DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCNA5 and KCNQ

DIOPT Version :10

Sequence 1:NP_002225.2 Gene:KCNA5 / 3741 HGNCID:6224 Length:613 Species:Homo sapiens
Sequence 2:NP_788300.3 Gene:KCNQ / 36071 FlyBaseID:FBgn0033494 Length:993 Species:Drosophila melanogaster


Alignment Length:387 Identity:93/387 - (24%)
Similarity:147/387 - (37%) Gaps:115/387 - (29%)


- Green bases have known domain annotations that are detailed below.


Human   157 DPLRNEY-FFD---------RNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAME 211
            ||..:.| |:|         ..||:.:.||....|  .|.:|:|            |..|.....
  Fly     2 DPDNDIYAFYDIRGYKGKCRPGRPNSERILQPRMS--LLGKPLN------------YNRGTRRDV 52

Human   212 RFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCL-----ET 271
            |:|                ..|.:::...|.|      |.:..:...|::..::..||     .|
  Fly    53 RYR----------------RLQSRLYNFLERP------RGLHAIFYHVMVFLMVFTCLALSVFST 95

Human   272 LPEFRDERELLRHPPAPHQPPAPAPGANGSGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFT 336
            :.|:.::...:                                         .|.:|...|||||
  Fly    96 IKEYEEDAVYI-----------------------------------------LFRMEILVVIWFT 119

Human   337 FELLVRFFA---------CPSKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGGGQNGQQ 392
            .|...|.::         |..:..|.:....|||:|.|....:.||.            |.:| |
  Fly   120 MEFGARLWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILASIVVLGM------------GTSG-Q 171

Human   393 AMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEA 457
            ..:.:.||.:|..::.|:.::.|.....::||..:.|..:||...::..|:|:|..|..||..|.
  Fly   172 VFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIFASFLVYMWEK 236

Human   458 DNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNF 519
            | ....||:...|.||.|:|:.|||||||.|||..||::.|.||:.|:...|||..::.|.|
  Fly   237 D-VNDKFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAGILGSGF 297

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNA5NP_002225.2 Tetramerization domain. /evidence=ECO:0000305|PubMed:20018952 1..211 15/63 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..108
2 X 11 AA tandem repeat of D-[SP]-G-V-R-P-L-P-P-L-P 61..82
BTB_POZ 120..246 CDD:453885 20/98 (20%)
Ion_trans 249..526 CDD:459842 73/285 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 282..304 0/21 (0%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 418..431 3/12 (25%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 480..485 4/4 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 532..559
PDZ-binding. /evidence=ECO:0000250 611..613
KCNQNP_788300.3 Ion_trans 72..305 CDD:459842 72/281 (26%)
KCNQ_channel <619..719 CDD:460954
Blue background indicates that the domain is not in the aligned region.

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