Protein Alignment Hmg-2 and HMG20A

DIOPT Version :10

• Sequence 1: NP_611553.1
• Gene: Hmg-2 / 37407
• FlyBaseID: FBgn0026582
• Length: 376
• Species: Drosophila melanogaster
• Sequence 2: NP_060670.1
• Gene: HMG20A / 10363
• HGNCID: 5001
• Length: 347
• Species: Homo sapiens
• Alignment Length: 368
• Identity: 101/368 - (27%)
• Similarity: 171/368 - (46%)
• Gaps: 66/368 - (17%)

  Fly    13 PESPVSLPIASQSMDTATIEDFDEDK--PAKGKKKAKNPKGRHSD---SDIGSELK-KLAQRRIN 71
            ||.|.|....|.:.:...:||..:.:  .::....|:..:.||.|   |..|...| :..::.:.
Human    34 PEVPYSSGATSSTNNPEFVEDLSQGQLLQSESSNAAEGNEQRHEDEQRSKRGGWSKGRKRKKPLR 98

  Fly    72 VAGAPKMPLNGYVRFMNDRREELRREQPQRTALEHTRIIGEEWHQLPEERKLPYIEAAAKDKAIY 136
            .:.|||.||.|||||||:|||:||.::|:....|.||::|.||.:||.|.|..|::.|.:||..|
Human    99 DSNAPKSPLTGYVRFMNERREQLRAKRPEVPFPEITRMLGNEWSKLPPEEKQRYLDEADRDKERY 163

  Fly   137 QEQLQMFLKEHPEIVANELAKAKKATKLDGSPKEKTPKGESALGKAKKTKAKPVKRQSEDPDDVP 201
            .::|:.:.|             .:|.|:.....:...||:|....|.:......::::|
Human   164 MKELEQYQK-------------TEAYKVFSRKTQDRQKGKSHRQDAARQATHDHEKETE------ 209

  Fly   202 LAKVKRAQTPPPPTPPAAPVQPPPSSVPPATPAPRPLQPGEIPIYTNEFIEHNRSTENELRTLRK 266
               ||....                              .:|||:|.||:.|:::.|.|||.|||
Human   210 ---VKERSV------------------------------FDIPIFTEEFLNHSKAREAELRQLRK 241

  Fly   267 AKTDLEQQNAVLEQHVDNTKAGYAKVMGEVTELMEENQRLETYLRALRQKLVAALGGISMPPLEP 331
            :..:.|::||.|::||::.:....|:..:|.:....|..|:.:|..|||.|.::...:   ||..
Human   242 SNMEFEERNAALQKHVESMRTAVEKLEVDVIQERSRNTVLQQHLETLRQVLTSSFASM---PLPG 303

  Fly   332 SG--PSVGNIDKYIRHLAGLV---TQPSNVTLIKAREALRKVD 369
            ||  |:|..||.|:..|..::   .|.:...:...||.:.::|
Human   304 SGETPTVDTIDSYMNRLHSIILANPQDNENFIATVREVVNRLD 346

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hmg-2	NP_611553.1	HMG-box_HMG20	75..154	CDD:438796	35/78 (45%)
HMG20A	NP_060670.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..113		22/78 (28%)
		DUF5401	<59..313	CDD:375164	86/308 (28%)
		HMG-box_HMG20A	83..186	CDD:438833	39/115 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	179..211		5/40 (13%)