DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Magi and MAGI1

DIOPT Version :9

Sequence 1:	NP_001286661.1	Gene:	Magi / 37403	FlyBaseID:	FBgn0034590	Length:	1202	Species:	Drosophila melanogaster
Sequence 2:	NP_001028229.1	Gene:	MAGI1 / 9223	HGNCID:	946	Length:	1462	Species:	Homo sapiens

Alignment Length:	1173	Identity:	376/1173 - (32%)
Similarity:	502/1173 - (42%)	Gaps:	404/1173 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 EKSGGLAPPG---GHHLRPPPPPALKKSASAVIGNSASREDVASLSGTSSLNSQMSVHNQFISGL 219
            |:||.|...|   |::...|.||:...|...:.              |.:|:|..|
Human   171 EQSGTLLEVGTYEGNYYGTPKPPSQPVSGKVIT--------------TDALHSLQS--------- 212

  Fly   220 PSNGIGSNGVHGGAATGRGGPPNSILKGSKE-NLLQNT----YYNGETGD-----SSLGSECGVG 274
                               |...|..|.:|. |.:||.    ..|.|..|     ||..::.|
Human   213 -------------------GSKQSTPKRTKSYNDMQNAGIVHAENEEEDDVPEMNSSFTADSG-- 256

  Fly   275 DVQHQNHESHD----------------DPG------------DGLGPLPPKWETAYTERGELYFI 311
              :.:.|...:                ||.            |.|||||..||.||||.||:|||
Human   257 --EQEEHTLQETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFI 319

  Fly   312 DHNTGTSHWLDPRLSKYQKKSLEDCCED------------ELPYGWEKIEDSMYGMYFIDHVNRR 364
            ||||.|:.|||||....|:|.||:|.:|            |||.|||||||.:||:|::||:||:
Human   320 DHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELDSELELPAGWEKIEDPVYGIYYVDHINRK 384

  Fly   365 TQYENPVLEAKRRAAEQSQQQQQMQQQQQQMQEQRSKT-----------PTALSETMPTEAAEAH 418
            ||||||||||||:...:.|||||.||||||.|:|:.:|           |..:....|:....|.
Human   385 TQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAR 449

  Fly   419 EQEEDESPMKLPYKFTRNPAELQGQRINTTLLKSSRGLGFTIVGSDGSAGGDVEEFLQIKTVVPN 483
            |......|.     |||||:||:|:.|:|.|.|||||.|||:||.|     :.:||||||::|.:
Human   450 EVPLQGKPF-----FTRNPSELKGKFIHTKLRKSSRGFGFTVVGGD-----EPDEFLQIKSLVLD 504

  Fly   484 GPAWLDGQLQTGDVLVYVNDTCVLGYTHHDMVNIFQSILPGERAALEVCRGYPLPFDPNDPNTEV 548
            |||.|||:::||||:|.||||||||:||..:|.|||||..|....||:||||||||||:||||.:
Human   505 GPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSL 569

  Fly   549 VTTMA--------VDGRE--------SDKQRRLN--MDGNYNFLDLSGEGAKKTSGSGSGF---- 591
            ||::|        |:|:|        |.|..::|  .|..      ....|...|.|..|:
Human   570 VTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGMKDAR------PSSPADVASNSSHGYPNDT 628

  Fly   592 -----ILMKKPEIYTFSIMKGSMGFGFTIADS--ACGQIVKKILDRNCCTQLMEGDVLLEINGLN 649
                 .:..:||:.|..|:||.||||||||||  ..||.||:|:|...|..|.|||:::|:|..|
Human   629 VSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKN 693

  Fly   650 VRNKPHFYVVELLKECSQTTPTAVKIQRTPPDPPANNTLAQLNQVGNVAKLRKNFVGSGLFRSKT 714
            |:...|..||::|.||.:.:...:.:||                             .|
Human   694 VQALTHNQVVDMLVECPKGSEVTLLVQR-----------------------------GG------ 723

