DRSC/TRiP Functional Genomics Resources

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Protein Alignment Magi and Magi3

DIOPT Version :10

Sequence 1:NP_611551.1 Gene:Magi / 37403 FlyBaseID:FBgn0034590 Length:1202 Species:Drosophila melanogaster
Sequence 2:NP_001152826.1 Gene:Magi3 / 99470 MGIID:1923484 Length:1476 Species:Mus musculus


Alignment Length:1125 Identity:322/1125 - (28%)
Similarity:456/1125 - (40%) Gaps:387/1125 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   158 EKSGGLAPPG---GHHLRPPPPPA-----LKKSASAVI-----GNSASREDVASLSGTSSLNSQM 209
            |:||.|...|   |:....|.|||     .......|:     ...:.|:...|:|....::|.:
Mouse   174 EESGALLESGTYDGNFYGTPKPPAEPSPFQPDPVDQVLFDNEFDTESQRKRTTSVSKMERMDSSL 238

  Fly   210 SVHNQFISGLPSNGIGSNGVHGGAATGRGGPPNSILKGSKENLLQNTYYNGETGDSSLGSECGVG 274
            ....:.......||.||                          ::....:.||      |:|.:.
Mouse   239 PEEEEDEDKEAVNGSGS--------------------------METREMHSET------SDCWMK 271

  Fly   275 DV--QHQNHESHDDPG-----DGLGPLPPKWETAYTERGELYFIDHNTGTSHWLDPRLSKYQKKS 332
            .|  .:|.:.|.|...     :.|.|||..||.|||:.|.:|||||||.|:.||||||.| :.|:
Mouse   272 TVPSYNQTNSSMDFRNYMMRDENLEPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCK-KAKA 335

  Fly   333 LEDCCEDELPYGWEKIEDSMYGMYFIDHVNRRTQYENPVLEAKRRAAEQSQQQQQMQQQQQQMQE 397
            .|||.:.|||||||||||..||.|::||:|::||:||||.||||:            :|..|.:.
Mouse   336 PEDCEDGELPYGWEKIEDPQYGTYYVDHLNQKTQFENPVEEAKRK------------KQLGQAEI 388

  Fly   398 QRSKTPTALSETMPTEAAEAHEQEEDESPMKLPYKFTRNPAELQGQRINTTLLKSSRGLGFTIVG 462
            ..:|          |:...||              |||:|::|:|..:..:|.||:.|.||||:|
Mouse   389 HSAK----------TDVERAH--------------FTRDPSQLKGVLVRASLKKSTMGFGFTIIG 429

  Fly   463 SDGSAGGDVEEFLQIKTVVPNGPAWLDGQLQTGDVLVYVNDTCVLGYTHHDMVNIFQSILPGERA 527
            .|..     :||||:|.|:.:|||..||::..|||:|.:|..||||:||.|:|.:||.:...:..
Mouse   430 GDRP-----DEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYV 489

  Fly   528 ALEVCRGYPLPFDPNDPNTEVV-TTMAVDGR----------------------ESDKQRRLNMDG 569
            .|.:|||||||.|..||..::| .|..::|:                      ::.|..::....
Mouse   490 NLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNTQDFKLGAMVLDQNGKSGQILASD 554

  Fly   570 NYNFLDLSGEGAKKTSGSGSGFILMKKPEIYTFSIMKGSMGFGFTIADSACGQIVKKILDRNCCT 634
            ..|....|.|.....:.|||     .:||:.|..::||..||||.||||..||.||.|||...|.
Mouse   555 RLNGPSESSEQRASLASSGS-----SQPELVTIPLIKGPKGFGFAIADSPTGQKVKMILDSQWCQ 614

  Fly   635 QLMEGDVLLEINGLNVRNKPHFYVVELLKECSQTTPTAVKIQRTPPDPPANNTLAQLNQVGNVAK 699
            .|.:||::.||...||:|..|..|||:||:                                   
Mouse   615 GLQKGDIIKEIYHQNVQNLTHLQVVEVLKQ----------------------------------- 644

  Fly   700 LRKNFVGSGLFRSKTPTADLYSTQVKEVLPMRPKTPLVDTRRSRVQIQSPNNEVDDEGDGAAAAE 764
                                        .|:....||:..|                  |...:.
Mouse   645 ----------------------------FPVGADVPLLILR------------------GGPCSP 663

  Fly   765 RKPLQLQTQGKSNS-SLQELDDIPYMDPYPKISRLSERLAEVTLQGDANGGIYGMPPSMQPLPLP 828
            .|..:.:|..|.|| ||:.::     :|.|                             ||:|.|
Mouse   664 TKTAKTKTDTKENSGSLETIN-----EPIP-----------------------------QPMPFP 694

