DRSC/TRiP Functional Genomics Resources

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Protein Alignment Magi and HERC3

DIOPT Version :9

Sequence 1:NP_001286661.1 Gene:Magi / 37403 FlyBaseID:FBgn0034590 Length:1202 Species:Drosophila melanogaster
Sequence 2:NP_055421.1 Gene:HERC3 / 8916 HGNCID:4876 Length:1050 Species:Homo sapiens


Alignment Length:731 Identity:131/731 - (17%)
Similarity:218/731 - (29%) Gaps:253/731 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   271 CGVGDVQHQNHESHDDPGDGLGPLPPK----------WETAYTERGELYF----IDHNTGTSHWL 321
            ||:.......||...:..:.:|.|..:          ...|.::||:|:.    .|...|.....
Human    58 CGLNTKGQLGHEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTE 122

  Fly   322 D----PRLSK--YQKKSLEDCCEDELPYGWEKIEDSMYGMYFIDHVNRRTQY----ENPVLEAKR 376
            |    |||.:  .|:..|:..|.:     |..:..:..|.:|....|...|.    |.|      
Human   123 DSVAVPRLIQKLNQQTILQVSCGN-----WHCLALAADGQFFTWGKNSHGQLGLGKEFP------ 176

  Fly   377 RAAEQSQQQQQMQQQQQQMQEQRSKTPTALSETMPTEAAEAH----------------------- 418
                          .|...|..||.....|::   ..|..||                       
Human   177 --------------SQASPQRVRSLEGIPLAQ---VAAGGAHSFALSLSGAVFGWGMNNAGQLGL 224

  Fly   419 -EQEEDESPMKLPYKFTRNPAELQGQRINTTLLKSSRGLGFTI-VGSDGSAGGDV---------- 471
             ::::.|||..:....|:....:.....:|.:|..|.|: ||. .||.|..|.|.          
Human   225 SDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGV-FTFGAGSCGQLGHDSMNDEVNPRRV 288

  Fly   472 -----EEFLQIK-------TVVPNG------PAWLDGQLQTGDVLVYVNDTC---VLGY--THHD 513
                 .|..||.       ..||:.      .....|||.||..   .|..|   |.||  .|..
Human   289 LELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHT---CNVKCPSPVKGYWAAHSG 350

  Fly   514 MV---------NIFQSILPGERAALEVC---RGYPLPFDPNDPNTEVVTTMAVDGRESDKQRRLN 566
            .:         :|.:.|..|......:|   ..|....|....|....|::..|...:..:::|:
Human   351 QLSARADRFKYHIVKQIFSGGDQTFVLCSKYENYSPAVDFRTMNQAHYTSLINDETIAVWRQKLS 415

  Fly   567 MDGNYNFLDLSGEGAKKTSGSGSGFILMKKPEIYTFSIMKGSMGFGFTIADSAC--GQIVKKILD 629
            ...|.|.::                                  |....::.:||  |..::|.:|
Human   416 EHNNANTIN----------------------------------GVVQILSSAACWNGSFLEKKID 446

  Fly   630 RNCCT-------QLMEGDVLLEINGLNVRNKPHFYVVE---------LLKECSQTTP--TAVKIQ 676
            .:..|       .|....||.|    .:.|..|..::|         |:.:.|.:.|  .|::|.
Human   447 EHFKTSPKIPGIDLNSTRVLFE----KLMNSQHSMILEQILNSFESCLIPQLSSSPPDVEAMRIY 507

  Fly   677 RTPPDPPANN------------TLAQLNQVGNVAKLRKN----------------FVGSGLF--- 710
            ...|:.|...            .:|.|....|.:|:..|                :.|:.|:   
Human   508 LILPEFPLLQDSKYYITLTIPLAMAILRLDTNPSKVLDNWWSQVCPKYFMKLVNLYKGAVLYLLR 572

  Fly   711 -RSKTPTADLYSTQVKEVLPMRPKTPLVDTRRSRVQ-----IQSPNNEVDDEGD------GAAAA 763
             |.......|::..:...|.:..|...|:.:...|:     |...:|.||.:.|      ..|..
Human   573 GRKTFLIPVLFNNYITAALKLLEKLYKVNLKVKHVEYDTFYIPEISNLVDIQEDYLMWFLHQAGM 637

  Fly   764 ERKPLQLQTQGKSNSSLQELDDIPYMDPYPKI------SRLSERLAEVTLQGDANGG-------I 815
            :.:|..:|             |...:..||.|      :::.:..||:.:|...||.       :
Human   638 KARPSIIQ-------------DTVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGANLQNVFML 689

  Fly   816 YGMPPSMQPLPLPLAH 831
            ..:.|.:...|..:.|
Human   690 LTLEPLLARSPFLVLH 705

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MagiNP_001286661.1 WW 294..323 CDD:278809 8/46 (17%)
WW 342..372 CDD:238122 7/33 (21%)
PDZ 443..534 CDD:214570 31/136 (23%)
DegQ <455..534 CDD:223343 28/124 (23%)
PDZ_signaling 606..668 CDD:238492 16/79 (20%)
PDZ 925..1011 CDD:214570
PDZ_signaling 1029..1110 CDD:238492
HERC3NP_055421.1 RCC1 1 1..51
ATS1 2..331 CDD:227511 58/301 (19%)
RCC1 2 52..101 7/42 (17%)
RCC1 3 102..154 13/56 (23%)
RCC1 4 156..207 14/73 (19%)
RCC1 5 208..259 6/50 (12%)
RCC1 6 261..311 11/50 (22%)
RCC1 313..377 CDD:366085 14/66 (21%)
RCC1 7 313..366 12/55 (22%)
HECTc 702..1048 CDD:238033 1/4 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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