DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hmg-2 and hmgb1

DIOPT Version :9

Sequence 1:	NP_611553.1	Gene:	Hmg-2 / 37407	FlyBaseID:	FBgn0026582	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_989226.1	Gene:	hmgb1 / 394834	XenbaseID:	XB-GENE-1001206	Length:	211	Species:	Xenopus tropicalis

Alignment Length:	163	Identity:	45/163 - (27%)
Similarity:	63/163 - (38%)	Gaps:	51/163 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 PAKG--KKKAKNPKGRHSDSDIGSELKKLAQRRINVAGAPKMPLNGYVRFMNDRREELRREQPQR 101
            |.||  |||.|:|                        .|||.|.:.:..|.::.|.:::.|.|..
Frog    80 PPKGETKKKFKDP------------------------NAPKRPPSAFFLFCSEFRPKIKGEHPGS 120

  Fly   102 TALEHTRIIGEEWHQLPEERKLPYIEAAAKDKAIYQEQLQMFLKEHPEIVANELAKAKKATKLDG 166
            |..:..:.:||.|:....:.||||...|||.|..|::.           ||...||.|.
Frog   121 TIGDIAKKLGEMWNNTATDDKLPYERKAAKLKEKYEKD-----------VAAYRAKGKP------ 168

  Fly   167 SPKEKTPKGESALGKAKKTKAKPVKRQSEDPDD 199
            .|.:|.|        ||..|||..:...:|.||
Frog   169 EPAKKAP--------AKFEKAKKKEDDDDDEDD 193

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hmg-2	NP_611553.1	HMGB-UBF_HMG-box	76..141	CDD:238686	20/64 (31%)
hmgb1	NP_989226.1	HMG_box_2	6..78	CDD:370242
hmgb1	NP_989226.1	HMG_box	95..162	CDD:366139	22/77 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3288
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940