DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Magi and BAG3

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	NP_004272.2	Gene:	BAG3 / 9531	HGNCID:	939	Length:	575	Species:	Homo sapiens

Alignment Length:	158	Identity:	39/158 - (24%)
Similarity:	58/158 - (36%)	Gaps:	28/158 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   293 PLPPKWETAY-TERGELYFIDHNTGTSHWLDPRLSKYQKKSLEDCCE------DELPYGWE--KI 348
            ||||.||... .:.|..:|:|||:.|:.|.|||:.....|.......      ..||...|  .:
Human    21 PLPPGWEIKIDPQTGWPFFVDHNSRTTTWNDPRVPSEGPKETPSSANGPSREGSRLPPAREGHPV 85

  Fly   349 EDSMYGMYFIDHV------NRRTQ----YENPVL-----EAKRRAAEQSQQQQQMQQQQQQMQEQ 398
            ...:...|....|      ||:..    |..|.:     ||...|.::||...:...:..|..:|
Human    86 YPQLRPGYIPIPVLHEGAENRQVHPFHVYPQPGMQRFRTEAAAAAPQRSQSPLRGMPETTQPDKQ 150

  Fly   399 RSKTPTALSETMPTEAAEAHEQEEDESP 426
            ..:...|.:...|.    :|..|..:||
Human   151 CGQVAAAAAAQPPA----SHGPERSQSP 174

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	12/29 (41%)
		WW	342..372	CDD:238122	8/41 (20%)
		PDZ	443..534	CDD:214570
		DegQ	<455..534	CDD:223343
		PDZ_signaling	606..668	CDD:238492
		PDZ	925..1011	CDD:214570
		PDZ_signaling	1029..1110	CDD:238492
BAG3	NP_004272.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..92		20/70 (29%)
		WW	21..53	CDD:197736	14/31 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	123..200		13/56 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..421
		BAG	421..498	CDD:214591
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..575
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900