DRSC/TRiP Functional Genomics Resources

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Protein Alignment Xpd and RTEL1

DIOPT Version :9

Sequence 1:NP_726036.2 Gene:Xpd / 37414 FlyBaseID:FBgn0261850 Length:769 Species:Drosophila melanogaster
Sequence 2:NP_001269938.1 Gene:RTEL1 / 51750 HGNCID:15888 Length:1300 Species:Homo sapiens


Alignment Length:851 Identity:206/851 - (24%)
Similarity:341/851 - (40%) Gaps:213/851 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 KLSVDGLLVYFPYEYIYPEQYAYMLELKRSLDAKGHCLLEMPSGTGKTATLLSLIVAYMVEH--- 63
            |:.::|:.|.||:: .|..|..||.::...|..|.:.:||.|:|||||..||...:|:. ||   
Human     3 KIVLNGVTVDFPFQ-PYKCQQEYMTKVLECLQQKVNGILESPTGTGKTLCLLCTTLAWR-EHLRD 65

  Fly    64 ----------------PE---------------------TVRKLIYCSRTVPEIEKVIAELQNLM 91
                            |:                     .:.|:||.|||..::.:||.||:|..
Human    66 GISARKIAERAQGELFPDRALSSWGNAAAAAGDPIACYTDIPKIIYASRTHSQLTQVINELRNTS 130

  Fly    92 VYYERHCPNPPPFTGLVLSSRKNMCIHPEVSKEREGKAVDGKCYGLTASYIRERHEMDTETPICQ 156
             |..:.|         ||.||:.:||||||.|:.........|....||            ..|.
Human   131 -YRPKVC---------VLGSREQLCIHPEVKKQESNHLQIHLCRKKVAS------------RSCH 173

  Fly   157 YFEGFSLEGKESTLPVGVYSIDDLKEYGRSRNWCPYFLARYAIAHAHIVVYSYHYLLDPKIAQVV 221
            ::.....:..|..|...:..|:||.:.|.....|||:|:|.....|.|:...|:||||.|..:..
Human   174 FYNNVEEKSLEQELASPILDIEDLVKSGSKHRVCPYYLSRNLKQQADIIFMPYNYLLDAKSRRAH 238

  Fly   222 SKEMSRESCVVFDEAHNIDNVCIDSMSVKINRRTVERSTNALNHL----TKLVQ----------- 271
            :.:: :.:.|:||||||::.:|.:|.|..:....:....:.::.:    ||..|           
Human   239 NIDL-KGTVVIFDEAHNVEKMCEESASFDLTPHDLASGLDVIDQVLEEQTKAAQQGEPHPEFSAD 302

  Fly   272 ------DIREEDTNRLNEEYQRMVQGLKDASVQRDTDMILANPVLPNDVLTEVVPGN-------- 322
                  ::..||..:|.....|: :|..|| |:           ||.|......||:        
Human   303 SPSPGLNMELEDIAKLKMILLRL-EGAIDA-VE-----------LPGDDSGVTKPGSYIFELFAE 354

  Fly   323 ----IRNADHFLSFLRRFIEYIKTRLRVHHVVQESPAGFLKDISSKICIERKPLRFCAERLSSLL 383
                .:.....|..|.:.|:::..|..|.    .:.||.                   ::|:.::
Human   355 AQITFQTKGCILDSLDQIIQHLAGRAGVF----TNTAGL-------------------QKLADII 396

  Fly   384 RTLEISDLTE--------YGALTLITHFATLVSTYTKGFTIIIEP----------FDDKTPTVS- 429
            :.:...|.:|        .|||              :.:.:.|.|          .|..:.|.: 
Human   397 QIVFSVDPSEGSPGSPAGLGAL--------------QSYKVHIHPDAGHRRTAQRSDAWSTTAAR 447

  Fly   430 --NPILHFSCLDSSIAMAPVFSR-FQTVVITSGTLSPMDMYPKILDFDPVVMSSFTMTLARP--- 488
              ..:|.:.|.....:|..:..: .:::::|||||:|              :|||.:.:..|   
Human   448 KRGKVLSYWCFSPGHSMHELVRQGVRSLILTSGTLAP--------------VSSFALEMQIPFPV 498

  Fly   489 CL-LPMIVSK----------GNDQVTISSKFETREDTAVIRNYGQLLVEVAKTVPDGIVCFFTSY 542
            || .|.|:.|          |.|...:||.|:.|.....:.:.|:.|..:|:.||.|::.||.||
Human   499 CLENPHIIDKHQIWVGVVPRGPDGAQLSSAFDRRFSEECLSSLGKALGNIARVVPYGLLIFFPSY 563

  Fly   543 LYLESVVASWYDQGIVDTLLRYKLLFIETQDNAETSYALMNYVK--ACDCGRGAVLLAVARGKVS 605
            ..:|..:..|..:.:...:...|.||:|.:.....|..:..|..  |.....||..|||.|||.|
Human   564 PVMEKSLEFWRARDLARKMEALKPLFVEPRSKGSFSETISAYYARVAAPGSTGATFLAVCRGKAS 628

  Fly   606 EGVDFDHHYGRAVLMFGIPYVYTQSRILKARLDYLRD---------QFQIRENDFLTFDAMRHAA 661
            ||:||....||.|::.|:||.......:..::.:|.:         || :...::....|.|...
Human   629 EGLDFSDTNGRGVIVTGLPYPPRMDPRVVLKMQFLDEMKGQGGAGGQF-LSGQEWYRQQASRAVN 692

  Fly   662 QCVGRALRGKTDYGIMIFADKRFSRHDKRSRLPKWIQEH--LVDSFCNLSTEEAVQLARRWLRRM 724
            |.:||.:|.:.|||.:...|.||:..|.|::||.|::.|  :.|:|.:: ..:..|..|...|.|
Human   693 QAIGRVIRHRQDYGAVFLCDHRFAFADARAQLPSWVRPHVRVYDNFGHV-IRDVAQFFRVAERTM 756

  Fly   725 AQPFTR 730
            ..|..|
Human   757 PAPAPR 762

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
XpdNP_726036.2 rad3 7..717 CDD:273169 200/831 (24%)
DEXDc2 8..280 CDD:214693 85/332 (26%)
HBB 270..413 CDD:284245 27/179 (15%)
HELICc2 542..686 CDD:214694 44/154 (29%)
RTEL1NP_001269938.1 rad3 10..743 CDD:273169 198/823 (24%)
P-loop_NTPase 15..>60 CDD:304359 17/45 (38%)
DEAD_2 111..272 CDD:284209 55/183 (30%)
Nuclear localization signal. /evidence=ECO:0000255|HAMAP-Rule:MF_03065 151..167 2/15 (13%)
DEAH box 250..253 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 287..306 3/18 (17%)
Helicase_C_2 545..731 CDD:290046 57/186 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 757..786 2/6 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 839..877
Nuclear localization signal. /evidence=ECO:0000255|HAMAP-Rule:MF_03065 871..877
HN_RTEL1 877..976 CDD:259826
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 979..1005
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1017..1054
HN_RTEL1 1052..1138 CDD:259826
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1132..1151
PIP-box 1178..1185
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1199
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D141017at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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