Protein Alignment Hmg-2 and HMGB2

DIOPT Version :9

• Sequence 1: NP_611553.1
• Gene: Hmg-2 / 37407
• FlyBaseID: FBgn0026582
• Length: 376
• Species: Drosophila melanogaster
• Sequence 2: NP_001124160.1
• Gene: HMGB2 / 3148
• HGNCID: 5000
• Length: 209
• Species: Homo sapiens
• Alignment Length: 200
• Identity: 43/200 - (21%)
• Similarity: 82/200 - (41%)
• Gaps: 45/200 - (22%)

  Fly    13 PESPVSLPIASQ----------SMDTATIEDFDEDKPAKGKKKAKN---PKGRHSDSDIGSELKK 64
            |:|.|:....|:          :.:.:..||..:...|:..::.||   |||.          ||
Human    32 PDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKARYDREMKNYVPPKGD----------KK 86

  Fly    65 LAQRRINVAGAPKMPLNGYVRFMNDRREELRREQPQRTALEHTRIIGEEWHQLPEERKLPYIEAA 129
            ..::..|   |||.|.:.:..|.::.|.:::.|.|..:..:..:.:||.|.:...:.|.||.:.|
Human    87 GKKKDPN---APKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKA 148

  Fly   130 AKDKAIYQEQLQMFLKEHPEIVANELAKAKKATKLDGSPKEKTPKGESALGKAKKTKAKPVKRQS 194
            ||.|..|::.:..:..:         .|::...|..|.|          .|..||.:.:..:.:.
Human   149 AKLKEKYEKDIAAYRAK---------GKSEAGKKGPGRP----------TGSKKKNEPEDEEEEE 194

  Fly   195 EDPDD 199
            |:.|:
Human   195 EEEDE 199

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hmg-2	NP_611553.1	HMGB-UBF_HMG-box	76..141	CDD:238686	18/64 (28%)
HMGB2	NP_001124160.1	HMG_box_2	6..78	CDD:401091	8/45 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	52..150		26/110 (24%)
		HMG_box	95..162	CDD:395407	18/66 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	162..209		9/56 (16%)
		Required for chemotactic activity. /evidence=ECO:0000269|PubMed:19811285	165..180		4/33 (12%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5648
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3288
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840