DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hmg-2 and Tox4

DIOPT Version :9

Sequence 1:NP_611553.1 Gene:Hmg-2 / 37407 FlyBaseID:FBgn0026582 Length:376 Species:Drosophila melanogaster
Sequence 2:NP_775446.2 Gene:Tox4 / 286990 RGDID:708449 Length:619 Species:Rattus norvegicus


Alignment Length:352 Identity:76/352 - (21%)
Similarity:129/352 - (36%) Gaps:102/352 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 PDAVPESPVS-LPIASQSMDTATIEDFDEDKPAK-------GKKKAKNPKGRHSDSDIGSELKKL 65
            |...||..:| .|..:.|:....::||....||:       |||: |.||               
  Rat   165 PAQSPEDRLSTTPSPTNSLHEDGVDDFRRQLPAQKTVVVETGKKQ-KAPK--------------- 213

  Fly    66 AQRRINVAGAPKMPLNGYVRFMNDRREELRREQPQRTALEHTRIIGEEWHQLPEERKLPY---IE 127
             :|:......|:.|::.|..|..|.:..::.:.|..|..|.::|:...|..|.||:|..|   .|
  Rat   214 -KRKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTE 277

  Fly   128 AAAKDKAIYQEQLQMFLKEHPEIVANELAKAKKATKLDGSPKEKTPKGESALGKAKKTKAKPVKR 192
            ||.|:   |.:.|..: |::.|..|     ..:..:||..|:.:||.                  
  Rat   278 AAKKE---YLKALAAY-KDNQECQA-----TVETVELDPVPQSQTPS------------------ 315

  Fly   193 QSEDPDDVPLAKVKRAQTPPPPTPPAAPVQPPPSSVPPATPAPRPLQPGEIPIYTNEFIEH---N 254
                               |||...|.|..|.|:|.  .:||..|.      |..|..:..   |
  Rat   316 -------------------PPPVTTADPASPAPAST--ESPALSPC------IVVNSTLSSYVAN 353

  Fly   255 RSTENELRTLRKAKTDLEQQNAVLEQHVDNTKAGYAKV------------MGEV-TELMEENQRL 306
            :::..........|..:.:|  :|...:..::.|...|            :|:. |..::.:|:.
  Rat   354 QASSGPGGQPNITKLIITKQ--MLPSSITMSQGGMVTVIPATVVTSRGLQLGQTSTATIQPSQQA 416

  Fly   307 ETYLRALRQKLVAALGGISMPP--LEP 331
            :...|::.|...||...:.:||  |:|
  Rat   417 QIVTRSVLQAAAAAAASMQLPPPRLQP 443

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hmg-2NP_611553.1 HMGB-UBF_HMG-box 76..141 CDD:238686 20/67 (30%)
Tox4NP_775446.2 NHP6B 140..>306 CDD:227935 41/166 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 155..227 18/78 (23%)
Nuclear localization signal. /evidence=ECO:0000255 213..218 2/20 (10%)
HMG-box 223..288 CDD:238037 20/67 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 304..335 13/69 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 436..458 4/8 (50%)
PHA03160 <464..530 CDD:165431
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5648
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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