Protein Alignment Isha and Isha

DIOPT Version :10

• Sequence 1: NP_001097394.1
• Gene: Isha / 37411
• FlyBaseID: FBgn0034598
• Length: 1306
• Species: Drosophila melanogaster
• Sequence 2: XP_061499470.1
• Gene: Isha / 1275046
• VectorBaseID: AGAMI1_002162
• Length: 1444
• Species: Anopheles gambiae
• Alignment Length: 1585
• Identity: 569/1585 - (35%)
• Similarity: 716/1585 - (45%)
• Gaps: 449/1585 - (28%)

  Fly     1 METVVAFNNELSGLYDSRPPISKAKMAAITKSAMRAIKLYKHVVQSVEKFILKCKPEYKVPGLYV 65
            ||||..||.||||||:|:|||||||||:||:|||:|||.||||||||||||.|||.|||:|||||
Mosquito     1 METVRVFNQELSGLYESKPPISKAKMASITRSAMKAIKFYKHVVQSVEKFIQKCKCEYKIPGLYV 65

  Fly    66 IDSIVRQSRHQYGMDKDLFAPRFQRNLTETFANLFRCAPEDKSRIIRVLNLWQKNNVFKSEVIQP 130
            |||||||||||:|.:||:|||||.||:..|||:||||.|||||:|||||||||||.||..|||||
Mosquito    66 IDSIVRQSRHQFGPEKDVFAPRFARNMESTFAHLFRCPPEDKSKIIRVLNLWQKNMVFLPEVIQP 130

  Fly   131 IFDLADPNHPIYHQMPPVGGSGGQGGGVGPGPSSSGALSLADISSGPNGLNSSGMEISMNSSGGD 195
            :||||:|:|||:.|.                    .|..|.:.::|.||:|..|:.   :.|...
Mosquito   131 LFDLANPDHPIHQQY--------------------NAQVLQEQAAGANGMNPGGLP---HDSPVG 172

  Fly   196 DKMGGAMPD----LSLGHEKFGGGSSSSKRHYSEQHYSKRQSVVSCSSKTSKSHHHKREYVKSSH 256
            ..|||.|.|    |.:|..| ....|:.::....|....||:....::..||.   :.::.|...
Mosquito   173 GSMGGGMDDHGGQLQMGETK-QLDPSTIRQLQQFQQILMRQTSGDQANAVSKD---QVKFNKKLL 233

  Fly   257 DIDYQVREIIEEEDEGLQMLMADDHHCMGDDSPPTSSNL-------LDEKKIKQLLNNPNVLRQL 314
            |.||.                :||.......|.|..:|.       :....|.|:|::||||:|
Mosquito   234 DFDYG----------------SDDDDDKNSPSVPLPANAGMPDLSQVPAGNIAQILSDPNVLKQ- 281

  Fly   315 HTLQNFQNLKPQEENQ----KHRYQDEALQQHFQNVMK----GN----AGMPPGMGMGMNMNDSM 367
              |||.|.||.|||.|    :...::|..::|..:|:.    .|    :..||   :.:|...|.
Mosquito   282 --LQNLQKLKQQEEKQTKLSEMMLKEEKFEKHLASVLMKLPFANECDLSRQPP---IDVNAGHSK 341

  Fly   368 DLNKD-------VEFISEQQTIEV-------INLDGGDSRSPTPDRDRYKRSRRNSR--SRTRSP 416
            |::.|       ||.:.:  .|.|       |.|.|..:.|.:.:.||||.|..:||  ||:|||
Mosquito   342 DVDTDNDVSITGVEILGD--PIPVGGSRGGGIGLGGSGTASGSGNNDRYKSSSSSSRRKSRSRSP 404

  Fly   417 RGRGAGGGTGNDRRRRGTRSRSRSRSPRSSRRRGSRDRDRMDRSNRDKERDREHERERRKKGLPD 481
            |.|..||.:|   ||..:.|||||.||||||||.||||.  ..|.:|:||::||||||::||||:
Mosquito   405 RDRRGGGTSG---RRGRSHSRSRSASPRSSRRRSSRDRG--GTSAKDREREKEHERERKRKGLPE 464

  Fly   482 IKKEHLSVCSTTLWVGHLSKLVYQEELSDTFGEYGDIVSIDQIVPRGCAFIVMNRRQDAHKAMQA 546
            :|||||||||||||||||||||.|||||||||:||||||||.|.|||||||||||||||.|.||:
Mosquito   465 MKKEHLSVCSTTLWVGHLSKLVQQEELSDTFGKYGDIVSIDMIPPRGCAFIVMNRRQDAFKCMQS 529

  Fly   547 LKNHKLQGRAITISWAAGKGVKSKEWKDYWDLELGVTYIPWSKLSSDTDFDALEEGGMFDEDTMP 611
            |||||:.||.||||||||||||||||||||||:|||:||||||||..||.:.||:||||||||:|
Mosquito   530 LKNHKMHGRTITISWAAGKGVKSKEWKDYWDLDLGVSYIPWSKLSPSTDLETLEDGGMFDEDTIP 594

  Fly   612 IQMKQKINQAKNAA--------------------------KEHKGASI----AEAAGAPSVGVPP 646
            ..||:|......||                          |:..|:.:    |.||.|.:.|:..
Mosquito   595 QWMKEKSTAGGTAAAGPSAAAAAAAAAAAMGLGLAPGMGLKKLDGSDLSTAAAAAAAAAAAGMLN 659

