DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30389 and Maco1

DIOPT Version :9

Sequence 1:	NP_001261116.1	Gene:	CG30389 / 37410	FlyBaseID:	FBgn0050389	Length:	1037	Species:	Drosophila melanogaster
Sequence 2:	NP_079658.2	Gene:	Maco1 / 66146	MGIID:	1913396	Length:	664	Species:	Mus musculus

Alignment Length:	925	Identity:	301/925 - (32%)
Similarity:	426/925 - (46%)	Gaps:	300/925 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKRRNADCGKLRRPIKRNKITEGMYGSTTVLYMKFLILWAIVMVADFMFMFRFEFLWPFWLLLRS 65
            ||||||||.|||||:|||:||||:||| |.||:|||::||:|::|||:..||||:||||||.:||
Mouse     1 MKRRNADCSKLRRPLKRNRITEGIYGS-TFLYLKFLVVWALVLLADFVLEFRFEYLWPFWLFIRS 64

  Fly    66 VHDSFKYKGLAFSVLFVCIAITSDLVCLFFIPVHWLLFAASTYVWVQYVWHTDKGICLPTIILWM 130
            |:|||:|:||||||.|||:|.||:::||.|||:.||.|||||||||||||||::|:||||:.||:
Mouse    65 VYDSFRYQGLAFSVFFVCVAFTSNIICLLFIPIQWLFFAASTYVWVQYVWHTERGVCLPTVSLWI 129

  Fly   131 LFVYLEVGIRWKDSRHMPHLDLCRPFAAHCIGYPVVTLGFGFKSYVGYRMRQRKQREVAKDNEFY 195
            ||||:|..||:||.::. |:||||||||||||||||||||||||||.|:||.|||:||.|:||||
Mouse   130 LFVYIEAAIRFKDLKNF-HVDLCRPFAAHCIGYPVVTLGFGFKSYVSYKMRLRKQKEVQKENEFY 193

  Fly   196 MQLLQQALPAEE--------AAEEAAAGQAATSSTVVVANGSATTPALVASSGATAANGVLATAT 252
            |||||||||.|:        .|||||.|.....|::::
Mouse   194 MQLLQQALPPEQQMLQKQEKEAEEAAKGLPDMDSSILI--------------------------- 231

  Fly   253 QAQNHHEHHHSGGAGASSSSSSNSNHHHHHHHNNSSGNSGSNHNSNSSSGGAKDNSTSESASGAA 317
                    ||:||..|:...|:......:.............||.     |..:|:..:..
Mouse   232 --------HHNGGIPANKKLSTTLPEIEYREKGKEKDKDAKKHNL-----GINNNNILQPV---- 279

  Fly   318 ASSITASSATGAALAAAASASSASTTSGSSSSSASTGKQSSSSAASAATTGAATTSSTPVSDFSA 382
                                                                    .:.:.:...
Mouse   280 --------------------------------------------------------DSKIQEIEY 288

  Fly   383 LAASLATQQQQHQSVATAYPATSSARSSSSTSEGVDADGCCGATSNGHAGGSRNHRRSMDKDKHR 447
            :...:.:::..:..|             .||...:..|.|..::.|                 ::
Mouse   289 MENHINSKRLNNDLV-------------GSTENLLKEDSCTASSKN-----------------YK 323

  Fly   448 NKGDAADNEHNNGTRHGGKNSGNNQVDSAATATATVTATSSNSKDKDKEKSDWDSSTSYPQQQQQ 512
            |    |....|:..|.....:|              :..||:||::.|:|     .||
Mouse   324 N----ASGVVNSSPRSHSATNG--------------SIPSSSSKNEKKQK-----CTS------- 358

  Fly   513 GGKEKHEKKAGNAVPNGNANHLEDETASVEPTPPVEKATKGRRNRGKKDNAAKDNHSHQQQLAQQ 577
            .|...|:....|.:||   |.|....|.|
Mouse   359 KGPSAHKDLMENCIPN---NQLSKPDALV------------------------------------ 384

  Fly   578 QKEKDKENTANNNNNDASSVSSSASSTSSNAIANLASKVVSKICETCLKLEADVKKYRAEISHMK 642
                                                            :||.|:||.:|::...:
Mouse   385 ------------------------------------------------RLEQDIKKLKADLQASR 401

  Fly   643 QIENELRQKLDANLTS-----KSTLQAKQKECDDLEKRIQELNNARHADMLNLQTVERRLNEERR 702
            |:|.|||.::.| |:|     :|.:...::|.:.|:.::......:..|..|:..:|::|..|:.
Mouse   402 QVEQELRSQISA-LSSTERGIRSEMGQLRQENELLQNKLHNAVQMKQKDKQNISQLEKKLKAEQE 465

  Fly   703 QKQSLDSQLSNEKKARKLAEEKAARP---------ECSSQCKQRRQQMDEEQKRLRSDLKQAEEA 758
            .:..::.||..|||.:||.|..|||.         ||:...:.|.::::.|.|:|..|:|..||
Mouse   466 ARSFVEKQLMEEKKRKKLEEATAARAVAFAAASRGECTETLRSRIRELEAEGKKLTMDMKVKEE- 529

  Fly   759 KQLAVEHGRKVEQEYRMLEAK---LRNRESSQPDPEILLNALAAMQDKNATLEKNLSAETRVKLD 820
                         :.|.||.|   ||..:.::.|.|:|::||:|||||...||.:||||||:|||
Mouse   530 -------------QIRELELKVQELRKYKENEKDTEVLMSALSAMQDKTQHLENSLSAETRIKLD 581

  Fly   821 LFSALGAAKRQIEISDNHRRSKEDEVIDLKAKIAQLLAVMPD-NLCMNTGPHGP-----SSSILR 879
            ||||||.||||:||:......|:.|:.|||.|||:::||||. .....|.|..|     ||..:
Mouse   582 LFSALGDAKRQLEIAQGQILQKDQEIKDLKQKIAEVMAVMPSITYSAATSPLSPVSPHYSSKFV- 645

  Fly   880 MNDTPPLQSGPGPSS 894
              :|.|  ||..|::
Mouse   646 --ETSP--SGLDPNA 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30389	NP_001261116.1	Macoilin	2..893	CDD:286769	299/921 (32%)
		Ax_dynein_light	<624..711	CDD:287215	22/91 (24%)
		RILP-like	<696..803	CDD:304877	37/118 (31%)
Maco1	NP_079658.2	Macoilin	2..662	CDD:286769	300/924 (32%)
		CarR_dom_SF	29..113	CDD:274590	57/83 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	253..274		3/25 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..375		19/104 (18%)
		TolA_bind_tri	386..462	CDD:292947	21/76 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	630..664		10/32 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843296
Domainoid	1	1.000	356	1.000	Domainoid score	I975
eggNOG	1	0.900	-	-		E1_KOG1821
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14449
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46421
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004783
OrthoInspector	1	1.000	-	-		oto93120
orthoMCL	1	0.900	-	-		OOG6_107355
Panther	1	1.100	-	-	LDO	PTHR13289
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4642
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.710