Protein Alignment Hmg-2 and SOX13

DIOPT Version :10

• Sequence 1: NP_611553.1
• Gene: Hmg-2 / 37407
• FlyBaseID: FBgn0026582
• Length: 376
• Species: Drosophila melanogaster
• Sequence 2: NP_005677.2
• Gene: SOX13 / 9580
• HGNCID: 11192
• Length: 622
• Species: Homo sapiens
• Alignment Length: 372
• Identity: 69/372 - (18%)
• Similarity: 123/372 - (33%)
• Gaps: 130/372 - (34%)

  Fly     2 TEPTSKTPDAVP-------------ESPVSLPIASQSMDTATIEDFDEDKPAKGKKKAKNPKGRH 53
            :.|:.|....||             .||.|||:....         :.|...|..:.|:.....|
Human   309 SSPSLKMSSCVPRPPSHGGPTRDLQSSPPSLPLGFLG---------EGDAVTKAIQDARQLLHSH 364

  Fly    54 SDSDIGSELKKLAQRRINVAGAP-------------------------------------KMPLN 81
            |.:..||......:..|::..:|                                     |.|:|
Human   365 SGALDGSPNTPFRKDLISLDSSPAKERLEDGCVHPLEEAMLSCDMDGSRHFPESRNSSHIKRPMN 429

  Fly    82 GYVRFMNDRREELRREQPQRTALEHTRIIGEEWHQLPEERKLPYIEAAAKDKAIYQEQLQM---F 143
            .::.:..|.|.::.:..|.......::|:|..|..:..:.|.||          |:||.::   .
Human   430 AFMVWAKDERRKILQAFPDMHNSSISKILGSRWKSMTNQEKQPY----------YEEQARLSRQH 484

  Fly   144 LKEHPEIVANELAKAKKATKLDGSPKEKTPKGE-SALGKAKKTKAKPVKRQSEDPDDVPLAKVKR 207
            |:::|:.  ....:.|:...::|   ::...|| .||.:.::..|    |||.   .:|
Human   485 LEKYPDY--KYKPRPKRTCIVEG---KRLRVGEYKALMRTRRQDA----RQSY---VIP------ 531

  Fly   208 AQTPPPPTPPAAPVQ--------PPPSSVPPATP-----APRPLQPGEIPIYTNEFIEHNRSTEN 259
                    |.|..||        |..:.:|.|.|     .||.|.| .:|:..|..
Human   532 --------PQAGQVQMSSSDVLYPRAAGMPLAQPLVEHYVPRSLDP-NMPVIVNTC--------- 578

  Fly   260 ELRTLRKAKTDLEQQNAVLEQHV-----DNTKAGYAKVMGEVTELME 301
               :||:.....:.:::|.:..:     |....|..|..||:..|.:
Human   579 ---SLREEGEGTDDRHSVADGEMYRYSEDEDSEGEEKSDGELVVLTD 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hmg-2	NP_611553.1	HMG-box_HMG20	75..154	CDD:438796	18/118 (15%)
SOX13	NP_005677.2	HMG-box_SoxD	423..499	CDD:438839	17/87 (20%)