DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hmg-2 and UBTFL1

DIOPT Version :9

Sequence 1:	NP_611553.1	Gene:	Hmg-2 / 37407	FlyBaseID:	FBgn0026582	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_001137447.1	Gene:	UBTFL1 / 642623	HGNCID:	14533	Length:	393	Species:	Homo sapiens

Alignment Length:	256	Identity:	63/256 - (24%)
Similarity:	104/256 - (40%)	Gaps:	59/256 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 LKKL--AQRRINVAGAPKMPLNGYVRFMNDRREELRREQPQRTALEHTRIIGEEWHQLPEERKLP 124
            :||:  :|:..|....||.||..|.||..:...:..:..|...:.|.|:|:.:::.:|||:.|..
Human    84 VKKMNKSQKYRNGPDFPKRPLTAYNRFFKESWPQYSQMYPGMRSQELTKILSKKYRELPEQMKQK 148

  Fly   125 YIEAAAKDKAIYQEQLQMFLKEHPEIVANELAKAKKATKLDGSPKEKTPKGESALGKAKKTKA-K 188
            ||:...|:|..::|:|..|.:|||::|    .||||                |::.|..:.|. |
Human   149 YIQDFRKEKQEFEEKLARFREEHPDLV----QKAKK----------------SSVSKRTQNKVQK 193

  Fly   189 PVKRQSEDPDDVP-----LAKVKRAQTPPPPTPPAAPVQPPP--------------SSVPPATPA 234
            ..::..|:...:|     ..|||....|          |.||              ..:...:..
Human   194 KFQKNIEEVRSLPKTDRFFKKVKFHGEP----------QKPPMNGYHKFHQDSWSSKEMQHLSVR 248

  Fly   235 PRPLQPG----EIPIYTNEFIEHNRSTENELRTLRKAKTDLEQQNAVLEQHVDNTKAGYAK 291
            .|.::.|    .||   ....:|.:|...||:...|.|.||..:....|.:....::.|||
Human   249 ERMVEIGRRWQRIP---QSQKDHFKSQAEELQKQYKVKLDLWLKTLSPENYAAYKESTYAK 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hmg-2	NP_611553.1	HMGB-UBF_HMG-box	76..141	CDD:238686	20/64 (31%)
UBTFL1	NP_001137447.1	HMGB-UBF_HMG-box	100..165	CDD:238686	20/64 (31%)
		HMGB-UBF_HMG-box	223..285	CDD:238686	12/64 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	308..393
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5648
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810