DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30389 and Maco1

DIOPT Version :9

Sequence 1:	NP_001261116.1	Gene:	CG30389 / 37410	FlyBaseID:	FBgn0050389	Length:	1037	Species:	Drosophila melanogaster
Sequence 2:	NP_001020870.2	Gene:	Maco1 / 313618	RGDID:	1561685	Length:	664	Species:	Rattus norvegicus

Alignment Length:	938	Identity:	306/938 - (32%)
Similarity:	428/938 - (45%)	Gaps:	326/938 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKRRNADCGKLRRPIKRNKITEGMYGSTTVLYMKFLILWAIVMVADFMFMFRFEFLWPFWLLLRS 65
            ||||||||.|||||:|||:||||:||| |.||:|||::||:|::|||:..||||:||||||.:||
  Rat     1 MKRRNADCSKLRRPLKRNRITEGIYGS-TFLYLKFLVVWALVLLADFVLEFRFEYLWPFWLFIRS 64

  Fly    66 VHDSFKYKGLAFSVLFVCIAITSDLVCLFFIPVHWLLFAASTYVWVQYVWHTDKGICLPTIILWM 130
            |:|||:|:||||||.|||:|.||:::||.|||:.||.|||||||||||||||::|:||||:.||:
  Rat    65 VYDSFRYQGLAFSVFFVCVAFTSNIICLLFIPIQWLFFAASTYVWVQYVWHTERGVCLPTVSLWI 129

  Fly   131 LFVYLEVGIRWKDSRHMPHLDLCRPFAAHCIGYPVVTLGFGFKSYVGYRMRQRKQREVAKDNEFY 195
            ||||:|..||:||.::. |:||||||||||||||||||||||||||.|:||.|||:||.|:||||
  Rat   130 LFVYIEAAIRFKDLKNF-HVDLCRPFAAHCIGYPVVTLGFGFKSYVSYKMRLRKQKEVQKENEFY 193

  Fly   196 MQLLQQALPAEE--------AAEEAAAGQAATSSTVVVANGSATTPALVASSGATAANGVLATAT 252
            |||||||||.|:        .|||||.|.....|::           |:..:|...||..|:||.
  Rat   194 MQLLQQALPPEQQMLQKQEKEAEEAAKGLPDMDSSI-----------LIHHNGGIPANKKLSTAL 247

  Fly   253 QAQNHHEHHHSGGAGASSSSSSNSNHH-------------HHHHHNNSSGNSGSNHNSNSSSGGA 304
            ....:.|........|...:...:|::             :..:|.||.       ..|:...|:
  Rat   248 PEIEYREKGKEKDKDAKKHNLGINNNNILQPVDSKIQEIEYMENHINSK-------RLNNVLVGS 305

  Fly   305 KDNSTSESASGAAASSITASSATGAALAAAASASSASTTSGSSSSSASTGKQSSSSAASAATTGA 369
            .:|...|.                            |.|:.|.:...::|..:||..:.:||.|:
  Rat   306 TENLLKED----------------------------SCTASSKNYKNASGVVNSSPRSHSATNGS 342

  Fly   370 ATTSSTPVSDFSALAASLATQQQQHQSVATAYPATSSARSSSSTSEGVDADGCCGATSNGHAGGS 434
            ..:||                                                           |
  Rat   343 IPSSS-----------------------------------------------------------S 348

  Fly   435 RNHRRSMDKDKHRNKGDAADNEHNNGTRHGGKNSGNNQVDSAATATATVTATSSNSKDKDKEKSD 499
            :|.:    |.:..:||.:|
  Rat   349 KNEK----KQRCTSKGPSA---------------------------------------------- 363

  Fly   500 WDSSTSYPQQQQQGGKEKHEKKAGNAVPNGNANHLEDETASVEPTPPVEKATKGRRNRGKKDNAA 564
                              |:....|.:||   |.|....|.|
  Rat   364 ------------------HKDLMENCIPN---NQLSKPDALV----------------------- 384

  Fly   565 KDNHSHQQQLAQQQKEKDKENTANNNNNDASSVSSSASSTSSNAIANLASKVVSKICETCLKLEA 629
                                                                         :||.
  Rat   385 -------------------------------------------------------------RLEQ 388

  Fly   630 DVKKYRAEISHMKQIENELRQKLDANLTS-----KSTLQAKQKECDDLEKRIQELNNARHADMLN 689
            |:||.:|::...:|:|.|||.:: ::|:|     :|.:...::|.:.|:.::......:..|..|
  Rat   389 DIKKLKADLQASRQVEQELRSQI-SSLSSTERGIRSEMGQLRQENELLQNKLHNAVQMKQKDKQN 452

  Fly   690 LQTVERRLNEERRQKQSLDSQLSNEKKARKLAEEKAARP---------ECSSQCKQRRQQMDEEQ 745
            :..:|:||..|:..:..::.||..|||.:||.|..|||.         ||:...:.|.::::.|.
  Rat   453 ISQLEKRLKAEQEARGFVEKQLMEEKKRKKLEEATAARAVAFAAASRGECTETLRSRIRELEAEG 517

  Fly   746 KRLRSDLKQAEEAKQLAVEHGRKVEQEYRMLEAK---LRNRESSQPDPEILLNALAAMQDKNATL 807
            |:|..|||..||              :.|.||.|   ||..:.::.|.|:|::||:|||||...|
  Rat   518 KKLTMDLKVKEE--------------QIRELELKVQELRKYKENEKDTEVLMSALSAMQDKTQHL 568

  Fly   808 EKNLSAETRVKLDLFSALGAAKRQIEISDNHRRSKEDEVIDLKAKIAQLLAVMPD-NLCMNTGPH 871
            |.:||||||:|||||||||.||||:||:......|:.|:.|||.|||:::||||. .....|.|.
  Rat   569 ENSLSAETRIKLDLFSALGDAKRQLEIAQGQILQKDQEIKDLKQKIAEVMAVMPSITYSAATSPL 633

  Fly   872 GP-----SSSILRMNDTPPLQSGPGPSS 894
            .|     ||..:   :|.|  ||..|::
  Rat   634 SPVSPHYSSKFV---ETSP--SGLDPNA 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30389	NP_001261116.1	Macoilin	2..893	CDD:286769	304/934 (33%)
		Ax_dynein_light	<624..711	CDD:287215	22/91 (24%)
		RILP-like	<696..803	CDD:304877	39/118 (33%)
Maco1	NP_001020870.2	Macoilin	2..662	CDD:286769	305/937 (33%)
		CarR_dom_SF	29..113	CDD:274590	57/83 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..274		3/21 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..375		18/184 (10%)
		TolA_bind_tri	386..462	CDD:292947	21/76 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	630..664		10/32 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346803
Domainoid	1	1.000	358	1.000	Domainoid score	I942
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14449
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46421
OrthoDB	1	1.010	-	-		D1227984at2759
OrthoFinder	1	1.000	-	-		FOG0004783
OrthoInspector	1	1.000	-	-		oto96672
orthoMCL	1	0.900	-	-		OOG6_107355
Panther	1	1.100	-	-	LDO	PTHR13289
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4642
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.860