DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4266 and RBM15

DIOPT Version :9

Sequence 1:	NP_001097394.1	Gene:	CG4266 / 37411	FlyBaseID:	FBgn0034598	Length:	1306	Species:	Drosophila melanogaster
Sequence 2:	NP_073605.4	Gene:	RBM15 / 64783	HGNCID:	14959	Length:	977	Species:	Homo sapiens

Alignment Length:	823	Identity:	174/823 - (21%)
Similarity:	255/823 - (30%)	Gaps:	283/823 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 VGGSGGQGGGVGPGPSSSGALSLADISSGPNGLNSSGMEISMNSSGGDDKMGGAMPDLSL----- 207
            :|||||..|                                 :|||..|..||:...|.|
Human    74 LGGSGGSNG---------------------------------SSSGKTDSGGGSRRSLHLDKSSS 105

  Fly   208 --GHEKF--GGGSSSSKRHYSEQHYSKRQSVVSCSSKTSKSHHHKREYVKSSHDIDYQVREIIEE 268
              |..::  |||||||:.|          |..|.|:|.|......|...:....         |.
Human   106 RGGSREYDTGGGSSSSRLH----------SYSSPSTKNSSGGGESRSSSRGGGG---------ES 151

  Fly   269 EDEGLQMLMADDHHCMGDDSPPTSSNLLDEKKIKQLLNNPNVLRQLHTLQNFQNLKPQEENQKHR 333
            ...|            ...|.|...:..:.|.:|        :.:|.:                :
Human   152 RSSG------------AASSAPGGGDGAEYKTLK--------ISELGS----------------Q 180

  Fly   334 YQDEALQQHFQNVMK--GNAGMP----PGMGMGMNMNDSMDLNKDVEFISEQQTIEVINLDGGDS 392
            ..|||::....:..|  |:..:.    .|.|.|         ::.|.|::.::.        .|:
Human   181 LSDEAVEDGLFHEFKRFGDVSVKISHLSGSGSG---------DERVAFVNFRRP--------EDA 228

  Fly   393 RSPTPDRDR---YKR---------SRRNSRS----RTRSPRGRGAGGGTGNDRRRRGTRSRSRSR 441
            |:....|.|   |.|         |||.|||    .|..|.....|...|..|...|.....||.
Human   229 RAAKHARGRLVLYDRPLKIEAVYVSRRRSRSPLDKDTYPPSASVVGASVGGHRHPPGGGGGQRSL 293

  Fly   442 SPRSSRRRGSRDRDRMDR-------------SNRDKERDRE---HERERRKKGL----------- 479
            || .....|.||. |:.:             ..||.||:|:   :||.|....|
Human   294 SP-GGAALGYRDY-RLQQLALGRLPPPPPPPLPRDLERERDYPFYERVRPAYSLEPRVGAGAGAA 356

  Fly   480 -----PDIKKEHLSVCSTTLWVGHLSKLVYQEELSDTFGEYGDIVSIDQIVP-RG----CAFIVM 534
                 .:|..|.....:.||::|:|...|.:.:|...|..:|.|..:|...| ||    ..|:..
Human   357 PFREVDEISPEDDQRANRTLFLGNLDITVTESDLRRAFDRFGVITEVDIKRPSRGQTSTYGFLKF 421

  Fly   535 NRRQDAHKAMQALKNHKLQGRAITISWAAGKGVKSKEWKDYWDLELGVTYIPWSKLSS-DTDFDA 598
            .....:|:|..|:....:....|.|.:  ||...:..   .|...||    ||..|:: ..:||.
Human   422 ENLDMSHRAKLAMSGKIIIRNPIKIGY--GKATPTTR---LWVGGLG----PWVPLAALAREFDR 477

  Fly   599 LEEGGMFDEDTMPIQMKQKINQAKN---AAKEHKGASIAEAAGAPSVGVP--PPNLIFGIDTT-- 656
            .        .|:     :.|:..|.   |..:::....|.||.....|.|  .|:....:|..
Human   478 F--------GTI-----RTIDYRKGDSWAYIQYESLDAAHAAWTHMRGFPLGGPDRRLRVDFADT 529

  Fly   657 ---------QPPPVGPVGPVGPPPGPGAPPPGLMGMVRGQFPMAPPMGINMPPPIMMPPTNMPPP 712
                     ||.|:.....|....|..||.|     :||.....||:........:.|.::..||
Human   530 EHRYQQQYLQPLPLTHYELVTDAFGHRAPDP-----LRGARDRTPPLLYRDRDRDLYPDSDWVPP 589

  Fly   713 MMMPTTNMPPPM-----MMPPTMMPPGFP-----------GIGGPPHPMALPPGAPFPPPGAVPP 761
                    |||:     ....|.:|...|           .:........||.....|....:|.
Human   590 --------PPPVRERSTRTAATSVPAYEPLDSLDRRRDGWSLDRDRGDRDLPSSRDQPRKRRLPE 646

  Fly   762 PIPSGGQISNSGNVSDDQMDIEMDLEDAPPLPPQQQANFNPSPSNVDLSPAAMANEMFQQRDR-- 824
              .|||:                .|:.:|.....::.:..|||   |.||     |:...|||
Human   647 --ESGGR----------------HLDRSPESDRPRKRHCAPSP---DRSP-----ELSSSRDRYN 685

  Fly   825 -ERDRDN----------RDRSRGPGNSRWGGRDDVVEAAERWR 856
             :.||.:          ||| ||......|.:.|...:|...|
Human   686 SDNDRSSRLLLERPSPIRDR-RGSLEKSQGDKRDRKNSASAER 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4266	NP_001097394.1	CID	7..125	CDD:239621
		RRM	<488..>593	CDD:223796	27/110 (25%)
		RRM_SCAF4_SCAF8	490..566	CDD:240673	20/80 (25%)
		DUF2413	1147..>1254	CDD:287302
		Herpes_DNAp_acc	<1206..1304	CDD:282746
RBM15	NP_073605.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..167		33/156 (21%)
		RRM1_RBM15	169..251	CDD:409969	19/122 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	256..298		13/42 (31%)
		RRM2_RBM15	367..453	CDD:409971	22/87 (25%)
		RRM3_RBM15	456..528	CDD:409973	19/91 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	555..778		46/213 (22%)
		SF-CC1	624..>736	CDD:273721	30/131 (23%)
		SPOC	781..954	CDD:400205
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	865..884
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23189
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100