  Fly   715 PTADLYSTQVKEVLPMRPKTPLVDTRRSRVQIQSPNNEVDDEGDGAAAAERKPLQLQTQGKSNSS 779
                         ||:..|:|                              |...|:.:...|||
Human   724 -------------LPVPKKSP------------------------------KSQPLERKDSQNSS 745

  Fly   780 LQELDDIPYMDPYPKISRLSERLAEVTLQGDANGGIYGMPPSMQPLPLPLAHHESCYCYDCQAQR 844
            ...:                          .::..::...||.....||               .
Human   746 QHSV--------------------------SSHRSLHTASPSHSTQVLP---------------E 769

  Fly   845 YRPGYFVQAQQAAMSGTTGQYSPLQTAHLQNERIQRRVNELLSDRRRVGFANLDPPQQMQHSPSW 909
            :.|   .:||....:.::||..|                              ||.:....|.|.
Human   770 FPP---AEAQAPDQTDSSGQKKP------------------------------DPFKIWAQSRSM 801

  Fly   910 RNGALLDVSEDADQCELTEVTLERQALGFGFRIVGGTEEGSQVTVGHIVPGGAADQDQRINTGDE 974
            ....|.|..|.       ::.|.|:..||||||:||.|.|..:.:|||||.||||.|.|:.:|||
Human   802 YENRLPDYQEQ-------DIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDE 859

  Fly   975 ILSIDGINVLNSSHHKVVSLVGESALRGQVTMILRR----------------------------- 1010
            ::.:||..|:..||..||.|:.::|.:|.|.:.:||
Human   860 LICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASL 924

  Fly  1011 ---RRTPLLQQ------------------------APVSTQLRRYPYDVIVSRHENEGFGFVIIS 1048
               :|||...|                        ..|||.::  ||||.:.|.|||||||||:|
Human   925 TEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQ--PYDVEIRRGENEGFGFVIVS 987

  Fly  1049 S-SNHYYGST-----------IGKLIPGSPADRCGELKVGDRIVAVNRIEIAGMSHGDVVNLIKE 1101
            | |....|:|           ||::|.||||||||:|||||||:|||...|...||.|:||||||
Human   988 SVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKE 1052

  Fly  1102 SGLHVRLTIGVPLKEGG-------------------PSPGGSSVGVSSNTPLQASPSLLKAQLSH 1147
            :|..|.|.| :|..|..                   ||..|:....::..|.|.|....||..:.
Human  1053 AGNTVTLRI-IPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQAT 1116

  Fly  1148 QQQ 1150
            |:|
Human  1117 QEQ 1119

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Magi	NP_001286661.1	WW	294..323	CDD:278809	20/28 (71%)
		WW	342..372	CDD:238122	21/29 (72%)
		PDZ	443..534	CDD:214570	52/90 (58%)
		DegQ	<455..534	CDD:223343	45/78 (58%)
		PDZ_signaling	606..668	CDD:238492	33/63 (52%)
		PDZ	925..1011	CDD:214570	39/117 (33%)
		PDZ_signaling	1029..1110	CDD:238492	53/92 (58%)
MAGI1	NP_001028229.1	PDZ_signaling	15..100	CDD:238492
		GuKc	122..293	CDD:214504	30/167 (18%)
		WW	303..332	CDD:238122	20/28 (71%)
		WW	361..390	CDD:278809	20/28 (71%)
		PDZ	469..555	CDD:214570	52/90 (58%)
		PDZ	640..723	CDD:214570	38/111 (34%)
		MAGI_u5	722..805	CDD:293271	24/205 (12%)
		PDZ_signaling	819..894	CDD:238492	35/74 (47%)
		PDZ_signaling	968..1062	CDD:238492	54/94 (57%)
		PDZ	1123..1205	CDD:214570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I7680
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	517	1.000	Inparanoid score	I1288
Isobase	1	0.950	-	1	Normalized mean entropy	S5241
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148234at33208
OrthoFinder	1	1.000	-	-		FOG0000831
OrthoInspector	1	1.000	-	-		otm40810
orthoMCL	1	0.900	-	-		OOG6_102187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X573
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.680