DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Xpd and Rtel1

DIOPT Version :9

Sequence 1:	NP_726036.2	Gene:	Xpd / 37414	FlyBaseID:	FBgn0261850	Length:	769	Species:	Drosophila melanogaster
Sequence 2:	XP_006500696.1	Gene:	Rtel1 / 269400	MGIID:	2139369	Length:	1266	Species:	Mus musculus

Alignment Length:	830	Identity:	205/830 - (24%)
Similarity:	351/830 - (42%)	Gaps:	140/830 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KLSVDGLLVYFPYEYIYPEQYAYMLELKRSLDAKGHCLLEMPSGTGKTATLLSLIVAYM------ 60
            ::.::|:.|.||:: .||.|..||.::...|..|.:.:||.|:|||||..||...:|:.
Mouse     3 RVVLNGVTVDFPFQ-PYPCQQEYMTKVLECLQKKVNGILESPTGTGKTLCLLCSTLAWQQHLRDA 66

  Fly    61 ---------------------------------VEHPETVRKLIYCSRTVPEIEKVIAELQNLMV 92
                                             :|....:.|:||.|||..::.:||.||:| ..
Mouse    67 VSSLKIAERVQGELFASRTLSSWGSAAAASGDSIECYTDIPKIIYASRTHSQLTQVIRELRN-TA 130

  Fly    93 YYERHCPNPPPFTGLVLSSRKNMCIHPEVSKEREGKAVDGKCYGLTASYIRERHEMDTETPICQY 157
            |..:.|         ||.||:.:||||||.|:.........|....||            ..|.:
Mouse   131 YRPKVC---------VLGSREQLCIHPEVKKQESNHMQISLCRKKVAS------------RSCHF 174

  Fly   158 FEGFSLEGKESTLPVGVYSIDDLKEYGRSRNWCPYFLARYAIAHAHIVVYSYHYLLDPKIAQVVS 222
            :.....:..|..|...:..|:||.:.|..:..|||:|:|.....|.|:...|:||||.|..:..|
Mouse   175 YNNVEAKFLEQDLATPILDIEDLVKNGSKQKMCPYYLSRNMKQQADIIFMPYNYLLDAKSRKAHS 239

  Fly   223 KEMSRESCVVFDEAHNIDNVCIDSMSVKINRRTVERSTNALNHLTKLVQDIREEDTNRLNEEY-- 285
            .:: :.:.|:||||||::.:|.:|.|..:..|.|......:|.:  |.:..|......|.:|:
Mouse   240 IDL-KGTVVIFDEAHNVEKICEESASFDLTPRDVASGLEIINQV--LEEQARVTQQGELQQEFIV 301

  Fly   286 ----QRMVQGLKDASVQRDTDMILANPVLPNDVLTEVVPGNIRNADHFLSFLRRFIEYIKTRLRV 346
                ..:...|:|.:..:   |||..  |...:....:||:.|......|::.......:...:.
Mouse   302 DTSSSGLNMELEDIAKLK---MILLR--LEEAIDAVQLPGDDRGVTKPGSYIFELFAEAQITFQT 361

  Fly   347 HHVVQESPAGFLKDISSKICIERKPLRFCAERLSSLLRTLEISDLTEYGALTL----ITHFATLV 407
            ...:.||....::.::.:..:.......  ::|..:::.:...|..|....:|    |:|
Mouse   362 KGCILESLDQIIQHLAGRTGVFTNTAGL--QKLMDIIQIVFSVDPPEGSPGSLVGLGISH----- 419

  Fly   408 STYTKGFTIIIEP----------FDDKTPTVS---NPILHFSCLDSSIAMAP-VFSRFQTVVITS 458
                 .:.:.|.|          .|..:.|.|   ..:|.:.|...|.:|.. |....:|:::||
Mouse   420 -----SYKVHIHPETSHRRAAKRSDAWSTTASRKQGKVLSYWCFSPSQSMRELVCQGVRTLILTS 479

  Fly   459 GTLSPMDMYPKILDFDPVVMSSFTMTLARPCLLPM------IVSKGNDQVTISSKFETREDTAVI 517
            |||:|:.      .|...:...|.:.|..|.::..      ||.:|.|.|.:||.::.|.....:
Mouse   480 GTLAPLS------SFALEMQIPFPVCLENPHIIDKNQLWVGIVPRGPDGVQLSSAYDKRFSEECL 538

  Fly   518 RNYGQLLVEVAKTVPDGIVCFFTSYLYLESVVASWYDQGIVDTLLRYKLLFIETQDNAETSYALM 582
            .:.|:.|..:|:.||.|::.||.||..:|..:..|..||:...:...|.||:|.::....|..:.
Mouse   539 SSLGKALSNIARVVPHGLLVFFPSYPVMEKSLEFWQVQGLARKVEALKPLFVEPRNKGSFSEVID 603

  Fly   583 NYVK--ACDCGRGAVLLAVARGKVSEGVDFDHHYGRAVLMFGIPYVYTQSRILKARLDYLRDQFQ 645
            .|.:  |.....||..|||.|||.|||:||....||.|::.|:||.......:..::.:| |:.:
Mouse   604 AYYQQVASPASNGATFLAVCRGKASEGLDFSDMNGRGVIVTGLPYPPRMDPRVVLKMQFL-DEMR 667

  Fly   646 IRE---------NDFLTFDAMRHAAQCVGRALRGKTDYGIMIFADKRFSRHDKRSRLPKWIQEHL 701
            .|.         .::....|.|...|.:||.:|.:.|||.:...|.||:..|.|::||.|::.:|
Mouse   668 GRSGVGGQCLSGQEWYQQQASRAVNQAIGRVIRHRHDYGAIFLCDHRFAYADARAQLPSWVRPYL 732

  Fly   702 --VDSFCNLSTEEAVQLARRWLRRMAQPFTR-------EDQLGISLLTLA 742
              .|:|.:: ..:..|..|...:.|..|..:       |.::.:...||:
Mouse   733 KVYDNFGHV-IRDVAQFFRVAQKTMPLPVPQAVTSSVSEGEIALKDATLS 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Xpd	NP_726036.2	rad3	7..717	CDD:273169	199/791 (25%)
		DEXDc2	8..280	CDD:214693	85/310 (27%)
		HBB	270..413	CDD:284245	21/152 (14%)
		HELICc2	542..686	CDD:214694	46/154 (30%)
Rtel1	XP_006500696.1	rad3	10..743	CDD:273169	197/783 (25%)
		HN_RTEL1	877..976	CDD:259826
		HN_RTEL1	1038..1126	CDD:259826
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1199
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810