DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hmg-2 and Tox3

DIOPT Version :9

Sequence 1:	NP_611553.1	Gene:	Hmg-2 / 37407	FlyBaseID:	FBgn0026582	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_766501.2	Gene:	Tox3 / 244579	MGIID:	3039593	Length:	575	Species:	Mus musculus

Alignment Length:	238	Identity:	55/238 - (23%)
Similarity:	98/238 - (41%)	Gaps:	50/238 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SKTPDAVPESPVSLPIASQSMDTATIEDFDEDKPAKGKKKAKNPKGRHSDSDIGSELKKLAQRRI 70
            |.|..:.|.|..:.|..|.|::.   ||.|:...|.|:|:        :..|.|.:.|...:::.
Mouse   195 SHTSPSPPASKSATPSPSSSINE---EDADDANRAIGEKR--------TAPDSGKKPKTPKKKKK 248

  Fly    71 NVAGAPKMPLNGYVRFMNDRREELRREQPQRTALEHTRIIGEEWHQLPEERKLPY---IEAAAKD 132
            .....|:.|::.|..|..|.:..::.:.|..|..|.::|:...|..|.||:|..|   .|||.|:
Mouse   249 KDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKE 313

  Fly   133 KAIYQEQLQMFLKEHPEIVANELAKAKKATKLDGSPKEKTPKGESALGKAKKTKAKPVK--RQSE 195
                      :||......|:.::||                      .|:..:|:.::  :|:.
Mouse   314 ----------YLKALAAYRASLVSKA----------------------AAESAEAQTIRSVQQTL 346

  Fly   196 DPDDVPLAKVKRAQTPPPPTPPAAPVQPPPSSVPPATPAPRPL 238
            ...::..:.:.........|.||:| |..|.|:|.:. ||:||
Mouse   347 ASTNLTSSLLLNTSLSQHGTVPASP-QTLPQSLPRSI-APKPL 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hmg-2	NP_611553.1	HMGB-UBF_HMG-box	76..141	CDD:238686	19/67 (28%)
Tox3	NP_766501.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	189..258		17/73 (23%)
		HMG-box	254..319	CDD:238037	21/74 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	516..575
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5648
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810