DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hmg-2 and TOX3

DIOPT Version :9

Sequence 1:	NP_611553.1	Gene:	Hmg-2 / 37407	FlyBaseID:	FBgn0026582	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_001073899.2	Gene:	TOX3 / 27324	HGNCID:	11972	Length:	576	Species:	Homo sapiens

Alignment Length:	350	Identity:	74/350 - (21%)
Similarity:	129/350 - (36%)	Gaps:	83/350 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TSKTPDAVPESPVSLPIASQSMDTATIEDFDEDKPAKGKKKAKNPKGRHSDSDIGSELKKLAQRR 69
            ||.:|   |.|..:.|..|.|::.   ||.||...|.|:|:|.        .|.|.:.|...:::
Human   198 TSPSP---PASKSATPSPSSSINE---EDADEANRAIGEKRAA--------PDSGKKPKTPKKKK 248

  Fly    70 INVAGAPKMPLNGYVRFMNDRREELRREQPQRTALEHTRIIGEEWHQLPEERKLPYIEAAAKDKA 134
            ......|:.|::.|..|..|.:..::.:.|..|..|.::|:...|..|.||:|..|   ..|.:|
Human   249 KKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVY---KRKTEA 310

  Fly   135 IYQEQLQMFLKEHPEIVANELAKAKKA------------TKLDGSPKEKTPKGESALGKAKKTKA 187
            ..:|.|:........:|:...|::.:|            |.|..|....||     |.:.....|
Human   311 AKKEYLKALAAYRASLVSKAAAESAEAQTIRSVQQTLASTNLTSSLLLNTP-----LSQHGTVSA 370

  Fly   188 KPVKRQSEDPDDVPLAKVKRAQTPPPPTPPAAPVQPPPSSVPPATPAP----RPL-------QPG 241
            .|...|...|..:          .|.|.....|:....:||..|...|    .||       ..|
Human   371 SPQTLQQSLPRSI----------APKPLTMRLPMNQIVTSVTIAANMPSNIGAPLISSMGTTMVG 425

  Fly   242 EIP-------IYTNEFIEHNRSTENELRTLRKAKTDLEQQNAVLEQHVDNTKAGYAKVMGEVTEL 299
            ..|       :.|.   :|....:.:.:..::....::||.  |:||         ::..::.:.
Human   426 SAPSTQVSPSVQTQ---QHQMQLQQQQQQQQQQMQQMQQQQ--LQQH---------QMHQQIQQQ 476

  Fly   300 MEE-------NQRLETYLRALRQKL 317
            |::       .|.|:...:.|:|::
Human   477 MQQQHFQHHMQQHLQQQQQHLQQQI 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hmg-2	NP_611553.1	HMGB-UBF_HMG-box	76..141	CDD:238686	18/64 (28%)
TOX3	NP_001073899.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	189..258		20/73 (27%)
		HMG-box	255..320	CDD:238037	19/67 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..443		4/23 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	519..563
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5648
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810