DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Xpd and Brip1

DIOPT Version :9

Sequence 1:	NP_726036.2	Gene:	Xpd / 37414	FlyBaseID:	FBgn0261850	Length:	769	Species:	Drosophila melanogaster
Sequence 2:	NP_840094.1	Gene:	Brip1 / 237911	MGIID:	2442836	Length:	1174	Species:	Mus musculus

Alignment Length:	956	Identity:	203/956 - (21%)
Similarity:	334/956 - (34%)	Gaps:	314/956 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SVDGLLVYFPYEYIYPEQYAYMLELKRSLDAKGHCLLEMPSGTGKTATLLSLIVAY--------- 59
            ::.|:.::||.. .||.|.|.|..:.|.|::..|||||.|:|:||:..||...:|:
Mouse     9 TIGGVKIHFPCR-AYPAQLAMMNSIVRGLNSSQHCLLESPTGSGKSLALLCSALAWQQSLSEKPV 72

  Fly    60 ---MVEHPET---------VRKLIYCSRTV--------------------------PE------- 79
               :.:.||.         .:...|....:                          ||
Mouse    73 DEGLNKKPEAPPSCSCACHSKNFTYSDTNLDTSPHFNSPSKPSSGRNGVSTPCQDSPEKNTLAAK 137

  Fly    80 ------------------IEKV-IAELQNLMVYYERHC-------------------PNPP---- 102
                              :||. |..|:......:|||                   |..|
Mouse   138 LSAKKQASIHRDEDDDFQVEKKRIRPLETTQQIRKRHCLEKDVHHVDARLASEKRVKPESPIGKS 202

  Fly   103 ----------------------------------------------------------------- 102

Mouse   203 FSDRKDSFQNVDGLCSRCCCSAKQGNNQEPANTVKKDHGGQCKRPKIYFGTRTHKQIAQITRELR 267

  Fly   103 -------PFTGLVLSSRKNMCIHPEV-----SKEREGKAVDGKCYGLTASYIRERHEMDTETPIC 155
                   |.|  :||||.:.|:||||     .||:..:.:||| :|.:..:....|::..:..:
Mouse   268 KTAYSGVPMT--ILSSRDHSCVHPEVVGNFNRKEKCMELLDGK-HGKSCYFYHGVHKISNQQTL- 328

  Fly   156 QYFEGFSLEGKESTLPVGVYSIDDLKEYGRSRNWCPYFLARYAIAHAHIVVYSYHYLLDPKIAQV 220
            |:.:|.|          ..:.|::|...||....|||:.||..|..|.||...|:||||.:|.:.
Mouse   329 QHLQGMS----------RAWDIEELVSLGRKLKACPYYTARELIEDADIVFCPYNYLLDSQIRET 383

  Fly   221 VSKEMSRESCVVFDEAHNIDNVCIDSMSVKINRRTVERSTNALNHLTKLVQDIREEDTNRLNEEY 285
            :..:: :...|:.||||||::...:|.|..:
Mouse   384 MDIKL-KGQVVILDEAHNIEDCARESASYSV---------------------------------- 413

  Fly   286 QRMVQGLKDASVQRDTDMILANPVLPNDVLTEVVPGNIRNADH--FLSFLRRFIEYIKTRLRVHH 348
                           |::.|.   ...|.|..::.||||...|  ........|.:::|..:  |
Mouse   414 ---------------TEVQLR---FARDELDSLINGNIRKKSHEPLRDVCYNLINWLETNSK--H 458

  Fly   349 VVQESPAGFLKDISS--------KICIERKPLRFCAERLSSLLRTLE----------------IS 389
            :|:.......|..|.        ::.|...........||::|:..|                ||
Mouse   459 LVERGYESSCKIWSGNEMLLNLYRMGITTATFPVLQRHLSAVLQKEEKVTPIHGKEEAIQIPIIS 523

  Fly   390 DLTEY---GALTLITHFATLVSTYTKGFTIIIE---------PFDDKTPTVSNP----------- 431
            ..|:.   |...::.:.....|.:...:.:.|:         ...|||..::.|
Mouse   524 ASTQVVLKGLFMVLDYLFRENSRFADDYKVAIQQTYSWTNQIAIFDKTGVLAVPKNKKHSRQKIG 588

  Fly   432 --ILHFSCLDSSIAMAPVFSRFQTVVITSGTLSPMDMYPKILDFDPVVMSSFTMTLARPCLLPMI 494
              .|:|.||:.::|.:.:..:.:|:|:|||||||:..:...|.....:.......::...:....
Mouse   589 VNALNFWCLNPAVAFSDINDKVRTIVLTSGTLSPLKSFSSELGVTFSIQLEANHVISNSQVWVGT 653

  Fly   495 VSKGNDQVTISSKFETREDTAVIRNYGQLLVEVAKTVPDGIVCFFTSYLYLESVVASWYDQGIVD 559
            |..|.....:.:.|:..|........|.||:.|.:||..||:||..||..||.:...|...|:..
Mouse   654 VGSGPKGRNLCATFQHTETFEFQDEVGMLLLSVCQTVSQGILCFLPSYKLLEKLRERWIFTGLWH 718

  Fly   560 TLLRYKLLFIETQDNAETSY--ALMNYVKAC------DCGRGAVLLAVARGKVSEGVDFDHHYGR 616
            :|...|.:..|.|...:|.:  .|..|..|.      |   ||:|:||.|||||||:||.....|
Mouse   719 SLESVKTVIAEPQGGEKTDFDELLQVYYDAIKFKGEKD---GALLIAVCRGKVSEGLDFSDDNAR 780

  Fly   617 AVLMFGIPYVYTQSRILKARLDY----LRDQFQIRENDFLTFDAMRHAAQCVGRALRGKTDYGIM 677
            ||:..|||:...:...::.:..|    .:.:..:....:....|.|...|.:||.:|.|.|:|.:
Mouse   781 AVITVGIPFPNVKDLQVELKRQYNDHHSKSRGLLPGRQWYEIQAYRALNQALGRCIRHKNDWGAL 845

  Fly   678 IFADKRFSRHDKR--SRLPKWIQEHLV--DSFCNLSTEEAVQLARR 719
            |..|.||:.:..|  |.|.||:::.:.  .||.: :.|...:.:||
Mouse   846 ILVDDRFNNNPNRYISGLSKWVRQQIQHHSSFAS-ALESLTEFSRR 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Xpd	NP_726036.2	rad3	7..717	CDD:273169	201/949 (21%)
		DEXDc2	8..280	CDD:214693	84/444 (19%)
		HBB	270..413	CDD:284245	25/171 (15%)
		HELICc2	542..686	CDD:214694	48/155 (31%)
Brip1	NP_840094.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..160		4/58 (7%)
		Nuclear localization signal. /evidence=ECO:0000255	158..175		4/16 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	187..208		2/20 (10%)
		rad3	248..884	CDD:273169	165/708 (23%)
		DEAD_2	251..418	CDD:284209	50/230 (22%)
		DEAH box	393..396		1/2 (50%)
		Helicase_C_2	683..869	CDD:290046	62/188 (33%)
		Interaction with BRCA1. /evidence=ECO:0000250	888..1063		2/3 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	923..1001
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1102..1155
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1199
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141017at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820