DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Xpd and rad15

DIOPT Version :9

Sequence 1:	NP_726036.2	Gene:	Xpd / 37414	FlyBaseID:	FBgn0261850	Length:	769	Species:	Drosophila melanogaster
Sequence 2:	NP_593025.1	Gene:	rad15 / 2542203	PomBaseID:	SPAC1D4.12	Length:	772	Species:	Schizosaccharomyces pombe

Alignment Length:	758	Identity:	422/758 - (55%)
Similarity:	570/758 - (75%)	Gaps:	5/758 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKLSVDGLLVYFPYEYIYPEQYAYMLELKRSLDAKGHCLLEMPSGTGKTATLLSLIVAYMVEHPE 65
            ||..:|.|.:.|||..||||||.||.:||.||||.|..|||||||||||.:||||||:|...:||
pombe     1 MKFYIDDLPILFPYPRIYPEQYQYMCDLKHSLDAGGIALLEMPSGTGKTISLLSLIVSYQQHYPE 65

  Fly    66 TVRKLIYCSRTVPEIEKVIAELQNLMVYYERHCPNPPPFTGLVLSSRKNMCIHPEVSKEREGKAV 130
            . |||||||||:.||:|.:|||:.||.|.........||.||.|:||||:|:||.|.:|:.|..|
pombe    66 H-RKLIYCSRTMSEIDKALAELKRLMAYRTSQLGYEEPFLGLGLTSRKNLCLHPSVRREKNGNVV 129

  Fly   131 DGKCYGLTASYIRERHEMDTETPICQYFEGFSLEGKE--STLPVGVYSIDDLKEYGRSRNWCPYF 193
            |.:|..|||.::||:.....:.|.|::.:  :||..|  |.:..||:::||:.|||.....||||
pombe   130 DARCRSLTAGFVREQRLAGMDVPTCEFHD--NLEDLEPHSLISNGVWTLDDITEYGEKTTRCPYF 192

  Fly   194 LARYAIAHAHIVVYSYHYLLDPKIAQVVSKEMSRESCVVFDEAHNIDNVCIDSMSVKINRRTVER 258
            ..|..:...::::||||||||||||:.||:|:|::..||||||||||||||:|:|:.:...::.:
pombe   193 TVRRMLPFCNVIIYSYHYLLDPKIAERVSRELSKDCIVVFDEAHNIDNVCIESLSIDLTESSLRK 257

  Fly   259 STNALNHLTKLVQDIREEDTNRLNEEYQRMVQGLKDASVQRDTDMILANPVLPNDVLTEVVPGNI 323
            ::.::..|.:.|.::::.|:.:|.:|||::|:||:||:...|.|..:||||||.|||.|.|||||
pombe   258 ASKSILSLEQKVNEVKQSDSKKLQDEYQKLVRGLQDANAANDEDQFMANPVLPEDVLKEAVPGNI 322

  Fly   324 RNADHFLSFLRRFIEYIKTRLRVHHVVQESPAGFLKDISSKICIERKPLRFCAERLSSLLRTLEI 388
            |.|:||::||:||:||:|||::|.||:.|:|..||:.:.....|::||||||||||:||:|.|:|
pombe   323 RRAEHFIAFLKRFVEYLKTRMKVLHVIAETPTSFLQHVKDITFIDKKPLRFCAERLTSLVRALQI 387

  Fly   389 SDLTEYGALTLITHFATLVSTYTKGFTIIIEPFDDKTPTVSNPILHFSCLDSSIAMAPVFSRFQT 453
            |.:.::.:|..:..|||||:||.:||.:|:|||:.:..||.||||.|||||:|||:.|||.||::
pombe   388 SLVEDFHSLQQVVAFATLVATYERGFILILEPFETENATVPNPILRFSCLDASIAIKPVFERFRS 452

  Fly   454 VVITSGTLSPMDMYPKILDFDPVVMSSFTMTLARPCLLPMIVSKGNDQVTISSKFETREDTAVIR 518
            |:||||||||:|||||:|.|:.|:..|:.|:|||.|.|||:|::|:|||.||||||.|.|.:|:|
pombe   453 VIITSGTLSPLDMYPKMLQFNTVMQESYGMSLARNCFLPMVVTRGSDQVAISSKFEARNDPSVVR 517

  Fly   519 NYGQLLVEVAKTVPDGIVCFFTSYLYLESVVASWYDQGIVDTLLRYKLLFIETQDNAETSYALMN 583
            |||.:|||.:|..|||:|.||.|||||||:|:||...||:|.:.:|||:.:||.|..||:.||..
pombe   518 NYGNILVEFSKITPDGLVAFFPSYLYLESIVSSWQSMGILDEVWKYKLILVETPDPHETTLALET 582

  Fly   584 YVKACDCGRGAVLLAVARGKVSEGVDFDHHYGRAVLMFGIPYVYTQSRILKARLDYLRDQFQIRE 648
            |..||..|||||||:||||||||||||||||||||:||||||.||:||:|||||::|||.:||||
pombe   583 YRAACSNGRGAVLLSVARGKVSEGVDFDHHYGRAVIMFGIPYQYTESRVLKARLEFLRDTYQIRE 647

  Fly   649 NDFLTFDAMRHAAQCVGRALRGKTDYGIMIFADKRFSRHDKRSRLPKWIQEHLVDSFCNLSTEEA 713
            .||||||||||||||:||.||||.|:|||:.||||:.|.|||::||||||:::.:...||||:.:
pombe   648 ADFLTFDAMRHAAQCLGRVLRGKDDHGIMVLADKRYGRSDKRTKLPKWIQQYITEGATNLSTDMS 712

  Fly   714 VQLARRWLRRMAQPFTREDQLGISLLTLAQLENMEQEKLERQA 756
            :.||:::||.||||||..||.|||..:|..|...:::.|:..|
pombe   713 LALAKKFLRTMAQPFTASDQEGISWWSLDDLLIHQKKALKSAA 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Xpd	NP_726036.2	rad3	7..717	CDD:273169	400/711 (56%)
		DEXDc2	8..280	CDD:214693	133/273 (49%)
		HBB	270..413	CDD:284245	73/142 (51%)
		HELICc2	542..686	CDD:214694	102/143 (71%)
rad15	NP_593025.1	rad3	7..707	CDD:273169	396/702 (56%)
		DEXDc2	8..279	CDD:214693	133/273 (49%)
		HBB	268..412	CDD:284245	73/143 (51%)
		HELICc2	541..685	CDD:214694	102/143 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	262	1.000	Domainoid score	I365
eggNOG	1	0.900	-	-		E1_COG1199
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H344
Inparanoid	1	1.050	878	1.000	Inparanoid score	I52
OMA	1	1.010	-	-		QHG62382
OrthoFinder	1	1.000	-	-		FOG0005257
OrthoInspector	1	1.000	-	-		oto100979
orthoMCL	1	0.900	-	-		OOG6_101742
Panther	1	1.100	-	-	LDO	PTHR11472
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1054
SonicParanoid	1	1.000	-	-		X3778
TreeFam	1	0.960	-	-
	14	13.860