Protein Alignment KCNA5 and Task7

DIOPT Version :10

• Sequence 1: NP_002225.2
• Gene: KCNA5 / 3741
• HGNCID: 6224
• Length: 613
• Species: Homo sapiens
• Sequence 2: NP_649891.1
• Gene: Task7 / 41125
• FlyBaseID: FBgn0037690
• Length: 340
• Species: Drosophila melanogaster
• Alignment Length: 195
• Identity: 39/195 - (20%)
• Similarity: 71/195 - (36%)
• Gaps: 53/195 - (27%)

Human   410 IFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWA 474
            |.:.::.:.|.:....|....|...|:|     ..:|:.:.|..|:..:. .::|    |:|::.
  Fly   140 IIRRAKRASGARCTDATEMNLMLATGML-----SSIIITTGAAVFSRYEG-WSYF----DSFYYC 194

Human   475 VVTMTTVGYGDM-----------RPITVGGKIVGSLCAIA-GVLTIALPVPVIVSNFNYFYHRET 527
            .||:||:|:||.           :|    |.:..||..|. |:..:|..:.::|..|......:.
  Fly   195 FVTLTTIGFGDYVALQNDQALTNKP----GYVALSLVFILFGLAVVAASINLLVLRFMTMQAEDA 255

Human   528 DHEE-----------PAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSC 581
            ..:|           |....:|......|..|:...                |.||.::|...||
  Fly   256 KRDEQDAQNLAGNAQPVTFDDESTYNMHGKLLENNY----------------TTENDETASLCSC 304

Human   582  581
              Fly   305  304

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNA5	NP_002225.2	Tetramerization domain. /evidence=ECO:0000305|PubMed:20018952	1..211
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..108
		2 X 11 AA tandem repeat of D-[SP]-G-V-R-P-L-P-P-L-P	61..82
		BTB_POZ	120..246	CDD:453885
		Ion_trans	249..526	CDD:459842	28/127 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..304
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	418..431		2/12 (17%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	480..485		2/4 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	532..559		4/26 (15%)
		PDZ-binding. /evidence=ECO:0000250	611..613
Task7	NP_649891.1	Ion_trans_2	<74..133	CDD:462301
		Ion_trans_2	166..244	CDD:462301	21/91 (23%)