DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Xpd and rtel1

DIOPT Version :9

Sequence 1:	NP_726036.2	Gene:	Xpd / 37414	FlyBaseID:	FBgn0261850	Length:	769	Species:	Drosophila melanogaster
Sequence 2:	NP_001013328.2	Gene:	rtel1 / 503732	ZFINID:	ZDB-GENE-050306-11	Length:	1177	Species:	Danio rerio

Alignment Length:	883	Identity:	201/883 - (22%)
Similarity:	354/883 - (40%)	Gaps:	189/883 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LSVDGLLVYFPYEYIYPEQYAYMLELKRSLDAKGHCLLEMPSGTGKTATLLSLIVAYMVEHPETV 67
            :.:.|:.|.||:. .||.|..||.::...|..|.:.:||.|:|||||..||...:|:.....:|:
Zfish     4 IKLKGINVDFPFT-PYPCQEDYMSKVIECLQKKVNGVLESPTGTGKTLCLLCSTLAWRDHFKDTI 67

  Fly    68 R---------------------------------------KLIYCSRTVPEIEKVIAELQNLMVY 93
            .                                       |:||.|||..::.:|:.||:|.. |
Zfish    68 SARKITERMGGAELFADRPMSSWGTAATDGDTPTYYTDIPKIIYASRTHSQLTQVVNELKNTS-Y 131

  Fly    94 YERHCPNPPPFTGLVLSSRKNMCIHPEVSKEREGKAVDGKCYGLTASYIRERHEMDTETPICQYF 158
            ..:.|         ||.||:.:||:.||.:..........|          |.::.:.:  |.::
Zfish   132 RPKIC---------VLGSREQLCINQEVMRHESNHIKVHMC----------RAKVSSRS--CIFY 175

  Fly   159 EGFSLEGKESTLPVGVYSIDDLKEYGRSRNWCPYFLARYAIAHAHIVVYSYHYLLDPKIAQVVSK 223
            .....:..:..:...:..::||.:.|:.:..|||:|:|....||.::...|:||||||..:..:.
Zfish   176 NNVDEKSTDKEIVNSILDVEDLVKTGKKQRVCPYYLSRSLKQHADVIFMPYNYLLDPKSRRAHNI 240

  Fly   224 EMSRESCVVFDEAHNIDNVCIDSMSVKINRRTVERSTNALNHLTK-LVQDIREEDTNRLNEEY-- 285
            |: :.:.|:||||||::.:|.:|.|..:....:..:..|::.|.: ...||.:.|:   .|::
Zfish   241 EL-KGAVVIFDEAHNVEKMCEESTSFDLTPHDLISAIEAVDRLLREQASDISKADS---AEDFNV 301

  Fly   286 QRMVQGLK-DASVQRDTDMILANPVLPNDVLTEV----VPGNIRNADHFLSFLRRFIEY--IKTR 343
            :.:..||| |.:.......||.      |:.|.:    :|.|.:......||:....|.  :.::
Zfish   302 ESLNSGLKMDITTIAKVKQILM------DLETAINDFEMPANNQGITKPGSFIFELFEMANVNSK 360

  Fly   344 LRVHHV-VQESPAGFLKDISSKICIERKPLRFCAERLSSLLRTLEISDLTEYGALTLITHFA--- 404
            .:...| ..|...|:|                 |.|....|.|..:..:.:...|..:...|
Zfish   361 TKTETVEAMEQITGYL-----------------AGRPGVFLNTSGLQKVADIIQLVFVAEPAEGS 408

  Fly   405 --TLVSTYTKGFTIIIEP----FDDKTPT---------VSNPILHFSCLDSSIAMAPVF-SRFQT 453
              :......|.|.:.|.|    |..|..|         ....:|.:.|.....:|..:. ...:.
Zfish   409 KKSQTGNSLKEFKVHIHPDNSNFKKKQITDVWASSSTKKQGNVLSYWCFSPGFSMQELLRQEVRC 473

  Fly   454 VVITSGTLSPMDMY--------------PKILDFDPVVMSSFTMTLARPCLLPMIVSKGNDQVTI 504
            :::|||||||:..:              |.::..|.:.:|              |:.||.|.|.:
Zfish   474 IILTSGTLSPLSSFTCEMQIPFPVSLENPHVIQRDQIFVS--------------IIEKGPDGVQL 524

  Fly   505 SSKFETREDTAVIRNYGQLLVEVAKTVPDGIVCFFTSYLYLESVVASWYDQGIVDTLLRYKLLFI 569
            |:.|:.|.....:.:.|..||.:::.||.|::.||.||..::..:..|..:|..|.:...|.:|:
Zfish   525 STAFDRRFVPENMSSMGNTLVNLSRVVPHGLLVFFPSYPVMDKTLEFWRAKGHADRIENVKPMFV 589

  Fly   570 ETQDNAETSYALMNYVKACD--CGRGAVLLAVARGKVSEGVDFDHHYGRAVLMFGIPYVYTQSRI 632
            |.:.....:..:..|....|  ...|....||.|||.|||:||...|||.|::.|:|:.......
Zfish   590 EPRGKGTFTEVIDGYYGKVDDPNSSGGSFFAVCRGKASEGLDFADTYGRGVVITGLPFPPRMDPR 654

  Fly   633 LKARLDYLRDQFQ--------IRENDFLTFDAMRHAAQCVGRALRGKTDYGIMIFADKRFSRHDK 689
            :..::.||.:..:        :...::....|.|...|.:||.:|.:.|||.:...|.||...|.
Zfish   655 VVLKMQYLDEMCRNKISGVKYLTGQEWYRQQASRAVNQAIGRVIRHREDYGAIFLCDHRFKSADA 719

  Fly   690 RSRLPKWIQEH--LVDSFCNLSTEEAVQLARRWLRRMAQPF-------------TREDQLGISLL 739
            |::||.|::.:  :.|.|..: ..:..|..|...:....|.             ||....|.|.|
Zfish   720 RNQLPSWVRPYVKIYDGFGTM-VRDVAQFFRTAQKTRPVPVKKGKAEGHENQADTRLLNTGSSCL 783

  Fly   740 TL---------------AQLENMEQEKLE-RQAQGKQG 761
            |.               |.:.::::.||: .:..|::|
Zfish   784 TKSVWPSDIYQKAKTLDAHVPSLKRRKLDSEEHSGREG 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Xpd	NP_726036.2	rad3	7..717	CDD:273169	188/804 (23%)
		DEXDc2	8..280	CDD:214693	78/311 (25%)
		HBB	270..413	CDD:284245	27/157 (17%)
		HELICc2	542..686	CDD:214694	40/153 (26%)
rtel1	NP_001013328.2	rad3	13..742	CDD:273169	185/793 (23%)
		DEAD_2	111..272	CDD:284209	49/183 (27%)
		Nuclear localization signal. /evidence=ECO:0000255\|HAMAP-Rule:MF_03065	151..167		2/25 (8%)
		DEAH box	250..253		2/2 (100%)
		Helicase_C_2	544..730	CDD:290046	53/185 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	847..869
		Nuclear localization signal. /evidence=ECO:0000255\|HAMAP-Rule:MF_03065	883..889
		HN_RTEL1	889..987	CDD:259826
		HN_RTEL1	1041..1144	CDD:259826
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1199
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141017at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820