DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4266 and NRD1

DIOPT Version :9

Sequence 1:	NP_001097394.1	Gene:	CG4266 / 37411	FlyBaseID:	FBgn0034598	Length:	1306	Species:	Drosophila melanogaster
Sequence 2:	NP_014148.1	Gene:	NRD1 / 855470	SGDID:	S000005195	Length:	575	Species:	Saccharomyces cerevisiae

Alignment Length:	816	Identity:	148/816 - (18%)
Similarity:	248/816 - (30%)	Gaps:	289/816 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LSGLYDSRPPISKAKMAAITKSAMRAIKLYKHVVQSVEKFILKCKPEYKVPGLYVIDSIVR---- 71
            |....|.:..||.:::..:|..|:..|.:...::..:..:...|...:|:..||:||||.|
Yeast    14 LESFKDLKSGISGSRIKKLTTYALDHIDIESKIISLIIDYSRLCPDSHKLGSLYIIDSIGRAYLD 78

  Fly    72 --QSRHQYGMDKDLFAPRFQRNLTETFANLFRCA-----PEDKSRIIRVLNLWQKNNVFKSEVIQ 129
              :|......:|..........|.|....|...|     .:.|.:|..:|::|.::.:|:...:.
Yeast    79 ETRSNSNSSSNKPGTCAHAINTLGEVIQELLSDAIAKSNQDHKEKIRMLLDIWDRSGLFQKSYLN 143

  Fly   130 PIFDLADPNHPIYHQMPPVGGSGGQGGGVGPGPSSSGALSLADISSGPNGLNSSGMEISMNSSGG 194
            .|                                .|...:: |||:  |..|::..::|:
Yeast   144 AI--------------------------------RSKCFAM-DISN--NTANTASQQLSL----- 168

  Fly   195 DDKMGGAMPDLSLGHEKFGGGSSSSKRHYSEQHYSKRQSVVSCSSKTSKSHHHKREYVKSSHDID 259
            |.|                               .:.:.::|...|
Yeast   169 DPK-------------------------------QRSKQILSNLKK------------------- 183

  Fly   260 YQVREIIEEEDEGLQMLMADDHHCMGDDSPPTSSNLLDEKKIKQLLNNPNVLRQLHTLQNFQNLK 324
                                        |||.:.|:    .:...|.:.:..:|...|  ||.:
Yeast   184 ----------------------------SPPLNLNI----SLPTDLTSTDPAKQQAAL--FQVI- 213

  Fly   325 PQEENQKHRYQDEALQQHFQNVMKGNAGMPPGMGMGMNMNDSMDLNKDVEFISEQQTIEVINLDG 389
                        .|||:||:.       :|....:|.              ::..|...:  .:.
Yeast   214 ------------AALQKHFKT-------LPSHTSVGT--------------VAPPQAHTI--TEY 243

  Fly   390 GDSRSPTPDRDRYKRSRRNSRSRTRSPRGRGAGGGTG-NDRRRRGTRSRSRSRSPRSSRRRGSRD 453
            |..|....:|:|| .||||   |:|||....:...|| .||.....:.:....:|.::  .|:.:
Yeast   244 GSRRERERERERY-NSRRN---RSRSPPAPFSQPSTGRKDRYPSVAQDQYSIGAPNTT--FGTNN 302

  Fly   454 R----DRMDRSNRDKERDREHERERRKKGLPDIKKEHLSVCSTTLWVGHLSKLVYQEELSDTFGE 514
            .    |.::.||      ..|.|.:.......:..:|:.|.|.||::|.:...:.:.:|::....
Yeast   303 HHLYPDELNVSN------NPHYRPKPVSYDSTLPPDHIKVYSRTLFIGGVPLNMKEWDLANVLKP 361

  Fly   515 YGDIVSIDQIVPRGCAFIVMNRRQDAHKAMQALKNHKLQGR-AITISWAAGKGVKSKEWKDYWDL 578
            :.::.|:.....|..||:.:..|   |:|...|:|....|. .:...|..|.|.     :|..|.
Yeast   362 FAEVQSVILNNSRKHAFVKVYSR---HEAENVLQNFNKDGALPLRTRWGVGFGP-----RDCCDY 418

  Fly   579 ELGVTYIPWSKLSSDTDFDALEEGGMFDEDTMPIQMKQKINQAKNAAKEHKGASIAEAAGAPSV- 642
            :.|.:.||..:|   ||.|                           .|....|.....:|.|.|
Yeast   419 QHGYSIIPMHRL---TDAD---------------------------KKWSVSAQWGGTSGQPLVT 453

  Fly   643 GV--PPPNLIFG-------IDTTQPPPVGPVGPVGPPPGPGAPPPGLMGMVRGQFPMAPPMGINM 698
            |:  ..|::|.|       |....|...|..||....|........:..:..|..|:|.|
Yeast   454 GIVFEEPDIIVGEGVSSKAISQKMPTDSGRNGPRSGKPNKSGSISSISPVPYGNAPLASP----- 513

  Fly   699 PPPIMMPPTNMPPPMMMPTTNMPPPMMMPPTMMPPGFPGIGGPPHPMALPPGAPFPP--PGAVPP 761
                  ||.....|||.                           .|....|..|.|.  |.|..|
Yeast   514 ------PPQQYVQPMMQ---------------------------QPYGYAPNQPLPSQGPAAAAP 545

  Fly   762 PIPSGGQISNSGNVSDDQMDIEMDLEDAPPLPPQQQ 797
            |:|            ..|.|....|.....:..|||
Yeast   546 PVP------------QQQFDPTAQLNSLMNMLNQQQ 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4266	NP_001097394.1	CID	7..125	CDD:239621	27/124 (22%)
		RRM	<488..>593	CDD:223796	25/105 (24%)
		RRM_SCAF4_SCAF8	490..566	CDD:240673	17/76 (22%)
		DUF2413	1147..>1254	CDD:287302
		Herpes_DNAp_acc	<1206..1304	CDD:282746
NRD1	NP_014148.1	CID_Nrd1_like	8..149	CDD:340781	29/166 (17%)
NRD1	NP_014148.1	RRM_NRD1_SEB1_like	336..412	CDD:409768	18/78 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0132
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23189
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1302
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.030