DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCNA5 and Shaw

DIOPT Version :10

Sequence 1:NP_002225.2 Gene:KCNA5 / 3741 HGNCID:6224 Length:613 Species:Homo sapiens
Sequence 2:NP_001137782.1 Gene:Shaw / 33599 FlyBaseID:FBgn0003386 Length:619 Species:Drosophila melanogaster


Alignment Length:516 Identity:185/516 - (35%)
Similarity:267/516 - (51%) Gaps:81/516 - (15%)


- Green bases have known domain annotations that are detailed below.


Human   121 RVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRL 185
            ||.:|:.|:|.||...||.:.|.|.|....:.|..:||:.|||||||:...|..:|.||:: |:|
  Fly    26 RVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVLNYYRT-GKL 89

Human   186 RRPVNVSLDVFADEIRFYQLGDEAME--------RFREDEGFI-----------KEEEKPLPR-- 229
            ..|.:|...:|.:|:.|:.|....:|        :.|:.:..:           |..|:.|.|  
  Fly    90 HYPTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETLAVLDRLDLDTEKPSEEELARKF 154

Human   230 --------------NEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERE 280
                          .|.:.::|.:|:.|.||.:|:.|.:|||..|.|||::|||:|.|:      
  Fly   155 GFEEDYYKGTISWWQEMKPRIWSLFDEPYSSNAAKTIGVVSVFFICISILSFCLKTHPD------ 213

Human   281 LLRHPPAPHQPPAPAPGANGSGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFA 345
             :|.|...:.....|.|:||..:....:...:|          ||.:|..|..|||||:||||.:
  Fly   214 -MRVPIVRNITVKTANGSNGWFLDKTQTNAHIA----------FFYIECVCNAWFTFEILVRFIS 267

Human   346 CPSKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRI 410
            .|:|..|.::.:||||.:|...::|.|..:            :......:..||....::|:.|:
  Fly   268 SPNKWEFIKSSVNIIDYIATLSFYIDLVLQ------------RFASHLENADILEFFSIIRIMRL 320

Human   411 FKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTH--FSSIPDAFWW 473
            |||:|||.||:||.:|.:||.:||.||:|||.:|:::|:|.||:||......|  |:|||...||
  Fly   321 FKLTRHSSGLKILIQTFRASAKELTLLVFFLVLGIVIFASLVYYAERIQPNPHNDFNSIPLGLWW 385

Human   474 AVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY-HRETDHEEP----A 533
            |:|||||||||||.|.|..|..||:|||:|||||||||||||||||..:| |.:...:.|    .
  Fly   386 ALVTMTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVSNFAMYYSHTQARAKLPKKRRR 450

Human   534 VLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNV 594
            ||..||..|.:.||...||         |.|...|:..::.....|.....:.|.|.|..|
  Fly   451 VLPVEQPRQPRLPGAPGGV---------SGCGTPGSGPHSGPMGSGGTGPRRMNNKTKDLV 502

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNA5NP_002225.2 Tetramerization domain. /evidence=ECO:0000305|PubMed:20018952 1..211 34/89 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..108
2 X 11 AA tandem repeat of D-[SP]-G-V-R-P-L-P-P-L-P 61..82
BTB_POZ 120..246 CDD:453885 44/159 (28%)
Ion_trans 249..526 CDD:459842 121/279 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 282..304 6/21 (29%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 418..431 6/12 (50%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 480..485 4/4 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 532..559 10/30 (33%)
PDZ-binding. /evidence=ECO:0000250 611..613
ShawNP_001137782.1 BTB_Shaw-like 24..135 CDD:349723 36/109 (33%)
Ion_trans 188..439 CDD:459842 121/279 (43%)
PRK14959 <418..>585 CDD:184923 34/94 (36%)
Blue background indicates that the domain is not in the aligned region.

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