DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hmg-2 and Hmg20a

DIOPT Version :9

Sequence 1:	NP_611553.1	Gene:	Hmg-2 / 37407	FlyBaseID:	FBgn0026582	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	XP_006243179.1	Gene:	Hmg20a / 315689	RGDID:	1564760	Length:	350	Species:	Rattus norvegicus

Alignment Length:	370	Identity:	97/370 - (26%)
Similarity:	166/370 - (44%)	Gaps:	70/370 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PESPVSLPIASQSMDTATIEDF--------DEDKPAKGKKKAKNPKGRHSDSDIGSELKKLAQRR 69
            ||.|......|.:.:...:||.        :....|:|.:  :.|:........|....:..::.
  Rat    37 PEGPYGSAATSTTNNPEFVEDLSQGQLLQSESSNAAEGSE--QRPEDEQRSKRGGWSKGRKRKKP 99

  Fly    70 INVAGAPKMPLNGYVRFMNDRREELRREQPQRTALEHTRIIGEEWHQLPEERKLPYIEAAAKDKA 134
            :..:.|||.||.|||||||:|||:||.::|:....|.||::|.||.:||.|.|..|::.|.:||.
  Rat   100 LRDSNAPKSPLTGYVRFMNERREQLRAKRPEVPFPEITRMLGNEWSKLPPEEKQRYLDEADRDKE 164

  Fly   135 IYQEQLQMFLKEHPEIVANELAKAKKATKLDGSPKEKTPKGESALGKAKKTKAKPVKRQSEDPDD 199
            .|.::|:.:.|             .:|.|:.....:...||:|....|.:......::::|
  Rat   165 RYMKELEQYQK-------------TEAYKVFSRKTQDRQKGKSHRQDAARQATHDHEKETE---- 212

  Fly   200 VPLAKVKRAQTPPPPTPPAAPVQPPPSSVPPATPAPRPLQPGEIPIYTNEFIEHNRSTENELRTL 264
                 ||....                              .:|||:|.||:.|:::.|.|||.|
  Rat   213 -----VKERSV------------------------------FDIPIFTEEFLNHSKAREAELRQL 242

  Fly   265 RKAKTDLEQQNAVLEQHVDNTKAGYAKVMGEVTELMEENQRLETYLRALRQKLVAALGGISMPPL 329
            ||:..:.|::||.|::||::.:....|:..:|.:....|..|:.:|..|||.|.::...:   ||
  Rat   243 RKSNMEFEERNAALQKHVESMRTAVEKLEVDVIQERSRNTVLQQHLETLRQMLTSSFASM---PL 304

  Fly   330 EPSG--PSVGNIDKYIRHLAGLV---TQPSNVTLIKAREALRKVD 369
            ..||  |:|..||.|:..|..::   .|.:...:...||.:.::|
  Rat   305 PGSGEIPTVDTIDSYMNRLHSIILANPQDNENFIATVREVVNRLD 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hmg-2	NP_611553.1	HMGB-UBF_HMG-box	76..141	CDD:238686	32/64 (50%)
Hmg20a	XP_006243179.1	HMGB-UBF_HMG-box	106..171	CDD:238686	32/64 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	77	1.000	Domainoid score	I8651
eggNOG	1	0.900	-	-		E1_COG5648
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32399
Inparanoid	1	1.050	137	1.000	Inparanoid score	I4447
OMA	1	1.010	-	-		QHG45555
OrthoDB	1	1.010	-	-		D1458939at2759
OrthoFinder	1	1.000	-	-		FOG0003510
OrthoInspector	1	1.000	-	-		otm45337
orthoMCL	1	0.900	-	-		OOG6_106551
Panther	1	1.100	-	-	O	PTHR46040
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2882
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.880