DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCNA5 and RpL37-1

DIOPT Version :10

Sequence 1:NP_002225.2 Gene:KCNA5 / 3741 HGNCID:6224 Length:613 Species:Homo sapiens
Sequence 2:NP_573005.1 Gene:RpL37-1 / 32446 FlyBaseID:FBgn0030616 Length:93 Species:Drosophila melanogaster


Alignment Length:50 Identity:14/50 - (28%)
Similarity:20/50 - (40%) Gaps:10/50 - (20%)


- Green bases have known domain annotations that are detailed below.


Human   113 GTASL--HHQRVHI---NISGLRFETQLGTLAQFPNTLLGDPAKRLRYFD 157
            ||:|.  .|.:.|.   ......:..|..|.||     .|.||.:||.::
  Fly     4 GTSSFGKRHNKTHTLCRRCGRSSYHIQKSTCAQ-----CGYPAAKLRSYN 48

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNA5NP_002225.2 Tetramerization domain. /evidence=ECO:0000305|PubMed:20018952 1..211 14/49 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..108
2 X 11 AA tandem repeat of D-[SP]-G-V-R-P-L-P-P-L-P 61..82
BTB_POZ 120..246 CDD:453885 10/40 (25%)
Ion_trans 249..526 CDD:459842
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 282..304
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 418..431
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 480..485
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 532..559
PDZ-binding. /evidence=ECO:0000250 611..613
RpL37-1NP_573005.1 PTZ00073 1..91 CDD:240257 14/49 (29%)
Blue background indicates that the domain is not in the aligned region.

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