DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Magi and AREL1

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	NP_001034568.1	Gene:	AREL1 / 9870	HGNCID:	20363	Length:	823	Species:	Homo sapiens

Alignment Length:	775	Identity:	142/775 - (18%)
Similarity:	236/775 - (30%)	Gaps:	306/775 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   265 SSLGSECGVGDVQHQNH-------ESHDDPGDG----------------LGPLPPK-----WETA 301
            |:|...||      |.|       :.:|:|.:.                |||...:     :|.:
Human   175 STLVLTCG------QPHTLQIVPRDEYDNPTNNSMSLRDEHNYTLSIHELGPQEEESTGVSFEKS 233

  Fly   302 YTERGELYFID-----HNTGTSHWLDPRLSKYQKKSLED-------CCEDELPYGWEKIEDSMYG 354
            .|...:.:.:.     |:.|..|    ....||.:.:.:       ..|||.......:..|...
Human   234 VTSNRQTFQVFLRLTLHSRGCFH----ACISYQNQPINNGEFDIIVLSEDEKNIVERNVSTSGVS 294

  Fly   355 MYFIDHVNRRTQYENPVLEAKRRAAEQSQQQQQMQQQQQQMQEQRSKTPTALSETMPTEAAEAHE 419
            :||..::...|...:                .........|...:.:..||:.|......:|.|.
Human   295 IYFEAYLYNATNCSS----------------TPWHLPPMHMTSSQRRPSTAVDEEDEDSPSECHT 343

  Fly   420 QEEDESPMKL-----PYKFTRNPAELQ--GQRINTTLLKSSRGLGFTIVGSDGSAGGDVEEFLQI 477
            .|:.:.|.|:     |.:|:.....|:  ..|:.|  .:...|..|:.:|.|     .|.:.|.:
Human   344 PEKVKKPKKVYCYVSPKQFSVKEFYLKIIPWRLYT--FRVCPGTKFSYLGPD-----PVHKLLTL 401

  Fly   478 KTVVPNG---PAWL---DGQLQTGDVLVYVNDTCVLGYTHHDMVNIFQSIL-------PGERAAL 529
              ||.:|   |..|   :..:.....:..::.......|..|.||.||..|       |..:..|
Human   402 --VVDDGIQPPVELSCKERNILAATFIRSLHKNIGGSETFQDKVNFFQRELRQVHMKRPHSKVTL 464

  Fly   530 EVCRGYPLP--------FDPND--PNTEVV--------------------------TTMAVDGRE 558
            :|.|...|.        |..:|  .|.|||                          ||..:..|.
Human   465 KVSRHALLESSLKATRNFSISDWSKNFEVVFQDEEALDWGGPRREWFELICKALFDTTNQLFTRF 529

  Fly   559 SDKQR-------------RLNMDGNYNFLDLSGEGAKKTSGSGSGFILMKKPEIYTFSIMKGSMG 610
            ||..:             ||.|   |.|               :|.::.|       .:.:.|:|
Human   530 SDNNQALVHPNPNRPAHLRLKM---YEF---------------AGRLVGK-------CLYESSLG 569

  Fly   611 FGFTIADSACGQIVKKILDRNCCTQLMEGDVLLEINGLNVRNK------PHFY---VVELLKECS 666
                   .|..|:|:....|:         .|.:|.||.:..|      |.||   |..:|
Human   570 -------GAYKQLVRARFTRS---------FLAQIIGLRMHYKYFETDDPEFYKSKVCFIL---- 614

  Fly   667 QTTPTAVKIQRTPPDPPANNTLAQL---------NQVGNVAKLRKNFVGSGLFRSKTPTADL--- 719
                              ||.::::         |:.|.:.|:.:...|.    ::||..:.
Human   615 ------------------NNDMSEMELVFAEEKYNKSGQLDKVVELMTGG----AQTPVTNANKI 657

  Fly   720 ----------YSTQVKEVLP--MRPKTPLVDTRRSRVQIQSPNN--EVDDEGDGAAAAERKPLQL 770
                      .::||||.:.  ::....||           |.|  .:.||.:         |:|
Human   658 FYLNLLAQYRLASQVKEEVEHFLKGLNELV-----------PENLLAIFDENE---------LEL 702

  Fly   771 QTQGKSNSSLQELDDIPYMDP-------------YPKISRLSE----RLAEVTLQGDAN---GGI 815
            ...|..:.|:.:......:..             :..:|.|::    ||.:.| .|.:.   ||.
Human   703 LMCGTGDISVSDFKAHAVVVGGSWHFREKVMRWFWTVVSSLTQEELARLLQFT-TGSSQLPPGGF 766

  Fly   816 YGMPPSMQPL------PLPLAHHESCY---C---YDCQAQRYRPGYFVQAQQAAMSGTTG 863
            ..:.||.|.:      .||.||  :|:   |   ||...:.:|     ..|.|...|..|
Human   767 AALCPSFQIIAAPTHSTLPTAH--TCFNQLCLPTYDSYEEVHR-----MLQLAISEGCEG 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	5/38 (13%)
		WW	342..372	CDD:238122	4/29 (14%)
		PDZ	443..534	CDD:214570	23/103 (22%)
		DegQ	<455..534	CDD:223343	21/91 (23%)
		PDZ_signaling	606..668	CDD:238492	16/70 (23%)
		PDZ	925..1011	CDD:214570
		PDZ_signaling	1029..1110	CDD:238492
AREL1	NP_001034568.1	Filamin	52..158
		Filamin	56..154	CDD:395505
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	315..345		6/29 (21%)
		Interaction with SOCS2. /evidence=ECO:0000269\|PubMed:31578312	483..789		70/395 (18%)
		HECTc	486..820	CDD:214523	79/429 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900