DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Xpd and chl-1

DIOPT Version :9

Sequence 1:	NP_726036.2	Gene:	Xpd / 37414	FlyBaseID:	FBgn0261850	Length:	769	Species:	Drosophila melanogaster
Sequence 2:	NP_499295.2	Gene:	chl-1 / 176457	WormBaseID:	WBGene00010839	Length:	830	Species:	Caenorhabditis elegans

Alignment Length:	685	Identity:	158/685 - (23%)
Similarity:	285/685 - (41%)	Gaps:	108/685 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 EHPETVRKLIYCSRTVPEIEKVIAELQNLMVYYERHCPNPPPFTGLVLSSRKNMCIHPEVSKERE 126
            |.|....|:.|.|||..::|::..||..     .|..|..     :..:||..:|::.||.|.:.
Worm   178 EKPLKCLKIFYASRTHSQLEQLAEELAK-----TRFQPRI-----VTCASRGTLCVNEEVKKLKL 232

  Fly   127 GKAVDGKCYGLTASYIRERHEMD---------TET--PICQYFEGFSLEG---------KESTLP 171
            ...::.||..|..:.:.|:.::.         |:|  ..|:::....:|.         .:|||
Worm   233 NHLINEKCMELRKNGMSEKEKVQKLEKGTTKKTKTCATSCEFYNSTQIEDVVNGVLSNKLKSTL- 296

  Fly   172 VGVYSIDDLKEYGRSRNWCPYFLARYAIAHAHIVVYSYHYLLDPKIAQVVSKEMSRESCVVFDEA 236
                   ::.:.|:..|.||||..|.::....:|:..|..||.....:....|: :::.:|.|||
Worm   297 -------EVSKQGKLSNGCPYFATRKSVPQCQLVLLPYQVLLHDGTRKAWGIEL-KDNVIVLDEA 353

  Fly   237 HNIDNVCIDSMSVKINRRTVERSTNALNHLTKLVQDIREEDTNRL---NEEYQRMVQGLKDASVQ 298
            ||:.|......|.:|       ||.:|....:|:::.......:|   |..|.:.::.|....
Worm   354 HNVLNTISSLYSAEI-------STKSLTLALRLIREYNAHYKLKLLAHNLLYMKQLESLTSKM-- 409

  Fly   299 RDTDMILANPVLPNDVLTEVVPGNIRNADHFLSFLRRFIEYI-KT-----------RLRVHHVVQ 351
                :|..|.....||:|  :....||.:.....|.:..||: ||           ||:...:.:
Worm   410 ----LIFLNSQSKEDVMT--MAQLARNLNILEINLFKLAEYMEKTDLCKKFHGFYMRLQKEEIKK 468

  Fly   352 ESPAGFLKDISSKICI-------ERKPLRFCAERLSSLLRTLEISDLTEYGALTLITHFATLVST 409
            |:....|..|...:..       |.:||. ..:.:.|.|.:|:              .|...::.
Worm   469 ENEKPKLTGIQKLMAAKEAEPEPEAEPLP-PPKPVPSPLFSLK--------------SFIDALTN 518

  Fly   410 YTKGFTIIIEPFDDKTPTVSNPILHFSCLDSSIAMAPVFSRFQTVVITSGTLSPMDMYPKILD-- 472
            ..:...||:|    |:.|.:.  ..|..|:.:..::.|.:..:..::..||:.|..:..:.|.
Worm   519 KCEDGRIIVE----KSATEAK--FRFMLLNPADRLSEVVTSARATILVGGTMEPAQLLVETLSRG 577

  Fly   473 ---FDPVVMSSFTMTLARPCLLPMIVSKGNDQVTISSKFETREDTAVIRNYGQLLVEVAKTVPDG 534
               .|.:...|....:....||.:.|.:..|.......::||.....:|:....:..:...:|:|
Worm   578 SIGADSIRRFSCCHVIDDSQLLAVTVERTVDGKPFQLTYQTRGADTTLRSLATSIQALIPHIPNG 642

  Fly   535 IVCFFTSYLYLESVVASWYDQGIVDTLLRYKLLFIETQDNAETSYALMNYVKACDCGRGAVLLAV 599
            :|.|..||.:|.:......:.||:..:...|.:|  |:....||.....:.:|....:||:|.||
Worm   643 VVIFVPSYDFLFNFQKKMKEFGILKRIEEKKAVF--TESRQPTSDVWDRFSRAAKTSKGAILFAV 705

  Fly   600 ARGKVSEGVDFDHHYGRAVLMFGIPYVYTQSRILKARLDYLRDQFQIRENDFLTFDAM-RHAA-Q 662
            ..||:|||::|....||||::.|:||....|..|:.|:.:|..|.....|  |.:::: .||. |
Worm   706 VGGKMSEGINFCDELGRAVIVIGLPYPNKTSVELRERMKFLDTQMPNGGN--LLYESLCMHAVNQ 768

  Fly   663 CVGRALRGKTDYGIMIFADKRFSRHDKRSRLPKWI 697
            .:|||:|.:.||..:...|.|:::...|.:|..||
Worm   769 AIGRAIRHRRDYAAVYLFDDRYAKESTRRKLSTWI 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Xpd	NP_726036.2	rad3	7..717	CDD:273169	158/685 (23%)
		DEXDc2	8..280	CDD:214693	54/237 (23%)
		HBB	270..413	CDD:284245	28/164 (17%)
		HELICc2	542..686	CDD:214694	46/145 (32%)
chl-1	NP_499295.2	P-loop_NTPase	2..387	CDD:304359	54/234 (23%)
		rad3	121..820	CDD:273169	158/685 (23%)
		Helicase_C_2	632..803	CDD:290046	53/174 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1199
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141017at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820