DRSC/TRiP Functional Genomics Resources

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Protein Alignment Magi and MAGI2

DIOPT Version :9

Sequence 1:NP_001286661.1 Gene:Magi / 37403 FlyBaseID:FBgn0034590 Length:1202 Species:Drosophila melanogaster
Sequence 2:XP_016868329.1 Gene:MAGI2 / 9863 HGNCID:18957 Length:1540 Species:Homo sapiens


Alignment Length:1237 Identity:365/1237 - (29%)
Similarity:517/1237 - (41%) Gaps:401/1237 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   148 HGNGTVTG------------NGEKSGGLAPPGGHH------LRPP--PPPALKKSASAVI----- 187
            |..|.|.|            ..||||.|...|.:.      .:||  |.|.|......::     
Human   145 HKEGEVPGVDYIFITVEDFMELEKSGALLESGTYEDNYYGTPKPPAEPAPLLLNVTDQILPGATP 209

  Fly   188 --------GNSASREDVASLSGTSSLNSQMSVHNQFISGLPSNGI---GSNGVHGGAATGRGG-- 239
                    ..|.|..:.||:........:..|.|       .||:   ..:..|...:.|..|  
Human   210 SAEGKRKRNKSVSNMEKASIEPPEEEEEERPVVN-------GNGVVVTPESSEHEDKSAGASGEM 267

  Fly   240 ---PPNSILKGSKENLLQNTYYNGETGDSSLGSECGVGDVQHQNHESHDDPGDGLGPLPPKWETA 301
               |..:.:....|.|.:.                 :.|.:....|.:::|    .|||..||.|
Human   268 PSQPYPAPVYSQPEELKEQ-----------------MDDTKPTKPEDNEEP----DPLPDNWEMA 311

  Fly   302 YTERGELYFIDHNTGTSHWLDPRLSKYQKKSLEDCCEDELPYGWEKIEDSMYGMYFIDHVNRRTQ 366
            |||:||:|||||||.|:.||||||:| :.|..|:|.|:|||||||||:|.:||.|::||:|||||
Human   312 YTEKGEVYFIDHNTKTTSWLDPRLAK-KAKPPEECKENELPYGWEKIDDPIYGTYYVDHINRRTQ 375

  Fly   367 YENPVLEAKRRAAEQSQQQQQMQQQQQQMQ----EQRSKTPTALSETMPTEAAEAHEQEEDES-- 425
            :|||||||||:..:.:....::..:..|..    :..|.|........|..|.|......|.|  
Human   376 FENPVLEAKRKLQQHNMPHTELGTKPLQAPGFRVDSSSWTLPRPKSIRPRAAPERSRSVNDLSYY 440

  Fly   426 ---PMKLPY-----KFTRNPAELQGQRINTTLLKSSRGLGFTIVGSDGSAGGDVEEFLQIKTVVP 482
               |...|:     .|||:.::|:|..::|||.||:.|.||||:|.|     :.:||||:|:|:|
Human   441 QRDPAGRPWLFEKPLFTRDASQLKGTFLSTTLKKSNMGFGFTIIGGD-----EPDEFLQVKSVIP 500

  Fly   483 NGPAWLDGQLQTGDVLVYVNDTCVLGYTHHDMVNIFQSILPGERAALEVCRGYPLPFDPNDPNTE 547
            :|||..||:::||||:||:|:.||||:||.|:|.:|||:..|:...|.:||||||||||.||...
Human   501 DGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANS 565

  Fly   548 VVTTMA---------VDGRE-------------------------------SDKQRRLNMDGNY- 571
            :|..:|         |:||.                               :|.|    :||.| 
Human   566 MVPPLAIMERPPPVMVNGRHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQ----LDGTYP 626

  Fly   572 -----NFLDLSGEGAKKTSGSGSGFILMKKPEIYTFSIMKGSMGFGFTIADSACGQIVKKILDRN 631
                 :.:.::..||.:.             |:.|.:|:||:.|||||||||..||.||:|||..
Human   627 PPVHDDNVSMASSGATQA-------------ELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQ 678

  Fly   632 CCTQLMEGDVLLEINGLNVRNKPHFYVVELLKECSQTTPTAVKIQRTPPDPPANNTLAQLNQVGN 696
            .|..|.|||:::|||..||:|..|..||::||:|...:.|::.|.|                   
Human   679 GCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPIGSETSLIIHR------------------- 724

