DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Xpd and ERCC2

DIOPT Version :9

Sequence 1:	NP_726036.2	Gene:	Xpd / 37414	FlyBaseID:	FBgn0261850	Length:	769	Species:	Drosophila melanogaster
Sequence 2:	NP_000391.1	Gene:	ERCC2 / 2068	HGNCID:	3434	Length:	760	Species:	Homo sapiens

Alignment Length:	758	Identity:	521/758 - (68%)
Similarity:	636/758 - (83%)	Gaps:	1/758 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKLSVDGLLVYFPYEYIYPEQYAYMLELKRSLDAKGHCLLEMPSGTGKTATLLSLIVAYMVEHPE 65
            |||:||||||||||:||||||::||.||||:||||||.:||||||||||.:||:||:||...:|.
Human     1 MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQRAYPL 65

  Fly    66 TVRKLIYCSRTVPEIEKVIAELQNLMVYYERHCPNPPPFTGLVLSSRKNMCIHPEVSKEREGKAV 130
            .|.||||||||||||||||.||:.|:.:||:......||.||.||||||:||||||:..|.||.|
Human    66 EVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDV 130

  Fly   131 DGKCYGLTASYIRERHEMDTETPICQYFEGFSLEGKESTLPVGVYSIDDLKEYGRSRNWCPYFLA 195
            ||||:.|||||:|.:::.||..|.|:::|.|...|:|..||.|:|::||||..||.:.|||||||
Human   131 DGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLA 195

  Fly   196 RYAIAHAHIVVYSYHYLLDPKIAQVVSKEMSRESCVVFDEAHNIDNVCIDSMSVKINRRTVERST 260
            ||:|.||::||||||||||||||.:||||::|::.|||||||||||||||||||.:.|||::|..
Human   196 RYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQ 260

  Fly   261 NALNHLTKLVQDIREEDTNRLNEEYQRMVQGLKDASVQRDTDMILANPVLPNDVLTEVVPGNIRN 325
            ..|..|.|.|..|:|.|..||.:||:|:|:||::||..|:||..|||||||::||.|.|||:||.
Human   261 GNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRT 325

  Fly   326 ADHFLSFLRRFIEYIKTRLRVHHVVQESPAGFLKDISSKICIERKPLRFCAERLSSLLRTLEISD 390
            |:|||.||||.:||:|.||||.|||||||..||..::.::||:|||||||||||.|||.||||:|
Human   326 AEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITD 390

  Fly   391 LTEYGALTLITHFATLVSTYTKGFTIIIEPFDDKTPTVSNPILHFSCLDSSIAMAPVFSRFQTVV 455
            |.::..|||:.:||||||||.||||||||||||:|||::||||||||:|:|:|:.|||.|||:|:
Human   391 LADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVI 455

  Fly   456 ITSGTLSPMDMYPKILDFDPVVMSSFTMTLARPCLLPMIVSKGNDQVTISSKFETREDTAVIRNY 520
            ||||||||:|:|||||||.||.|::|||||||.||.|||:.:|||||.||||||||||.||||||
Human   456 ITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNY 520

  Fly   521 GQLLVEVAKTVPDGIVCFFTSYLYLESVVASWYDQGIVDTLLRYKLLFIETQDNAETSYALMNYV 585
            |.||:|::..||||||.|||||.|:||.|||||:|||::.:.|.|||||||||.||||.||..|.
Human   521 GNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQ 585

  Fly   586 KACDCGRGAVLLAVARGKVSEGVDFDHHYGRAVLMFGIPYVYTQSRILKARLDYLRDQFQIREND 650
            :||:.||||:||:|||||||||:||.|||||||:|||:||||||||||||||:||||||||||||
Human   586 EACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIREND 650

  Fly   651 FLTFDAMRHAAQCVGRALRGKTDYGIMIFADKRFSRHDKRSRLPKWIQEHLVDSFCNLSTEEAVQ 715
            |||||||||||||||||:|||||||:|:||||||:|.|||.:||:||||||.|:..||:.:|.||
Human   651 FLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQ 715

  Fly   716 LARRWLRRMAQPFTREDQLGISLLTLAQLENMEQ-EKLERQAQ 757
            :|:.:||:|||||.||||||:|||:|.|||:.|. :::|:.||
Human   716 VAKYFLRQMAQPFHREDQLGLSLLSLEQLESEETLKRIEQIAQ 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Xpd	NP_726036.2	rad3	7..717	CDD:273169	491/709 (69%)
		DEXDc2	8..280	CDD:214693	173/271 (64%)
		HBB	270..413	CDD:284245	89/142 (63%)
		HELICc2	542..686	CDD:214694	115/143 (80%)
ERCC2	NP_000391.1	rad3	7..708	CDD:273169	486/700 (69%)
		DEAH box	234..237		2/2 (100%)
		Mediates interaction with MMS19	438..637		146/198 (74%)
		Nuclear localization signal. /evidence=ECO:0000255	682..695		8/12 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157755
Domainoid	1	1.000	292	1.000	Domainoid score	I1521
eggNOG	1	0.900	-	-		E1_COG1199
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H344
Inparanoid	1	1.050	1080	1.000	Inparanoid score	I245
Isobase	1	0.950	-	0	Normalized mean entropy	S304
OMA	1	1.010	-	-		QHG62382
OrthoDB	1	1.010	-	-		D141017at33208
OrthoFinder	1	1.000	-	-		FOG0005257
OrthoInspector	1	1.000	-	-		oto89418
orthoMCL	1	0.900	-	-		OOG6_101742
Panther	1	1.100	-	-	LDO	PTHR11472
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1054
SonicParanoid	1	1.000	-	-		X3778
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750