DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hmg-2 and Hmgb1

DIOPT Version :10

Sequence 1:NP_611553.1 Gene:Hmg-2 / 37407 FlyBaseID:FBgn0026582 Length:376 Species:Drosophila melanogaster
Sequence 2:NP_034569.1 Gene:Hmgb1 / 15289 MGIID:96113 Length:215 Species:Mus musculus


Alignment Length:207 Identity:48/207 - (23%)
Similarity:89/207 - (42%) Gaps:27/207 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 EPTSKTPDA-VPESPVSLPIASQ-----SMDTATIEDFDEDKPAKGKKKAKN---PKGRHSDSDI 58
            |...|.||| |..|..|...:.:     :.:....||..:...|:.:::.|.   |||       
Mouse    26 EHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKG------- 83

  Fly    59 GSELKKLAQRRINVAGAPKMPLNGYVRFMNDRREELRREQPQRTALEHTRIIGEEWHQLPEERKL 123
              |.||    :.....|||.|.:.:..|.::.|.:::.|.|..:..:..:.:||.|:....:.|.
Mouse    84 --ETKK----KFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQ 142

  Fly   124 PYIEAAAKDKAIYQEQLQMF-LKEHPEIVANELAKAKKATKLDGSPKEKTPKGESALGKAKKTKA 187
            ||.:.|||.|..|::.:..: .|..|:.....:.||:|:.|    .||:....|....:.::.:.
Mouse   143 PYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKK----KKEEEDDEEDEEDEEEEEEE 203

  Fly   188 KPVKRQSEDPDD 199
            :....:.:|.|:
Mouse   204 EDEDEEEDDDDE 215

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hmg-2NP_611553.1 HMG-box_HMG20 75..154 CDD:438796 21/79 (27%)
Hmgb1NP_034569.1 Sufficient for interaction with HAVCR2. /evidence=ECO:0000269|PubMed:22842346 1..97 20/83 (24%)
LPS binding (delipidated). /evidence=ECO:0000250|UniProtKB:P09429 3..15
HMG-box_HMGB_rpt1 8..76 CDD:438794 11/49 (22%)
NLS 1. /evidence=ECO:0000250|UniProtKB:P63159 27..43 6/15 (40%)
Nuclear localization signal (NLS) 1. /evidence=ECO:0000250|UniProtKB:P63159 27..43 6/15 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 76..95 7/31 (23%)
LPS binding (Lipid A). /evidence=ECO:0000250|UniProtKB:P09429 80..96 7/28 (25%)
Cytokine-stimulating activity. /evidence=ECO:0000250|UniProtKB:P09429 89..108 5/18 (28%)
HMG-box_HMGB_rpt2 93..163 CDD:438795 19/69 (28%)
Binding to AGER/RAGE. /evidence=ECO:0000250|UniProtKB:P63159 150..183 8/32 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 161..215 10/57 (18%)
NLS 2. /evidence=ECO:0000250|UniProtKB:P63159 178..184 3/9 (33%)
Nuclear localization signal (NLS) 2. /evidence=ECO:0000250|UniProtKB:P63159 178..184 3/9 (33%)
Blue background indicates that the domain is not in the aligned region.

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