DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4266 and Rbm15

DIOPT Version :9

Sequence 1:	NP_001097394.1	Gene:	CG4266 / 37411	FlyBaseID:	FBgn0034598	Length:	1306	Species:	Drosophila melanogaster
Sequence 2:	XP_003749428.1	Gene:	Rbm15 / 684233	RGDID:	1592713	Length:	962	Species:	Rattus norvegicus

Alignment Length:	873	Identity:	174/873 - (19%)
Similarity:	267/873 - (30%)	Gaps:	317/873 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 APRFQR--NLTETFANLFRCAPEDKSRIIRVLNLWQKNNVFKSEVIQPIFDLADPNHPIY----- 142
            :||::|  .|.||.|.                  |:.:.:.:.::.:|.........|:.
  Rat    13 SPRWRRASPLCETSAG------------------WRVSQLRRDDLRRPSTMKGKERSPVKPKRSR 59

  Fly   143 ---------HQMPPVGGSGGQGGGVGPGPSSSGALSLADISSGPNGLNSSGMEISMNSSGGDDKM 198
                     .:...:|||||..|      ||||...        :|.:...:.:..:||.|
  Rat    60 GGEDSSSRGERSKKLGGSGGSNG------SSSGKTD--------SGGSRRSLHLDKSSSRG---- 106

  Fly   199 GGAMPDLSLGHEKF--GGGSSSSKRHYSEQHYSKRQSVVSCSSKTSKSHHHKREYVKSSHDIDYQ 261
                     |..::  |||||||:.|          |..|.|:|.|......|...:....
  Rat   107 ---------GSREYDTGGGSSSSRLH----------SYSSPSTKNSSGGGESRSSSRGGGG---- 148

  Fly   262 VREIIEEEDEGLQMLMADDHHCMGDDSPPTSSNLLDEKKIKQLLNNPNVLRQLHTLQNFQNLKPQ 326
                 |....|            ...|.|...:.::.|.:|        :.:|.:
  Rat   149 -----ESRSSG------------AASSAPGGGDGVEYKTLK--------ISELGS---------- 178

  Fly   327 EENQKHRYQDEALQQHFQNVMK--GNAGMP----PGMGMGMNMNDSMDLNKDVEFISEQQTIEVI 385
                  :..|||::....:..|  |:..:.    .|.|.|         ::.|.|::.::.
  Rat   179 ------QLSDEAVEDGLFHEFKRFGDVSVKISHLSGSGSG---------DERVAFVNFRRP---- 224

  Fly   386 NLDGGDSRSPTPDRDR---YKR---------SRRNSRS----RTRSPRGRGAGGGTGNDRRRRGT 434
                .|:|:....|.|   |.|         |||.|||    .|.:|.....|...|:.|...|.
  Rat   225 ----EDARAAKHARGRLVLYDRPLKIEAVYVSRRRSRSPLDKDTYAPSSSVVGSSVGSHRHAPGG 285

  Fly   435 RSRSRSRSPRSSRRRGSRDRDRMDR-------------SNRDKERDRE---HERERRKKGL---- 479
            ....||.|| .....|.||. |:.:             ..|:.||:|:   ::|.|....|
  Rat   286 GGGQRSLSP-GGAALGYRDY-RLQQLALGRLPPPPPPPLPRELERERDYPFYDRVRPAYSLEPRV 348

  Fly   480 ------------PDIKKEHLSVCSTTLWVGHLSKLVYQEELSDTFGEYGDIVSIDQIVP-RG--- 528
                        .:|..|.....:.||::|:|...|.:.:|...|..:|.|..:|...| ||
  Rat   349 GAGAGAAPFREVDEISPEDDQRANRTLFLGNLDITVTENDLRRAFDRFGVITEVDIKRPSRGQTS 413

  Fly   529 -CAFIVMNRRQDAHKAMQALKNHKLQGRAITISWAAGKGVKSKEWKDYWDLELGVTYIPWSKLSS 592
             ..|:.......:|:|..|:....:....|.|.:  ||...:..   .|...||    ||..|::
  Rat   414 TYGFLKFENLDMSHRAKIAMSGKIIIRNPIKIGY--GKATPTTR---LWVGGLG----PWVPLAA 469

  Fly   593 -DTDFDALEEGGMFDEDTMPIQMKQKINQAKN---AAKEHKGASIAEAAGAPSVGVP--PPNLIF 651
             ..:||..        .|:     :.|:..|.   |..:::....|.||.....|.|  .|:...
  Rat   470 LAREFDRF--------GTI-----RTIDYRKGDSWAYIQYESLDAAHAAWTHMRGFPLGGPDRRL 521

  Fly   652 GIDTT-----------QPPPVGPVGPVGPPPGPGAPPPGLMGMVRGQFPMAPPMGINMPPPIMMP 705
            .:|..           ||.|:.....|....|..||.|     :|......||:........:.|
  Rat   522 RVDFADTEHRYQQQYLQPLPLTHYELVTDTFGHRAPDP-----LRSARDRTPPLLYRDRDRDLYP 581

  Fly   706 PTNMPPPMMMPTTNMPPPM--------MMPPTMMPP--------------------GFPGIGGPP 742
            .::..||        |||:        ....|...|                    ..|.....|
  Rat   582 DSDWVPP--------PPPVRERSARAATSAVTAYEPLDSLDRRRDGWSLDRDRGDRDLPSSRDQP 638

  Fly   743 HPMALPPGAPFPPPGAVPPPIPSGGQISNSGNVSDDQMDIEMDLEDAPPLPPQQQANFNPSPSNV 807
            ....||.              .|||:..:....||               .|::|.:..|||
  Rat   639 RKRRLPE--------------ESGGRHLDRSPESD---------------RPRKQRHCTPSP--- 671

  Fly   808 DLSPAAMANEMFQQRDRERDRDNRDRSR 835
            |.||...:|         |||.|.|..|
  Rat   672 DRSPELSSN---------RDRYNSDNDR 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4266	NP_001097394.1	CID	7..125	CDD:239621	8/41 (20%)
		RRM	<488..>593	CDD:223796	27/110 (25%)
		RRM_SCAF4_SCAF8	490..566	CDD:240673	20/80 (25%)
		DUF2413	1147..>1254	CDD:287302
		Herpes_DNAp_acc	<1206..1304	CDD:282746
Rbm15	XP_003749428.1	RRM1_RBM15	168..250	CDD:240997	19/122 (16%)
		RRM2_RBM15	366..452	CDD:240999	22/87 (25%)
		RRM3_RBM15	455..527	CDD:241001	19/91 (21%)
		SPOC	789..925	CDD:285043
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23189
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100