  Fly   829 LAHHESCYCYDCQAQRYRPGYFVQAQQAAMSGTTGQYSPLQTAHLQNERIQRRVNELLSDRRRVG 893
                                     .....||     ||    .|....:..:...|..|:    
Mouse   695 -------------------------PSIIRSG-----SP----KLDPSEVYLKSKTLYEDK---- 721

  Fly   894 FANLDPPQQMQHSPSWRNGALLDVSEDADQCELTEVTLERQALGFGFRIVGGTEEGSQVTVGHIV 958
                 ||.                ::|.|      |.|.:|..|||||::||......:.:|.|:
Mouse   722 -----PPN----------------TKDLD------VFLRKQESGFGFRVLGGDGPDQSIYIGAII 759

  Fly   959 PGGAADQDQRINTGDEILSIDGINVLNSSHHKVVSLVGESALRGQVTMILRRR------------ 1011
            |.|||::|.|:...||::.||||.|...||.:|:.|:..:|..|.|.:.:||:            
Mouse   760 PLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDES 824

  Fly  1012 -------RTPLLQQAPVSTQLRRYP---YDVIVSRHENEGFGFVIISSSN--------HYYGSTI 1058
                   .:|.|.:|.:.|  |..|   |||.:.|.|||||||||::|.:        |    .|
Mouse   825 HQAFSQNGSPRLNRAELPT--RSAPQEAYDVTLQRKENEGFGFVILTSKSKPPPGVIPH----KI 883

  Fly  1059 GKLIPGSPADRCGELKVGDRIVAVNRIEIAGMSHGDVVNLIKESGLHVRLTIGVPLKEGGPSPGG 1123
            |::|.||||||||.|||||.|.|||...|..:||.::|.|||::|:.|.||:....:..||..|.
Mouse   884 GRVIDGSPADRCGGLKVGDHISAVNGQSIVDLSHDNIVQLIKDAGVTVTLTVVAEEEHHGPPSGT 948

  Fly  1124 SSVGVSSNTPLQASPSLLKAQLSHQQQLPQQH--LQQAQLNH----------------------- 1163
            :|.        :.||:|             ||  :.|||.||                       
Mouse   949 NSA--------RQSPAL-------------QHRPMGQAQANHIPGDRIALEGEIGRDVCSSYRHS 992

  Fly  1164 --HHQHLEMPMSMPVPGHGS 1181
              .|:||..|.:..:...||
Mouse   993 WSDHKHLAQPDTAVISVVGS 1012

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MagiNP_611551.1 WW 294..323 CDD:459800 18/28 (64%)
WW 342..372 CDD:238122 20/29 (69%)
PDZ1_MAGI-1_3-like 444..533 CDD:467213 37/88 (42%)
PDZ2_MAGI-1_3-like 597..677 CDD:467214 35/79 (44%)
PDZ3_MAGI-1_3-like 926..1010 CDD:467215 32/83 (39%)
PDZ4_MAGI-1_3-like 1029..1111 CDD:467216 47/92 (51%)
Magi3NP_001152826.1 PDZ0_MAGI-1_3-like 14..106 CDD:467212
Interaction with ADRB1 and TGFA. /evidence=ECO:0000269|PubMed:15652357 18..108
NK 125..>199 CDD:450170 10/24 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 184..266 16/113 (14%)
HUL4 <211..>373 CDD:227354 65/194 (34%)
WW 297..329 CDD:197736 21/31 (68%)
WW 345..375 CDD:238122 20/29 (69%)
PDZ1_MAGI-1_3-like 411..495 CDD:467213 37/88 (42%)
Interaction with PTEN. /evidence=ECO:0000250 413..495 37/86 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 551..575 6/28 (21%)
PDZ2_MAGI-1_3-like 577..658 CDD:467214 39/161 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 664..691 10/60 (17%)
PDZ3_MAGI-1_3-like 727..811 CDD:467215 34/89 (38%)
Interaction with ADGRB1. /evidence=ECO:0000250 729..811 33/87 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 818..844 4/27 (15%)
PDZ4_MAGI-1_3-like 851..936 CDD:467216 46/88 (52%)
Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000250 852..939 45/90 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 939..966 10/47 (21%)
PDZ5_MAGI-1_3-like 1020..1102 CDD:467217
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1109..1151
PTZ00112 1115..>1404 CDD:240274
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1168..1476
Blue background indicates that the domain is not in the aligned region.

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