DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCNA5 and Sh

DIOPT Version :10

Sequence 1:NP_002225.2 Gene:KCNA5 / 3741 HGNCID:6224 Length:613 Species:Homo sapiens
Sequence 2:NP_728123.1 Gene:Sh / 32780 FlyBaseID:FBgn0003380 Length:655 Species:Drosophila melanogaster


Alignment Length:458 Identity:300/458 - (65%)
Similarity:348/458 - (75%) Gaps:45/458 - (9%)


- Green bases have known domain annotations that are detailed below.


Human    91 PPPEDEEEEGDPGLGTVEDQALGTASLHH----------QRVHINISGLRFETQLGTLAQFPNTL 145
            |....::|||..|.|      .|....|.          :||.||:|||||||||.||.|||:||
  Fly    64 PKLSSQDEEGGAGHG------FGGGPQHFEPIPHDHDFCERVVINVSGLRFETQLRTLNQFPDTL 122

Human   146 LGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAM 210
            |||||:||||||||||||||||:|||||.|||||||||||||||||.||||::||:||:|||:|:
  Fly   123 LGDPARRLRYFDPLRNEYFFDRSRPSFDAILYYYQSGGRLRRPVNVPLDVFSEEIKFYELGDQAI 187

Human   211 ERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEF 275
            .:||||||||||||:|||.||.||:|||:|||||||.:||.:||:||.|||:||:.|||||||||
  Fly   188 NKFREDEGFIKEEERPLPDNEKQRKVWLLFEYPESSQAARVVAIISVFVILLSIVIFCLETLPEF 252

Human   276 RDERELLRHPPAPHQPPAPAPGANGSGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELL 340
            :..:..             ....||:.:....        :| .:.||||::||.|:|||||||.
  Fly   253 KHYKVF-------------NTTTNGTKIEEDE--------VP-DITDPFFLIETLCIIWFTFELT 295

Human   341 VRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQ-----PGGGGGGQ--NGQQAMSLAI 398
            |||.|||:|..|.|::||:||::||.||||||.|.:||::     |......|  :..|||||||
  Fly   296 VRFLACPNKLNFCRDVMNVIDIIAIIPYFITLATVVAEEEDTLNLPKAPVSPQDKSSNQAMSLAI 360

Human   399 LRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTH 463
            ||||||||||||||||||||||||||:||:|||||||||||||||||:|||||||||||.::.:.
  Fly   361 LRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFIGVVLFSSAVYFAEAGSENSF 425

Human   464 FSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETD 528
            |.|||||||||||||||||||||.|:.|.||||||||||||||||||||||||||||||||||||
  Fly   426 FKSIPDAFWWAVVTMTTVGYGDMTPVGVWGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETD 490

Human   529 HEE 531
            .||
  Fly   491 QEE 493

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNA5NP_002225.2 Tetramerization domain. /evidence=ECO:0000305|PubMed:20018952 1..211 83/129 (64%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..108 6/16 (38%)
2 X 11 AA tandem repeat of D-[SP]-G-V-R-P-L-P-P-L-P 61..82
BTB_POZ 120..246 CDD:453885 102/125 (82%)
Ion_trans 249..526 CDD:459842 182/283 (64%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 282..304 2/21 (10%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 418..431 10/12 (83%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 480..485 4/4 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 532..559 300/458 (66%)
PDZ-binding. /evidence=ECO:0000250 611..613
ShNP_728123.1 BTB_POZ 97..223 CDD:453885 102/125 (82%)
Ion_trans 226..488 CDD:459842 182/283 (64%)
Blue background indicates that the domain is not in the aligned region.

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