DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30389 and maco1a

DIOPT Version :9

Sequence 1:	NP_001261116.1	Gene:	CG30389 / 37410	FlyBaseID:	FBgn0050389	Length:	1037	Species:	Drosophila melanogaster
Sequence 2:	NP_956613.2	Gene:	maco1a / 393289	ZFINID:	ZDB-GENE-040426-1097	Length:	664	Species:	Danio rerio

Alignment Length:	941	Identity:	308/941 - (32%)
Similarity:	418/941 - (44%)	Gaps:	332/941 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKRRNADCGKLRRPIKRNKITEGMYGSTTVLYMKFLILWAIVMVADFMFMFRFEFLWPFWLLLRS 65
            ||||||||.|||||:|||:||||:: |:|.||:|||::||:|::|||:..||||:||||||.:||
Zfish     1 MKRRNADCSKLRRPLKRNRITEGIH-SSTFLYLKFLVVWALVLLADFVLEFRFEYLWPFWLFIRS 64

  Fly    66 VHDSFKYKGLAFSVLFVCIAITSDLVCLFFIPVHWLLFAASTYVWVQYVWHTDKGICLPTIILWM 130
            |:|||:|:||||||.|||:|.|||::||.|||..||.|||||||||||||||::|:||||:.||:
Zfish    65 VYDSFRYQGLAFSVFFVCVAFTSDIICLLFIPKQWLFFAASTYVWVQYVWHTERGVCLPTVSLWI 129

  Fly   131 LFVYLEVGIRWKDSRHMPHLDLCRPFAAHCIGYPVVTLGFGFKSYVGYRMRQRKQREVAKDNEFY 195
            ||||:|..||:||.:|. |:||||||||||||||||||||||||||.|:||.|||:||.|:||||
Zfish   130 LFVYIEAAIRFKDLKHF-HVDLCRPFAAHCIGYPVVTLGFGFKSYVSYKMRLRKQKEVQKENEFY 193

  Fly   196 MQLLQQALPAE---------EAAEEAAAGQAATSSTVVVANGSATTPALVASSGATAANGVLATA 251
            |||||||||.|         |..|..:.|.:...|.:|..||             ||.|..|..:
Zfish   194 MQLLQQALPPEQQMLQRQERETEEATSKGMSEADSVLVAQNG-------------TAINKKLPIS 245

  Fly   252 TQAQNHHEHHHSGGAGASSSSSSNSNHHHHHHHNNSSGNSGS---------NH----NSNSSSGG 303
            .....:.|      .|..|:.......|....:||......:         ||    ..|:..||
Zfish   246 LPELEYKE------KGKDSAKDKKQQQHSIGINNNILQTVDAKLQDIEYMENHLNAKRLNNELGG 304

  Fly   304 AKDNSTSESASGAAASSITASSATGAALAAAASASSASTTSGSSSSSASTGKQSSSSAASAATTG 368
            :.:|...:...||                           .|.|:.|
Zfish   305 SAENLFLKEEVGA---------------------------GGGSAPS------------------ 324

  Fly   369 AATTSSTPVSDFSALAASLATQQQQHQSVATAYPATSSARSSSSTSEGVDADGCCGATSNGHAGG 433
                                    :|..       .||.||.:||
Zfish   325 ------------------------KHYK-------NSSPRSHNST-------------------- 338

  Fly   434 SRNHRRSMDKDKHRNKGDAADNEHNNGTRHGGKNSGNNQVDSAATATATVTATSSNSKDKDKEKS 498
                                     ||                     :|.::|||..||
Zfish   339 -------------------------NG---------------------SVPSSSSNRSDK----- 352

  Fly   499 DWDSSTSYPQQQQQGGKE--KHEKKAGNAVPNGNANHLEDETASVEPTPPVEKATKGRRNRGKKD 561
                      :|:..||.  .|.....|.:||   |.|....|.|
Zfish   353 ----------KQKCTGKNLAPHRDLMENCIPN---NQLSKPDALV-------------------- 384

  Fly   562 NAAKDNHSHQQQLAQQQKEKDKENTANNNNNDASSVSSSASSTSSNAIANLASKVVSKICETCLK 626
                                                                            :
Zfish   385 ----------------------------------------------------------------R 385

  Fly   627 LEADVKKYRAEISHMKQIENELRQKL----DANLTSKSTLQAKQKECDDLEKRIQELNNARHADM 687
            ||.|:||.:|::...:|:|.:||.::    .|..:.:|.|...::|.:.|:.::.....|:..|.
Zfish   386 LEQDIKKLKADLQASRQVEQDLRSQISSLSSAERSMRSELGQLRQENELLQNKLHNAVQAKQKDK 450

  Fly   688 LNLQTVERRLNEERRQKQSLDSQLSNEKKARKLAEEKAARP---------ECSSQCKQRRQQMDE 743
            ..:..:|:||..|:..:.:::.||:.|||.:|:.|..|||.         ||:...|.|.::::.
Zfish   451 QTIVQLEKRLKAEQEARAAVEKQLAEEKKRKKMEEATAARAVALAAASRGECTDSLKSRIRELES 515

  Fly   744 EQKRLRSDLKQAEEAKQLAVEHGRKVEQEYRMLEAK---LRNRESSQPDPEILLNALAAMQDKNA 805
            |.|:|..|:|..||              :.|.||.|   |...:.::.|.|:|::||:|||||..
Zfish   516 ECKKLTHDMKLKEE--------------QIRELELKAQELHKYKENEKDTEVLMSALSAMQDKTQ 566

  Fly   806 TLEKNLSAETRVKLDLFSALGAAKRQIEISDNHRRSKEDEVIDLKAKIAQLLAVMP--------D 862
            .||.:||||||:|||||||||.||||:||:......||.|:.:||.|||:::||||        :
Zfish   567 HLENSLSAETRIKLDLFSALGDAKRQLEIAQGQILQKEQEIKELKQKIAEVMAVMPSITYSAETN 631

  Fly   863 NLCMNTGPHGPSSSILRMNDTPPLQSGPGPS 893
            |:...| ||..|    :..||.|....|..|
Zfish   632 NMTPVT-PHYSS----KFMDTSPSSLDPNAS 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30389	NP_001261116.1	Macoilin	2..893	CDD:286769	306/938 (33%)
		Ax_dynein_light	<624..711	CDD:287215	21/90 (23%)
		RILP-like	<696..803	CDD:304877	37/118 (31%)
maco1a	NP_956613.2	Macoilin	2..662	CDD:286769	307/940 (33%)
		DUF4118	31..114	CDD:290228	58/82 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..225		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	315..364		23/205 (11%)
		TolA_bind_tri	386..462	CDD:292947	20/75 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	644..664		5/14 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588386
Domainoid	1	1.000	383	1.000	Domainoid score	I783
eggNOG	1	0.900	-	-		E1_KOG1821
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14449
Inparanoid	1	1.050	325	1.000	Inparanoid score	I2465
OMA	1	1.010	-	-		QHG46421
OrthoDB	1	1.010	-	-		D1227984at2759
OrthoFinder	1	1.000	-	-		FOG0004783
OrthoInspector	1	1.000	-	-		otm24375
orthoMCL	1	0.900	-	-		OOG6_107355
Panther	1	1.100	-	-	LDO	PTHR13289
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3622
SonicParanoid	1	1.000	-	-		X4642
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800