DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hmg-2 and HMG20A

DIOPT Version :9

Sequence 1:	NP_611553.1	Gene:	Hmg-2 / 37407	FlyBaseID:	FBgn0026582	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_001291433.1	Gene:	HMG20A / 10363	HGNCID:	5001	Length:	347	Species:	Homo sapiens

Alignment Length:	368	Identity:	101/368 - (27%)
Similarity:	171/368 - (46%)	Gaps:	66/368 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PESPVSLPIASQSMDTATIEDFDEDK--PAKGKKKAKNPKGRHSD---SDIGSELK-KLAQRRIN 71
            ||.|.|....|.:.:...:||..:.:  .::....|:..:.||.|   |..|...| :..::.:.
Human    34 PEVPYSSGATSSTNNPEFVEDLSQGQLLQSESSNAAEGNEQRHEDEQRSKRGGWSKGRKRKKPLR 98

  Fly    72 VAGAPKMPLNGYVRFMNDRREELRREQPQRTALEHTRIIGEEWHQLPEERKLPYIEAAAKDKAIY 136
            .:.|||.||.|||||||:|||:||.::|:....|.||::|.||.:||.|.|..|::.|.:||..|
Human    99 DSNAPKSPLTGYVRFMNERREQLRAKRPEVPFPEITRMLGNEWSKLPPEEKQRYLDEADRDKERY 163

  Fly   137 QEQLQMFLKEHPEIVANELAKAKKATKLDGSPKEKTPKGESALGKAKKTKAKPVKRQSEDPDDVP 201
            .::|:.:.|             .:|.|:.....:...||:|....|.:......::::|
Human   164 MKELEQYQK-------------TEAYKVFSRKTQDRQKGKSHRQDAARQATHDHEKETE------ 209

  Fly   202 LAKVKRAQTPPPPTPPAAPVQPPPSSVPPATPAPRPLQPGEIPIYTNEFIEHNRSTENELRTLRK 266
               ||....                              .:|||:|.||:.|:::.|.|||.|||
Human   210 ---VKERSV------------------------------FDIPIFTEEFLNHSKAREAELRQLRK 241

  Fly   267 AKTDLEQQNAVLEQHVDNTKAGYAKVMGEVTELMEENQRLETYLRALRQKLVAALGGISMPPLEP 331
            :..:.|::||.|::||::.:....|:..:|.:....|..|:.:|..|||.|.::...:   ||..
Human   242 SNMEFEERNAALQKHVESMRTAVEKLEVDVIQERSRNTVLQQHLETLRQVLTSSFASM---PLPG 303

  Fly   332 SG--PSVGNIDKYIRHLAGLV---TQPSNVTLIKAREALRKVD 369
            ||  |:|..||.|:..|..::   .|.:...:...||.:.::|
Human   304 SGETPTVDTIDSYMNRLHSIILANPQDNENFIATVREVVNRLD 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hmg-2	NP_611553.1	HMGB-UBF_HMG-box	76..141	CDD:238686	32/64 (50%)
HMG20A	NP_001291433.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..113		22/78 (28%)
		DUF5401	<59..313	CDD:375164	86/308 (28%)
		HMGB-UBF_HMG-box	103..168	CDD:238686	32/64 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	179..211		5/40 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	77	1.000	Domainoid score	I8882
eggNOG	1	0.900	-	-		E1_COG5648
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32399
Inparanoid	1	1.050	144	1.000	Inparanoid score	I4452
Isobase	1	0.950	-	0	Normalized mean entropy	S2285
OMA	1	1.010	-	-		QHG45555
OrthoDB	1	1.010	-	-		D1458939at2759
OrthoFinder	1	1.000	-	-		FOG0003510
OrthoInspector	1	1.000	-	-		otm41200
orthoMCL	1	0.900	-	-		OOG6_106551
Panther	1	1.100	-	-	O	PTHR46040
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3288
SonicParanoid	1	1.000	-	-		X2882
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820