Protein Alignment Hmg-2 and Sox18

DIOPT Version :10

• Sequence 1: NP_611553.1
• Gene: Hmg-2 / 37407
• FlyBaseID: FBgn0026582
• Length: 376
• Species: Drosophila melanogaster
• Sequence 2: NP_001019952.1
• Gene: Sox18 / 311723
• RGDID: 1311718
• Length: 377
• Species: Rattus norvegicus
• Alignment Length: 294
• Identity: 61/294 - (20%)
• Similarity: 99/294 - (33%)
• Gaps: 94/294 - (31%)

  Fly     4 PTSKTPDAVPESPVSLPIASQSMDTATIEDFDEDKPAKGKKKAKNPKGRHSDSDIGSELKKLAQR 68
            |.:......|.||.|||                ..|.:..:..:...||       .|.:...:.
  Rat    36 PVTNVSPTSPASPSSLP----------------RSPPRSPESGRYGFGR-------GERQTADEL 77

  Fly    69 RINVAGAPKMPLNGYVRFMNDRREELRREQPQRTALEHTRIIGEEWHQLPEERKLPYIEAAAKDK 133
            ||      :.|:|.::.:..|.|:.|.::.|.......::::|:.|.:|....|.|::|.|
  Rat    78 RI------RRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNTAEKRPFVEEA---- 132

  Fly   134 AIYQEQLQM-FLKEHPEIVANELAK--AKKATKLDG--------SPKEKTPKGESALGKAKKTKA 187
                |:|:: .|::||........|  |:|..:|:.        .|........:|.|.|:..:.
  Rat   133 ----ERLRVQHLRDHPNYKYRPRRKKQARKVRRLEPGLLLPGLVQPSAPPEPFAAASGSARSFRE 193

  Fly   188 KPVKRQSED------PDDVPLAKVKRAQTP--PPPTPP--------AAPVQP----PPS------ 226
            .|......|      |:..||..::..:..  |||..|        .||..|    .||
  Rat   194 LPTLGAEFDGLGLPTPERSPLDGLESGEASFFPPPLAPEDCALRAFRAPYAPELARDPSFCYGSS 258

  Fly   227 ------SVPPATPA--------------PRPLQP 240
                  :.|||.|.              |.||.|
  Rat   259 LAEALRTAPPAAPLAGLYYGTLGTPGPFPNPLSP 292

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hmg-2	NP_611553.1	HMG-box_HMG20	75..154	CDD:438796	18/79 (23%)
Sox18	NP_001019952.1	HMG-box_SoxF_SOX18	76..155	CDD:438851	21/92 (23%)
		Sox17_18_mid	191..239	CDD:463454	9/47 (19%)