DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hmg-2 and hmgb3

DIOPT Version :9

Sequence 1:	NP_611553.1	Gene:	Hmg-2 / 37407	FlyBaseID:	FBgn0026582	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_001004888.1	Gene:	hmgb3 / 448228	XenbaseID:	XB-GENE-1002014	Length:	202	Species:	Xenopus tropicalis

Alignment Length:	212	Identity:	50/212 - (23%)
Similarity:	75/212 - (35%)	Gaps:	81/212 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PESPVSLPIAS-------QSMDTATIEDFDE----DK-----------PAKGKKKAKNPKGRHSD 55
            ||.||:....|       ::|.......||:    ||           |.|..||.|:|
Frog    32 PEIPVNFAEFSKKCSERWKTMSAKEKSKFDDLAKADKVRYDREMKDFGPVKKGKKKKDP------ 90

  Fly    56 SDIGSELKKLAQRRINVAGAPKMPLNGYVRFMNDRREELRREQPQRTALEHTRIIGEEWHQLPEE 120
                              .|||.|.:|:..|.::.|.:::...|..:..:..:.:||.|:.|.:.
Frog    91 ------------------NAPKRPPSGFFLFCSEFRPKIKSTNPGISIGDVAKKLGEMWNNLNDG 137

  Fly   121 RKLPYIEAAAKDKAIYQEQLQMFLKEHPEIVANELAKAKKATKLD---GSPKEKTPKGESALGKA 182
            .|.||...|||.|..|::               ::|..|...|.|   |:||           .|
Frog   138 EKQPYNNKAAKLKEKYEK---------------DVADYKSKGKFDCAKGAPK-----------LA 176

  Fly   183 KKTKAKPVKRQSEDPDD 199
            :|      |.:.||.||
Frog   177 RK------KEEDEDDDD 187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hmg-2	NP_611553.1	HMGB-UBF_HMG-box	76..141	CDD:238686	19/64 (30%)
hmgb3	NP_001004888.1	HMG-box	13..78	CDD:381793	10/45 (22%)
hmgb3	NP_001004888.1	HMG_box	93..160	CDD:366139	20/81 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3288
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940