DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30389 and maco1b

DIOPT Version :9

Sequence 1:	NP_001261116.1	Gene:	CG30389 / 37410	FlyBaseID:	FBgn0050389	Length:	1037	Species:	Drosophila melanogaster
Sequence 2:	NP_956757.2	Gene:	maco1b / 393435	ZFINID:	ZDB-GENE-040426-1188	Length:	699	Species:	Danio rerio

Alignment Length:	941	Identity:	326/941 - (34%)
Similarity:	450/941 - (47%)	Gaps:	297/941 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKRRNADCGKLRRPIKRNKITEGMYGSTTVLYMKFLILWAIVMVADFMFMFRFEFLWPFWLLLRS 65
            ||||||||.|||||:|||:||||:||| |.||:|||::||:|::|||:..||||:||||||.:||
Zfish     1 MKRRNADCSKLRRPLKRNRITEGIYGS-TFLYLKFLVVWALVLLADFVLEFRFEYLWPFWLFIRS 64

  Fly    66 VHDSFKYKGLAFSVLFVCIAITSDLVCLFFIPVHWLLFAASTYVWVQYVWHTDKGICLPTIILWM 130
            |:|||:|:||||||.|||:|.|||::||.||||.||.|||||||||||||||::|:||||:.||:
Zfish    65 VYDSFRYQGLAFSVFFVCVAFTSDIICLLFIPVQWLFFAASTYVWVQYVWHTERGVCLPTVSLWI 129

  Fly   131 LFVYLEVGIRWKDSRHMPHLDLCRPFAAHCIGYPVVTLGFGFKSYVGYRMRQRKQREVAKDNEFY 195
            ||||:|..||:||.:|. |:||||||||||||||||||||||||||.|:||.|||:||.|:||||
Zfish   130 LFVYIEAAIRFKDLKHF-HVDLCRPFAAHCIGYPVVTLGFGFKSYVSYKMRLRKQKEVQKENEFY 193

  Fly   196 MQLLQQALPAE---------EAAEEAAAGQAATSSTV-------VVANGSA--------TTPALV 236
            |||||||||.|         ||.|.|||..||.|.::       |..||||        |.|.|.
Zfish   194 MQLLQQALPPEQQLIQRQEREAEEAAAAAAAAASKSIHDVDSPAVAQNGSAGGKKPSSNTLPELE 258

  Fly   237 ASSGATAANGVLATATQAQNHHEHHHSGGAGASSSSSSNSNHHHHHHHNNSSGNSGSNHNSNSSS 301
            ........|    .:.:..||:::|||..:.:...|..|......:..|:.:    |...|:|..
Zfish   259 YREKERGKN----ESKKQHNHNQNHHSSTSSSILPSVDNKAQEMEYMENHVN----SKRLSSSDL 315

  Fly   302 GGAKDNSTSESASGAAASSITASSATGAALAAAASASSASTTSGSSSSSASTGKQSSSSAASAAT 366
            .|:.:|...:                                ..|||||:||...|:.:..:|:.
Zfish   316 LGSTENLLKD--------------------------------EHSSSSSSSTSSNSNKNYKNASG 348

  Fly   367 TGAATTSSTPVSDFSALAASLATQQQQHQSVATAYPATSSARSSSSTSEGVDADGCCGATSNGHA 431
            .|....||:|               :.|.:...:.|::|...||:|:|
Zfish   349 GGGGGGSSSP---------------RGHGTANGSVPSSSGPSSSASSS----------------- 381

  Fly   432 GGSRNHRRSMDKDKHRNKGDAADNEHNNGTRHGGKNSGNNQVDSAATATATVTATSSNSKDKDKE 496
                            :||   |.:...|   |||||.:
Zfish   382 ----------------SKG---DRKQKYG---GGKNSAS-------------------------- 398

  Fly   497 KSDWDSSTSYPQQQQQGGKEKHEKKAGNAVPNGNANHLEDETASVEPTPPVEKATKGRRNRGKKD 561
                                 |.....|.:||
Zfish   399 ---------------------HRDPVENCIPN--------------------------------- 409

  Fly   562 NAAKDNHSHQQQLAQQQKEKDKENTANNNNNDASSVSSSASSTSSNAIANLASKVVSKICETCLK 626
                                                             |..||.     |..::
Zfish   410 -------------------------------------------------NQLSKP-----EALVR 420

  Fly   627 LEADVKKYRAEISHMKQIENELRQKLDANLTSKSTLQAK----QKECDDLEKRIQELNNARHADM 687
            ||.||||.:|::...:|.|.:||.:|.:..||:.:::::    ::|.:.|:.::.....|:..|.
Zfish   421 LEQDVKKLKADLQASRQTEQDLRSQLGSLGTSERSIRSELGQLRQENELLQNKLHNAVQAKQKDK 485

  Fly   688 LNLQTVERRLNEERRQKQSLDSQLSNEKKARKLAEEKAARP---------ECSSQCKQRRQQMDE 743
            ..|..:|:||..|:..:.:.:..|:.|||.:||.|..|||.         ||:...::|..:::.
Zfish   486 QTLGQLEKRLKAEQEARAAAEKLLAEEKKRKKLEEATAARAVALAAATRGECTESLRRRISELEA 550

  Fly   744 EQKRLRSDLKQAEEAKQLAVEHGRKVEQEYRMLEAK---LRNRESSQPDPEILLNALAAMQDKNA 805
            |.|:|..|:|..|:              :.|.||.|   |...:.::.|.|:|::||:|||||..
Zfish   551 ECKKLTLDIKVKED--------------QIRELELKVQELHKYKENEKDTEVLMSALSAMQDKTQ 601

  Fly   806 TLEKNLSAETRVKLDLFSALGAAKRQIEISDNHRRSKEDEVIDLKAKIAQLLAVMPDNL-CMNTG 869
            .||.:||||||:|||||||||.||||:||:......|:.|:.|||.|||:::||||..: ..:||
Zfish   602 HLENSLSAETRIKLDLFSALGDAKRQLEIAQGQILQKDQEIKDLKQKIAEVMAVMPSVVYSADTG 666

  Fly   870 ------PHGPSSSILRMNDTPPLQSGPGPSS 894
                  ||..|    :..||.|  ||..|::
Zfish   667 SMTPVTPHYSS----KFMDTSP--SGLDPNA 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30389	NP_001261116.1	Macoilin	2..893	CDD:286769	324/937 (35%)
		Ax_dynein_light	<624..711	CDD:287215	23/90 (26%)
		RILP-like	<696..803	CDD:304877	35/118 (30%)
maco1b	NP_956757.2	Macoilin	2..697	CDD:286769	325/940 (35%)
		CarR_dom_SF	29..113	CDD:274590	59/83 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..289		20/73 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..411		33/303 (11%)
		TolA_bind_tri	421..>484	CDD:292947	17/62 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	432..451		5/18 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	679..699		6/15 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588387
Domainoid	1	1.000	383	1.000	Domainoid score	I783
eggNOG	1	0.900	-	-		E1_KOG1821
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	325	1.000	Inparanoid score	I2465
OMA	1	1.010	-	-		QHG46421
OrthoDB	1	1.010	-	-		D1227984at2759
OrthoFinder	1	1.000	-	-		FOG0004783
OrthoInspector	1	1.000	-	-		otm24375
orthoMCL	1	0.900	-	-		OOG6_107355
Panther	1	1.100	-	-	O	PTHR13289
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3622
SonicParanoid	1	1.000	-	-		X4642
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800