DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Xpd and ercc2

DIOPT Version :9

Sequence 1:	NP_726036.2	Gene:	Xpd / 37414	FlyBaseID:	FBgn0261850	Length:	769	Species:	Drosophila melanogaster
Sequence 2:	NP_957220.2	Gene:	ercc2 / 393900	ZFINID:	ZDB-GENE-040426-997	Length:	760	Species:	Danio rerio

Alignment Length:	757	Identity:	516/757 - (68%)
Similarity:	641/757 - (84%)	Gaps:	2/757 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKLSVDGLLVYFPYEYIYPEQYAYMLELKRSLDAKGHCLLEMPSGTGKTATLLSLIVAYMVEHPE 65
            |||::|||||||||:|||||||:|||||||:||||||.:||||||||||.:||||||||...:|.
Zfish     1 MKLNIDGLLVYFPYDYIYPEQYSYMLELKRTLDAKGHGVLEMPSGTGKTISLLSLIVAYQKTYPL 65

  Fly    66 TVRKLIYCSRTVPEIEKVIAELQNLMVYYERHCPNPPPFTGLVLSSRKNMCIHPEVSKEREGKAV 130
            .|.||:||||||||||||:.||:.||.||.:.......|..|.||||||:|||||||..|.||.|
Zfish    66 EVTKLVYCSRTVPEIEKVVEELRKLMDYYSKQTGVKNDFLALALSSRKNLCIHPEVSSLRFGKEV 130

  Fly   131 DGKCYGLTASYIRERHEMDTETPICQYFEGFSLEGKESTLPVGVYSIDDLKEYGRSRNWCPYFLA 195
            ||||:.|||||||.:|:.:...|:||::|.|...|::..:|.|:|::||||::||.:.|||||||
Zfish   131 DGKCHSLTASYIRAQHQSNPNQPVCQFYEEFDNVGRQVPIPPGIYNLDDLKDFGRRKGWCPYFLA 195

  Fly   196 RYAIAHAHIVVYSYHYLLDPKIAQVVSKEMSRESCVVFDEAHNIDNVCIDSMSVKINRRTVERST 260
            |||:.||:|||||||||||||||.:||||::::|.|||||||||||||||||||.|.|||::|..
Zfish   196 RYALLHANIVVYSYHYLLDPKIADLVSKELAKKSVVVFDEAHNIDNVCIDSMSVNITRRTLDRCQ 260

  Fly   261 NALNHLTKLVQDIREEDTNRLNEEYQRMVQGLKDASVQRDTDMILANPVLPNDVLTEVVPGNIRN 325
            ..:..|...:..|:|.|..:|.|||:|:|:|||:|:|.|:||:.|:|||||:::|.|.|||:||.
Zfish   261 TNVETLQNTISRIKETDAAKLREEYRRLVEGLKEANVARETDIYLSNPVLPDEILQEAVPGSIRT 325

  Fly   326 ADHFLSFLRRFIEYIKTRLRVHHVVQESPAGFLKDISSKICIERKPLRFCAERLSSLLRTLEISD 390
            |:||:.|::||:||:|.|||:|||||||...|||||..|:||:|||||||||||.||||||||:|
Zfish   326 AEHFVGFMKRFLEYLKARLRIHHVVQESAPQFLKDIFEKVCIDRKPLRFCAERLRSLLRTLEIAD 390

  Fly   391 LTEYGALTLITHFATLVSTYTKGFTIIIEPFDDKTPTVSNPILHFSCLDSSIAMAPVFSRFQTVV 455
            :.::..:|||:|||||||||:||||||||||:|||||::||:|||||:|.|||:.|||.|||||:
Zfish   391 IADFSPITLISHFATLVSTYSKGFTIIIEPFEDKTPTIANPVLHFSCMDPSIAIKPVFGRFQTVI 455

  Fly   456 ITSGTLSPMDMYPKILDFDPVVMSSFTMTLARPCLLPMIVSKGNDQVTISSKFETREDTAVIRNY 520
            ||||||||:|:||:||||.||.|:||||||||.||.|:||.:|||||.::||||||||.||||||
Zfish   456 ITSGTLSPLDIYPRILDFRPVTMASFTMTLARTCLCPLIVGRGNDQVAMTSKFETREDFAVIRNY 520

  Fly   521 GQLLVEVAKTVPDGIVCFFTSYLYLESVVASWYDQGIVDTLLRYKLLFIETQDNAETSYALMNYV 585
            |.||:|::..||||||.|||||:|:|::|||||:|||::.:.|.||:||||||.||||.||..|.
Zfish   521 GNLLLEMSAIVPDGIVAFFTSYMYMENIVASWYEQGILENIQRNKLIFIETQDAAETSMALEKYQ 585

  Fly   586 KACDCGRGAVLLAVARGKVSEGVDFDHHYGRAVLMFGIPYVYTQSRILKARLDYLRDQFQIREND 650
            :||:.||||:||:|||||||||:||.||:||||:|||:||||||||||||||:||||||||||||
Zfish   586 EACENGRGAILLSVARGKVSEGIDFVHHFGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIREND 650

  Fly   651 FLTFDAMRHAAQCVGRALRGKTDYGIMIFADKRFSRHDKRSRLPKWIQEHLVDSFCNLSTEEAVQ 715
            |||||||||||||||||:|||||||:|||||||::|.|||.:||:||||||.|...||:.:|.||
Zfish   651 FLTFDAMRHAAQCVGRAIRGKTDYGLMIFADKRYARADKRGKLPRWIQEHLTDGSLNLTIDETVQ 715

  Fly   716 LARRWLRRMAQPFTREDQLGISLLTLAQLENMEQEKLERQAQ 757
            |::.:||:|||||.||||||:|||||.||::  ::.|::.||
Zfish   716 LSKHFLRQMAQPFRREDQLGLSLLTLEQLQS--EDMLQKIAQ 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Xpd	NP_726036.2	rad3	7..717	CDD:273169	488/709 (69%)
		DEXDc2	8..280	CDD:214693	173/271 (64%)
		HBB	270..413	CDD:284245	89/142 (63%)
		HELICc2	542..686	CDD:214694	112/143 (78%)
ercc2	NP_957220.2	rad3	7..708	CDD:273169	483/700 (69%)
		DEXDc2	8..278	CDD:214693	172/269 (64%)
		HBB	270..413	CDD:284245	89/142 (63%)
		HELICc2	542..686	CDD:214694	112/143 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593537
Domainoid	1	1.000	289	1.000	Domainoid score	I1528
eggNOG	1	0.900	-	-		E1_COG1199
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H344
Inparanoid	1	1.050	1086	1.000	Inparanoid score	I234
OMA	1	1.010	-	-		QHG62382
OrthoDB	1	1.010	-	-		D141017at33208
OrthoFinder	1	1.000	-	-		FOG0005257
OrthoInspector	1	1.000	-	-		oto39562
orthoMCL	1	0.900	-	-		OOG6_101742
Panther	1	1.100	-	-	LDO	PTHR11472
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1054
SonicParanoid	1	1.000	-	-		X3778
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800