Protein Alignment KCNA5 and Shab

DIOPT Version :10

• Sequence 1: NP_002225.2
• Gene: KCNA5 / 3741
• HGNCID: 6224
• Length: 613
• Species: Homo sapiens
• Sequence 2: NP_001189037.1
• Gene: Shab / 38352
• FlyBaseID: FBgn0262593
• Length: 1607
• Species: Drosophila melanogaster
• Alignment Length: 673
• Identity: 212/673 - (31%)
• Similarity: 306/673 - (45%)
• Gaps: 173/673 - (25%)

Human    13 AMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDADSGVRPLP-PLPDPGVR 76
            |..|..|..|.||.|.:..|.   ...||...|....:..|.||   |...||..| |:..| ..
  Fly   181 AGAVGSGAGAGAGAGASVTGS---GSGAGTGTGTGAGSGSGSGA---AGKEVRYAPFPVASP-TH 238

Human    77 PLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQAL-GTASLHHQ-------------------- 120
            .:|...:::          ....|..|:|....|:: |....|.|
  Fly   239 SIPTTSQQI----------VGSVGGVGVGGASSQSISGGVPTHSQSNTTGALQRTHSRSMSSIPP 293

Human   121 --------------RVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRY-------------FDP 158
                          ||.||:.|:|.|....||.:.|:|.||    |||.             :..
  Fly   294 PEPFMIAQSKAVNSRVSINVGGVRHEVLWRTLERLPHTRLG----RLRECTTHEAIVELCDDYSL 354

Human   159 LRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEI----------------RFYQLGD 207
            ..|||||||:..||..||.:|:: |:|.....:.:..|:|::                :::|..:
  Fly   355 ADNEYFFDRHPKSFSSILNFYRT-GKLHIVDEMCVLAFSDDLEYWGVDELYLESCCQHKYHQRKE 418

Human   208 EAMERFR-EDEGFIKEEEKPLPRN---EFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFC 268
            ...|..| |.|...:.:|:.....   |:|:.:|.:.|.|.:|.:||.||::|:|.|::|.|...
  Fly   419 NVHEEMRKEAESLRQRDEEEFGEGKCAEYQKYLWELLEKPNTSFAARVIAVISILFIVLSTIALT 483

Human   269 LETLPEFRDERELLRHPPAPHQPPAPAPGANGSGVMAPPSGPTVAPLLPRTLADPFFIVETTCVI 333
            |.|||:       |:|..            ||:    |...|.:|            :||..|:.
  Fly   484 LNTLPQ-------LQHID------------NGT----PQDNPQLA------------MVEAVCIT 513

Human   334 WFTFELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAI 398
            |||.|.::||.|.|.|..|.:..:||||::||.|||::|  .|.|.........|:.::     :
  Fly   514 WFTLEYILRFSASPDKWKFFKGGLNIIDLLAILPYFVSL--FLLETNKNATDQFQDVRR-----V 571

Human   399 LRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTH 463
            ::|.|::|:.||.||:|||.|||.||.||:.|.:|||||:.||.:||::|||..||||.|.:.|.
  Fly   572 VQVFRIMRILRILKLARHSTGLQSLGFTLRNSYKELGLLMLFLAMGVLIFSSLAYFAEKDEKDTK 636

Human   464 FSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETD 528
            |.|||:.||||.:|||||||||:.|.|..||::|::|.|.|||.||||:|:||:||..||..:..
  Fly   637 FVSIPETFWWAGITMTTVGYGDIYPTTALGKVIGTVCCICGVLVIALPIPIIVNNFAEFYKNQMR 701

Human   529 HEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVK---A 590
            .|:  .||..:       .|||.   |..||..||                    ...|:|   |
  Fly   702 REK--ALKRRE-------ALDRA---KREGSIVSF--------------------HHINLKDAFA 734

Human   591 KSNVDLRRSLYALCLDTSRETDL 613
            ||     ..|..:.:||.::|::
  Fly   735 KS-----MDLIDVIVDTGKQTNV 752

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNA5	NP_002225.2	Tetramerization domain. /evidence=ECO:0000305|PubMed:20018952	1..211		61/262 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..108		24/95 (25%)
		2 X 11 AA tandem repeat of D-[SP]-G-V-R-P-L-P-P-L-P	61..82		6/21 (29%)
		BTB_POZ	120..246	CDD:453885	44/192 (23%)
		Ion_trans	249..526	CDD:459842	120/276 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..304		4/21 (19%)
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	418..431		7/12 (58%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	480..485		4/4 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	532..559		6/26 (23%)
		PDZ-binding. /evidence=ECO:0000250	611..613		1/1 (100%)
Shab	NP_001189037.1	BTB_POZ_Shab-like	306..414	CDD:349720	32/112 (29%)
		Ion_trans	464..700	CDD:459842	120/277 (43%)