Protein Alignment Xpd and DDX11

DIOPT Version :10

• Sequence 1: NP_726036.2
• Gene: Xpd / 37414
• FlyBaseID: FBgn0261850
• Length: 769
• Species: Drosophila melanogaster
• Sequence 2: XP_016874408.1
• Gene: DDX11 / 1663
• HGNCID: 2736
• Length: 1091
• Species: Homo sapiens
• Alignment Length: 704
• Identity: 171/704 - (24%)
• Similarity: 274/704 - (38%)
• Gaps: 175/704 - (24%)

  Fly    65 ETVRKLIYCSRTVPEIEKVIAELQNLMVYYERHCPNPPPF---TGLV-LSSRKNMCIHPEVSKER 125
            |.:.|:.|||||..::.:.:.|::.            .||   ..|| |.||:|:|::.:|....
Human   260 EHITKIYYCSRTHSQLAQFVHEVKK------------SPFGKDVRLVSLGSRQNLCVNEDVKSLG 312

  Fly   126 EGKAVDGKCYGLTASYIRERHE----MDTETP---------ICQYF--EGFSLEGKESTLPVGVY 175
            ..:.::.:|..:.    |.|||    .:.|.|         .|.::  |...|...|:.  ..|.
Human   313 SVQLINDRCVDMQ----RSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEAL--AEVK 371

  Fly   176 SIDDLKEYGRSRNWCPYFLARYAIAHAHIVVYSYHYLLDPKIAQVVSKEMSRESCVVFDEAHNID 240
            .::.|...|:....|||:.:|.||..|.:||..|..||.....|.....: ::..|:.|||||:
Human   372 DMEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATRQAAGIRL-QDQVVIIDEAHNL- 434

  Fly   241 NVCIDSMSVKINRRTVERSTNALNHL-TKLVQDIREEDTNRL---NEEYQRMVQGLKDASVQRDT 301
               ||:::   ...:||.|.:.|... ::|:|.: |....||   |..|.:.:..|.:..|....
Human   435 ---IDTIT---GMHSVEVSGSQLCQAHSQLLQYV-ERYGKRLKAKNLMYLKQILYLLEKFVAVLG 492

  Fly   302 DMILANPVLP------------NDVLTEVVPGNIRNADHF---------------LSFLRRFIEY 339
            ..|..||...            ||.|.:   ..|.|.:.|               ..|..|:...
Human   493 GNIKQNPNTQSLSQTGTELKTINDFLFQ---SQIDNINLFKVQRYCEKSMISRKLFGFTERYGAV 554

  Fly   340 IKTRLRVHHVVQESP--AGFLKDISSKICIERKPLRFCAERLSSLLRTLEISDLTEYGALTLITH 402
            ..:|        |.|  |||.:.:.|     .:|.  ..|.|::.....:.|.|.....|..|..
Human   555 FSSR--------EQPKLAGFQQFLQS-----LQPR--TTEALAAPADESQASTLRPASPLMHIQG 604

  Fly   403 FATLVSTYTKGFTIIIEPFDDKTPTVSNPILHFSCLDSSIAMAPVFSRFQTVVITSGTLSPMD-- 465
            |...::|..:...:|:    .:..::|...|.|..|:.::..|.|....:.|||..||:.|..
Human   605 FLAALTTANQDGRVIL----SRQGSLSQSTLKFLLLNPAVHFAQVVKECRAVVIAGGTMQPAAGA 665

  Fly   466 -MYPKIL---------------------------DFDPVVMS----------------SFTMTLA 486
             ..|.:|                           .|...:.|                ||.:.||
Human   666 VETPLLLHSVAPGSHVSQRKLFCGFKLKEKNHDSTFKRCLTSGSSCWPVPGWKLSAWWSFPVCLA 730

  Fly   487 R---------PCL-----------LPMIVSKGNDQVTISSKFETREDTAVIRNYGQLLVEVAKTV 531
            .         |.|           ||:::..|.....:...|:.||...::...|::|..:...|
Human   731 AHLHLQFSAPPWLLPGHVIPPDNILPLVICSGISNQPLEFTFQKRELPQMMDEVGRILCNLCGVV 795

  Fly   532 PDGIVCFFTSYLYLESVVASWYDQGIVDTLLRYKLLFIETQDNAETSYALMNY---VKACDCGR- 592
            |.|:||||.||.||..|.|.|...|::..|...|.:|.|.:...:....|:.|   ::||...|
Human   796 PGGVVCFFPSYEYLRQVHAHWEKGGLLGRLAARKKIFQEPKSAHQVEQVLLAYSRCIQACGQERG 860

  Fly   593 ---GAVLLAVARGKVSEGVDFDHHYGRAVLMFGIPYVYTQSRILKARLDYLRDQ 643
               ||:||:|..||:|||::|..:.||.|:|.|:|:...:|..|:.::.|| ||
Human   861 QVTGALLLSVVGGKMSEGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYL-DQ 913

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Xpd	NP_726036.2	rad3	7..717	CDD:273169	171/704 (24%)
DDX11	XP_016874408.1	rad3	263..918	CDD:273169	170/701 (24%)