DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Magi and TRIP12

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	XP_024308991.1	Gene:	TRIP12 / 9320	HGNCID:	12306	Length:	2092	Species:	Homo sapiens

Alignment Length:	1491	Identity:	263/1491 - (17%)
Similarity:	430/1491 - (28%)	Gaps:	566/1491 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 ARGVATAKSPTDY------------LMLQQQQQQQQQQQQHFNS--NHFYQQQQPQQLAPLNASH 70
            :|||..:.|| ||            ..||..:...:..:.|..|  .|..|:||.:.....:.|.
Human   111 SRGVKRSASP-DYNRTNSPSSAKKPKALQHTESPSETNKPHSKSKKRHLDQEQQLKSAQSPSTSK 174

  Fly    71 QHQHSHPHPHPHPVAAATSFATFNGNSNLNSSLANGSSRKFNCSRDNVDDGGDAGEMAAASQTLS 135
            .|...         :.||..:.........||.....|...:...:  :......::|:.|.|.:
Human   175 AHTRK---------SGATGGSRSQKRKRTESSCVKSGSGSESTGAE--ERSAKPTKLASKSATSA 228

  Fly   136 SAGTDVVGNGSGHGNGTVTGNGEKSGGLAPPGGHHL---RPPPPPALKKSASAVIGNSASREDVA 197
            .||...:.:.|...:.:.:.:...|.....|.|..:   :........:|||:.....:|||...
Human   229 KAGCSTITDSSSAASTSSSSSAVASASSTVPPGARVKQGKDQNKARRSRSASSPSPRRSSREKEQ 293

  Fly   198 SLSGTSSLNSQMSVHNQFISGLPSNGIGSNGVHGGAATGRGGPPNSILKGSKENLLQNTYYNGET 262
            |.:|.||.....:..:..:| ||...:...| ...:.|.:.||  |.|:....:|.::|....|:
Human   294 SKTGGSSKFDWAARFSPKVS-LPKTKLSLPG-SSKSETSKPGP--SGLQAKLASLRKSTKKRSES 354

  Fly   263 GDSSLGSECGVGDVQHQNHESHDDPGDGLGPLPPKWETAYTERGELYFIDHNTGTSHWLDPRLSK 327
                                            ||         .||              |.|.:
Human   355 --------------------------------PP---------AEL--------------PSLRR 364

  Fly   328 YQKKSLEDCCEDELPYGWEKIEDSMYGMYFIDHVNRRTQYENPVLEAKRRAAEQSQQQQQMQQQQ 392
            ..::.....|......|        .|:                  .||.|||..:|::....:.
Human   365 STRQKTTGSCASTSRRG--------SGL------------------GKRGAAEARRQEKMADPES 403

  Fly   393 QQMQEQRSKTPTALSETMPTEAAEAHEQEEDESPMKLPYKFTRNPAELQGQRINTTLLKSSRGLG 457
            .|                  ||..:.....||:|              ||...::::   :..:|
Human   404 NQ------------------EAVNSSAARTDEAP--------------QGAAASSSV---AGAVG 433

  Fly   458 FTIVG---SDGSAGGDVEEFLQIKTVVPN-----GPAW-------------------LDGQLQTG 495
            .|..|   ||.|..|.::..|:.:.:.|:     ||..                   |.| ||..
Human   434 MTTSGESESDDSEMGRLQALLEARGLPPHLFGPLGPRMSQLFHRTIGSGASSKAQQLLQG-LQAS 497

  Fly   496 D-------------VLVYVNDTCVLGYTHHDMVNIFQSILPGERAALEV----------CRGYPL 537
            |             :||..|:..:.|:.       .:|::|.....|::          ||....
Human   498 DESQQLQAVIEMCQLLVMGNEETLGGFP-------VKSVVPALITLLQMEHNFDIMNHACRALTY 555

  Fly   538 PFDPNDPNTEVV------------TTMAVDGRESDKQRRLNMDGNYNFLDLSGEGAKKTSGSGSG 590
            ..:....::.||            ....:|..| .....|.|        ||...:|....:|..
Human   556 MMEALPRSSAVVVDAIPVFLEKLQVIQCIDVAE-QALTALEM--------LSRRHSKAILQAGGL 611

  Fly   591 FILMKKPEIYTFSIMKGSMGFGFTIADSACGQIV----------------------KKILDRNC- 632
            ...:...|.::.:..:.::    .||.:.|..|.                      ||.::..|
Human   612 ADCLLYLEFFSINAQRNAL----AIAANCCQSITPDEFHFVADSLPLLTQRLTHQDKKSVESTCL 672

  Fly   633 C---------------TQLMEGDVLLEINGLNVRNKP------HFYVVELLK-ECSQTTPTAVKI 675
            |               .|:...|:|..:..|.|...|      ...||.:.. .||.....||::
Human   673 CFARLVDNFQHEENLLQQVASKDLLTNVQQLLVVTPPILSSGMFIMVVRMFSLMCSNCPTLAVQL 737

