Protein Alignment Xpd and ERCC2

DIOPT Version :10

• Sequence 1: NP_726036.2
• Gene: Xpd / 37414
• FlyBaseID: FBgn0261850
• Length: 769
• Species: Drosophila melanogaster
• Sequence 2: NP_000391.1
• Gene: ERCC2 / 2068
• HGNCID: 3434
• Length: 760
• Species: Homo sapiens
• Alignment Length: 758
• Identity: 521/758 - (68%)
• Similarity: 636/758 - (83%)
• Gaps: 1/758 - (0%)

  Fly     1 MKLSVDGLLVYFPYEYIYPEQYAYMLELKRSLDAKGHCLLEMPSGTGKTATLLSLIVAYMVEHPE 65
            |||:||||||||||:||||||::||.||||:||||||.:||||||||||.:||:||:||...:|.
Human     1 MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQRAYPL 65

  Fly    66 TVRKLIYCSRTVPEIEKVIAELQNLMVYYERHCPNPPPFTGLVLSSRKNMCIHPEVSKEREGKAV 130
            .|.||||||||||||||||.||:.|:.:||:......||.||.||||||:||||||:..|.||.|
Human    66 EVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDV 130

  Fly   131 DGKCYGLTASYIRERHEMDTETPICQYFEGFSLEGKESTLPVGVYSIDDLKEYGRSRNWCPYFLA 195
            ||||:.|||||:|.:::.||..|.|:::|.|...|:|..||.|:|::||||..||.:.|||||||
Human   131 DGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLA 195

  Fly   196 RYAIAHAHIVVYSYHYLLDPKIAQVVSKEMSRESCVVFDEAHNIDNVCIDSMSVKINRRTVERST 260
            ||:|.||::||||||||||||||.:||||::|::.|||||||||||||||||||.:.|||::|..
Human   196 RYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQ 260

  Fly   261 NALNHLTKLVQDIREEDTNRLNEEYQRMVQGLKDASVQRDTDMILANPVLPNDVLTEVVPGNIRN 325
            ..|..|.|.|..|:|.|..||.:||:|:|:||::||..|:||..|||||||::||.|.|||:||.
Human   261 GNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRT 325

  Fly   326 ADHFLSFLRRFIEYIKTRLRVHHVVQESPAGFLKDISSKICIERKPLRFCAERLSSLLRTLEISD 390
            |:|||.||||.:||:|.||||.|||||||..||..::.::||:|||||||||||.|||.||||:|
Human   326 AEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITD 390

  Fly   391 LTEYGALTLITHFATLVSTYTKGFTIIIEPFDDKTPTVSNPILHFSCLDSSIAMAPVFSRFQTVV 455
            |.::..|||:.:||||||||.||||||||||||:|||::||||||||:|:|:|:.|||.|||:|:
Human   391 LADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVI 455

  Fly   456 ITSGTLSPMDMYPKILDFDPVVMSSFTMTLARPCLLPMIVSKGNDQVTISSKFETREDTAVIRNY 520
            ||||||||:|:|||||||.||.|::|||||||.||.|||:.:|||||.||||||||||.||||||
Human   456 ITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNY 520

  Fly   521 GQLLVEVAKTVPDGIVCFFTSYLYLESVVASWYDQGIVDTLLRYKLLFIETQDNAETSYALMNYV 585
            |.||:|::..||||||.|||||.|:||.|||||:|||::.:.|.|||||||||.||||.||..|.
Human   521 GNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQ 585

  Fly   586 KACDCGRGAVLLAVARGKVSEGVDFDHHYGRAVLMFGIPYVYTQSRILKARLDYLRDQFQIREND 650
            :||:.||||:||:|||||||||:||.|||||||:|||:||||||||||||||:||||||||||||
Human   586 EACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIREND 650

  Fly   651 FLTFDAMRHAAQCVGRALRGKTDYGIMIFADKRFSRHDKRSRLPKWIQEHLVDSFCNLSTEEAVQ 715
            |||||||||||||||||:|||||||:|:||||||:|.|||.:||:||||||.|:..||:.:|.||
Human   651 FLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQ 715

  Fly   716 LARRWLRRMAQPFTREDQLGISLLTLAQLENMEQ-EKLERQAQ 757
            :|:.:||:|||||.||||||:|||:|.|||:.|. :::|:.||
Human   716 VAKYFLRQMAQPFHREDQLGLSLLSLEQLESEETLKRIEQIAQ 758

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Xpd	NP_726036.2	rad3	7..717	CDD:273169	491/709 (69%)
ERCC2	NP_000391.1	rad3	7..708	CDD:273169	486/700 (69%)
		DEAH box	234..237		2/2 (100%)
		Mediates interaction with MMS19	438..637		146/198 (74%)
		Nuclear localization signal. /evidence=ECO:0000255	682..695		8/12 (67%)