  Fly   697 VAKLRKNFVGSGLFRSKTPTADLYSTQVKEVLPMRPKTPLVDTRRSRVQIQSPNNEVDDEGDGAA 761
                      .|.|.                 |.:...|::|                       
Human   725 ----------GGFFS-----------------PWKTPKPIMD----------------------- 739

  Fly   762 AAERKPLQLQTQGKSNSSLQELDDIPYMDPYPKISRLSERLAEVTLQGDANGGIYGMPPSMQPLP 826
                   :.:.||...:||                                    ..|...|.||
Human   740 -------RWENQGSPQTSL------------------------------------SAPAIPQNLP 761

  Fly   827 LPLAHHESCYCYDCQAQRYRPGYFVQAQQAAMSGTTGQYSPLQTAHLQNERIQRRVNELLSDRRR 891
            .|.|.|.|.:                      ..:|..:.|.:....:.....|.:.|   .|::
Human   762 FPPALHRSSF----------------------PDSTEAFDPRKPDPYELYEKSRAIYE---SRQQ 801

  Fly   892 VGFANLDPPQQMQHSPSWRNGALLDVSEDADQCELTEVTLERQALGFGFRIVGGTEEGSQVTVGH 956
            |      ||         |....:| |...|..|| :|.|.|...||||||:||.|.|..:.:|.
Human   802 V------PP---------RTSFRMD-SSGPDYKEL-DVHLRRMESGFGFRILGGDEPGQPILIGA 849

  Fly   957 IVPGGAADQDQRINTGDEILSIDGINVLNSSHHKVVSLVGESALRGQVTMILRRR---------- 1011
            ::..|:||:|.|::.|||::.:|||.|...:|..|:.|:..:|..|||.:.:||:          
Human   850 VIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPE 914

  Fly  1012 --RTPLLQQAPVST--QLRRYPY-----------------------------DVIVSRHENEGFG 1043
              |:|    ..|||  ...|..|                             ||::.|.||||||
Human   915 NGRSP----GSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKENEGFG 975

  Fly  1044 FVIISSSNH-YYGST------IGKLIPGSPADRCGELKVGDRIVAVNRIEIAGMSHGDVVNLIKE 1101
            ||||||.|. ..|||      ||::|.|||||||.:|||||||:|||...|..|.|.|:|.|||:
Human   976 FVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKD 1040

  Fly  1102 SGLHVRLTIGVPLKE-----GGP-----SPGGSSVGVSSNTPL-QASPSLLKAQLSHQQQLPQQH 1155
            :||.|.|.| :|.:|     ..|     ||......::..:|| |.||:...:.::  |..|.|.
Human  1041 AGLSVTLRI-IPQEELNSPTSAPSSEKQSPMAQQSPLAQQSPLAQPSPATPNSPIA--QPAPPQP 1102

  Fly  1156 LQ-QAQLNHHHQHL-------------------EMPMSMPVPGHGSYLERPSNNISATLALHQQP 1200
            || |...|.:...:                   :.|:....|..|.|.:.|..:       ::||
Human  1103 LQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPPLDYRQPPGGDYQQPPPLD-------YRQP 1160

  Fly  1201 QL 1202
            .|
Human  1161 PL 1162

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MagiNP_001286661.1 WW 294..323 CDD:278809 20/28 (71%)
WW 342..372 CDD:238122 21/29 (72%)
PDZ 443..534 CDD:214570 45/90 (50%)
DegQ <455..534 CDD:223343 40/78 (51%)
PDZ_signaling 606..668 CDD:238492 35/61 (57%)
PDZ 925..1011 CDD:214570 36/85 (42%)
PDZ_signaling 1029..1110 CDD:238492 52/116 (45%)
MAGI2XP_016868329.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 107 1.000 Domainoid score I6554
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 517 1.000 Inparanoid score I1288
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D148234at33208
OrthoFinder 1 1.000 - - FOG0000831
OrthoInspector 1 1.000 - - otm40810
orthoMCL 1 0.900 - - OOG6_102187
Panther 1 1.100 - - LDO PTHR10316
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X573
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.830

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