  Fly   676 QRTPPDPPANNTLAQLNQVGNVAKLRKNFVGSGLFRS----------KTPTADLY--STQVKEVL 728
            .:.                 |:|: ..:|:..|....          ::| .:||  ::.:.|::
Human   738 MKQ-----------------NIAE-TLHFLLCGASNGSCQEQIDLVPRSP-QELYELTSLICELM 783

  Fly   729 PMRPKTPL--VDTRRSRVQIQS----------------PNNEVD--------------------- 754
            |..||..:  |||...:...|:                |.|.:|
Human   784 PCLPKEGIFAVDTMLKKGNAQNTDGAIWQWRDDRGLWHPYNRIDSRIIEVAAHQVGEDEISLSTL 848

  Fly   755 --------------DEGDGAA-AAERKPLQLQTQGKSNSSLQELDD--IPYMDPYPKISRLSERL 802
                          :|..|.| |.:|||..|.....|..|..:.||  ...|...|::::...:
Human   849 GRVYTIDFNSMQQINEDTGTARAIQRKPNPLANSNTSGYSESKKDDARAQLMKEDPELAKSFIK- 912

  Fly   803 AEVTLQG------DANGGIYGMPPSMQPLPLPLAHHESCYCYDCQAQRYRPGYFVQAQQAAMSGT 861
               ||.|      .::.|             |...|:      |.....|..||..|:
Human   913 ---TLFGVLYEVYSSSAG-------------PAVRHK------CLRAILRIIYFADAE------- 948

  Fly   862 TGQYSPLQTAHLQNERIQRRVNELLS--DRRRVGFANLDPPQQMQHSPS------WRNGALLDVS 918
                  |....|:|..:...:..:||  |.:.|..|.......||..|.      .|.|.:..|.
Human   949 ------LLKDVLKNHAVSSHIASMLSSQDLKIVVGALQMAEILMQKLPDIFSVYFRREGVMHQVK 1007

  Fly   919 EDADQCELTEVTLERQALGFGFRIVGGT---EEGSQVTVGHIVPGGAADQDQRINTGDEILSIDG 980
            ..|:...|  :|...:|...|...:|.|   ..|:.....|    .|||      .|...|
Human  1008 HLAESESL--LTSPPKACTNGSGSMGSTTSVSSGTATAATH----AAAD------LGSPSL---- 1056

  Fly   981 INVLNSSHHKVVSLVGESALRGQVTMILRRRR-------------------------TPLLQQAP 1020
                  .|.:..||  :.:.:|:::.:|:|:|                         :|...|:|
Human  1057 ------QHSRDDSL--DLSPQGRLSDVLKRKRLPKRGPRRPKYSPPRDDDKVDNQAKSPTTTQSP 1113

  Fly  1021 ---------------VSTQ-----------------LRRYPYDVIVSRHEN-EGFGFVIISSSNH 1052
                           :|||                 .|....|.|.:..|. :|:    |....|
Human  1114 KSSFLASLNPKTWGRLSTQSNSNNIEPARTAGGSGLARAASKDTISNNREKIKGW----IKEQAH 1174

  Fly  1053 -----YYGSTIGKLIPGS-PADRCGELKVGDRIVAVNR-------------IEIAG-MSHGDVVN 1097
                 |:.|   :.:.|| ||     |.|..|:.|...             :||.. :|..||.:
Human  1175 KFVERYFSS---ENMDGSNPA-----LNVLQRLCAATEQLNLQVDGGAECLVEIRSIVSESDVSS 1231

  Fly  1098 L-IKESGLHVRLTIGVPLKE-------------------GGPSPGGSSVG---VSSNTPLQASPS 1139
            . |:.||...:|.:.:..|.                   ..|.||...:|   ...|.||.|...
Human  1232 FEIQHSGFVKQLLLYLTSKSEKDAVSREIRLKRFLHVFFSSPLPGEEPIGRVEPVGNAPLLALVH 1296

  Fly  1140 LLKAQLSHQQQLPQQHLQQAQLNHHHQHLEMPMSMPVPGHGSYLERPSNNISATLALHQQP 1200
            .:...||..:|.|        :..|    :.|......|.||...:..|.......|.:.|
Human  1297 KMNNCLSQMEQFP--------VKVH----DFPSGNGTGGRGSQALKFFNTHQLKCQLQRHP 1345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	4/28 (14%)
		WW	342..372	CDD:238122	2/29 (7%)
		PDZ	443..534	CDD:214570	24/140 (17%)
		DegQ	<455..534	CDD:223343	24/128 (19%)
		PDZ_signaling	606..668	CDD:238492	18/106 (17%)
		PDZ	925..1011	CDD:214570	18/88 (20%)
		PDZ_signaling	1029..1110	CDD:238492	25/102 (25%)
TRIP12	XP_024308991.1	SR-25	99..>233	CDD:313680	27/133 (20%)
		Arm_3	489..>714	CDD:330530	39/245 (16%)
		WWE	808..874	CDD:308464	7/65 (11%)
		HECTc	1690..2090	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900