQEACIVFCPYNYLLDPLIRE--SMEINLKEQIVVL 419

  Fly   234 DEAHNIDNVCIDSMSVKINRRTVERSTNALNHLTKLVQDIREEDTNR--------LNEEYQRMVQ 290
            ||||||::...:|.|..:|:..:..:.:.::.:  :..:|| .|.:|        |....|....
Zfish   420 DEAHNIEDCARESASFTLNQAQLLLARDEIDGM--VTHNIR-RDQHRPLLAFCCSLTNWVQESCG 481

  Fly   291 GLKDASVQRDTDMILANPVLPNDVLTEVVPGNIR----NADHFLSFLRRFIEYIKTRLRVHHVVQ 351
            ||::...:....:.....||          |..|    .||.|....:.....::...||..|..
Zfish   482 GLEEREYESSCKVWTGVEVL----------GIFRGLGITADTFPLLQKNLAAVLEKEERVGLVNG 536

  Fly   352 ESPAGFLKDISSKICIERKPLRFCAERLSSLLRTLEISDLTEYGALTLITHFATLVSTY------ 410
            ......:..|||.          ....|.||...||.  |..........:...|..:|
Zfish   537 REETVQVPTISSN----------TQSMLKSLFMVLEF--LFRQNCRFADDYRVALQQSYMWTTQQ 589

  Fly   411 ----TKGFTIIIEPFDDKTPTVSNPILH---FSCLDSSIAMAPVFSRFQTVVITSGTLSPMDMYP 468
                .:||  ...|...:....:..::|   |.||:.::|.:.:.|..:::|:||||||||..:.
Zfish   590 DLPDAQGF--FARPHRRRQSNRTKTLVHTLSFWCLNPAVAFSDLSSTVRSIVLTSGTLSPMGSFS 652

  Fly   469 KILDFDPVVMSSFTMTLARPCLLPMIVSKGNDQVTISSKFETREDTAVIRNYGQLLVEVAKTVPD 533
            ..|.....:.......:.:..:....:..|.....:.:.|:..|..|.....|.||::|..||..
Zfish   653 SELGIKFSIQLEANHVINKSQVWVGTIGAGPQGRKLCATFQHAETFAFQDEVGALLLKVCHTVSR 717

  Fly   534 GIVCFFTSYLYLESVVASWYDQGIVDTLLRYKLLFIETQDNAETSY--ALMNYVKAC-------D 589
            |::||..||..|:.:...|.:.|:.|.|...|.:..|.:...:..:  .|..|.:|.       :
Zfish   718 GVLCFLPSYKMLDKLRDRWTNTGLWDKLEECKTVITEPRGGGKGDFDELLQTYYEAIRGTAAKGE 782

  Fly   590 CGRGAVLLAVARGKVSEGVDFDHHYGRAVLMFGIPYVYTQSRILKARLDYLRDQFQIREND---- 650
            ...||:|:||.|||||||:||.....|||:..|||:         ..:..|:.:.:::.||
Zfish   783 KRDGALLVAVCRGKVSEGLDFTDDNARAVVTIGIPF---------PNIKDLQVELKMKYNDKHAK 838

  Fly   651 ---------FLTFDAMRHAAQCVGRALRGKTDYGIMIFADKRFSRHDKR--SRLPKWIQE 699
                     :....|.|...|.:||.:|.:.|:|.:|..|.||..:..:  :.|.||:::
Zfish   839 SRGLLPGGRWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRTNPNKYITGLSKWVRQ 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Xpd	NP_726036.2	rad3	7..717	CDD:273169	171/710 (24%)
		DEXDc2	8..280	CDD:214693	63/240 (26%)
		HBB	270..413	CDD:284245	29/164 (18%)
		HELICc2	542..686	CDD:214694	46/165 (28%)
brip1	NP_001103766.2	PolC	<23..>73	CDD:331024
brip1	NP_001103766.2	HBB	272..913	CDD:331768	168/686 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141017at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920