  Fly   647 PNL--IFGIDTTQPPPVGPVGPVGPPP---GPGAPPPGLMGMVRGQFPMAPPMGINMPPPIMMPP 706
            |:|  :..:||:||||...:| :|.||   ||.|..|..||:..|. .|.|.:|||:|||.||.|
Mosquito   660 PSLFPLSAVDTSQPPPTAMMG-MGMPPFPMGPVARLPIPMGIPMGP-NMVPGLGINVPPPGMMMP 722

  Fly   707 TNMPPPMMMPTTNMPPPMMMPPTMMPPGFPGIGG------------------------------- 740
            .|.||..|.....:|||.....:...||..|.||
Mosquito   723 GNPPPLPMGGFGVLPPPPPSSSSSAAPGMMGNGGGAANLMSSSSNMSKSSADDMDIEMEDEHTSN 787

  Fly   741 -----------------PPHPMALPPGA---PFP-PPG---------AVPPPIP-SGGQISNSGN 774
                             ||.|: :||.|   |.| |||         |..|.:| ||..:.::|.
Mosquito   788 PAPMVGGGQGAGAFFNQPPPPL-MPPTANLGPQPGPPGNVAGFFGGSAAGPNMPGSGPNMPDNGG 851

  Fly   775 VSDDQMDIEMDLEDAPPLPPQQQANFNPSPSNVD--LSPAAMANEMFQQR---DRERDRDNRD-- 832
            :.|...|      ||     ..:||........|  |..:..|.:..:.|   ||.||||.|.
Mosquito   852 MLDGGSD------DA-----DGEANMAGGRGARDGFLHGSDEARDNLRGRGGSDRSRDRDQRGGG 905

  Fly   833 ------------RSRGPGNSRWGGRDDVVEAAERWRAENGGGGGGPGSGLGPN--------AAFN 877
                        |.||...|||||..:          :.|||....|:|.|.|        ....
Mosquito   906 FERGAGGDGGGRRDRGDRGSRWGGGGN----------DRGGGNNFRGTGGGNNQQDDRPLSERLR 960

  Fly   878 EARARLNLNPIEH----------------GMPRPDF----MDFDNRGG-----------PGGPRG 911
            |....|..|..:.                |....||    .||..|||           .||...
Mosquito   961 ELAGVLEFNNQQQRAGGVGVGGGRLFARVGNDGDDFGNRDADFTRRGGNFQQNRFNNNAAGGNGD 1025

  Fly   912 M--------GPRGNHNGGGPGGDFFPPNMNHNRFNQPTSLMQMRIPPPASFN----QRMGG---- 960
            :        ||.||...||.||.|      .||..:..:..|.|  ....||    |:.||
Mosquito  1026 LAGRNQGRNGPFGNQQQGGRGGMF------GNRLGRNNNQQQQR--GGQFFNEDRQQQQGGFFDR 1082

  Fly   961 -----PAGNGGNGVGPMFMRNQGGGPGGAGPSGGGPGGAGTGGGGPGGRQQGPGFFNPRNPFNDN 1020
                 ...:|||..||...||.....||.|.:||.....|..|   .||||     |.|:  .|.
Mosquito  1083 NEDSNGYDSGGNNNGPNNRRNWNDRAGGRGNNGGNNRDEGNRG---RGRQQ-----NWRS--GDE 1137

  Fly  1021 QRGRGGQSGGGVR----------GVGGGGGGGPGGRGRWSDDEDE----------------GGNN 1059
            ..|.||.||||.|          ..|.|||..||...||.||.:.                |.:|
Mosquito  1138 SAGEGGGSGGGQRFNNARGGGNNNRGNGGGNRPGAAARWDDDNESWDDANNRPTTGRQTQFGASN 1202

  Fly  1060 FKRRGGPGGPGGN----------RFRGER---------------------------------GGE 1081
            .:||..    |||          |..|:.                                 .|:
Mosquito  1203 RQRRNS----GGNDEQENDQQEQRREGQSENDDMAICDDQSRHSENDTARDMHNVPLNRQDDDGD 1263

  Fly  1082 MMDDRRGNNSRGGRGGPREDRERP----------------GFGNRRGSRDDSNRH---SISSTDE 1127
            .|.|||...:...|....:| |||                |..::....|::|.|   .....|.
Mosquito  1264 AMGDRRFQRNHHRRNDDADD-ERPQPILYSPEPEEEPDEMGGNDQYAREDNTNYHQGDDNGGQDH 1327

  Fly  1128 GNKAASETEPKPKNVETELGSTNTGAPAAATRVDTEEDWDQELQDYEARMEAQKPGERASQSANS 1192
            .|:....|.......:.:..|:..|..:|..|.:     :|..|:..|...|.:.|.|...:..|
Mosquito  1328 PNRGVEATNELMNQCQPQEDSSQFGGASADDRFE-----EQREQEQAAPSSAMEQGVRDEDNDYS 1387

  Fly  1193 PP--QEKLPAENENFAKPADVTGDPLVAKSQTETSAACTPLYDELPPPAVPQTPTQP-PKEPQGS 1254
            .|  |:.||.::.|                  ||:||.:            .:||.| |.:.|.:
Mosquito  1388 HPEKQQDLPEDDRN------------------ETAAASS------------SSPTMPTPCQEQNN 1422

  Fly  1255 PPRPAPPVIETEAAPHEESVPAPPA 1279
            .|.     :::.....||.....||
Mosquito  1423 EPS-----VQSNDTAEEEPASGEPA 1442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Isha	NP_001097394.1	PHA03247	<1187..1306	CDD:223021	20/96 (21%)
		CID_SCAF8_like	6..135	CDD:340780	102/128 (80%)
		RRM_SCAF4_SCAF8	490..566	CDD:409674	65/75 (87%)
Isha	XP_061499470.1	None